Severe hemolysis, elevated liver enzymes, and low platelet syndrome requiring differentiation of thrombotic microangiopathy: Four cases from a nationwide survey in Japan

Komatsu, Reina; Mimura, Kazuya; Matsuyama, Tatsuya; Kawanishi, Yoko; Nakamura, Hitomi; Tomimatsu, Takuji; Endo, Masayuki; Kimura, Tadashi

doi:https://doi.org/10.1111/jog.15949

Severe hemolysis, elevated liver enzymes, and low platelet syndrome requiring differentiation of thrombotic microangiopathy: Four cases from a nationwide survey in Japan

Komatsu, Reina; Mimura, Kazuya; Matsuyama, Tatsuya et al.

Journal of Obstetrics and Gynaecology Research, 2024, 50(7), 1258-1262

アクセス数:36件（2025-04-03 19:20 集計）

固定URL: https://hdl.handle.net/11094/97138

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タイトル	Severe hemolysis, elevated liver enzymes, and low platelet syndrome requiring differentiation of thrombotic microangiopathy: Four cases from a nationwide survey in Japan
著者	著者名 Komatsu, Reina
	NRID 1000050437422 1000050437422 researchmap permalink fm1906 fm1906 Scopus Author ID 17435267000 17435267000 著者名 Mimura, Kazuya
	著者名 Matsuyama, Tatsuya
	NRID 1000070876367 1000070876367 researchmap permalink assembly assembly Scopus Author ID 57205751220 57205751220 著者名 Kawanishi, Yoko
	NRID 1000080467571 1000080467571 researchmap permalink hitominakamura hitominakamura Scopus Author ID 35750272100 35750272100 著者名 Nakamura, Hitomi
	NRID 1000030346209 1000030346209 researchmap permalink 2019-10-31 2019-10-31 著者名 Tomimatsu, Takuji
	NRID 1000030644794 1000030644794 researchmap permalink CHOP CHOP Scopus Author ID 35182871900 35182871900 著者名 Endo, Masayuki
	NRID 1000090240845 1000090240845 researchmap permalink read0106368 read0106368 Scopus Author ID 35421281200 35421281200 著者名 Kimura, Tadashi
キーワード等	atypical hemolytic uremic syndrome
	HELLP syndrome
	pre-eclampsia
	pregnancy
	thrombotic microangiopathy
内容	Komatsu R., Mimura K., Matsuyama T., et al. Severe hemolysis, elevated liver enzymes, and low platelet syndrome requiring differentiation of thrombotic microangiopathy: Four cases from a nationwide survey in Japan. Journal of Obstetrics and Gynaecology Research , (2024); https://doi.org/10.1111/jog.15949.
抄録	Severe cases of hemolysis, elevated liver enzymes, and low platelet (HELLP) syndrome requiring plasma exchange or dialysis should be differentiated from other thrombotic microangiopathy (TMA) and treated appropriately. To evaluate the prevalence and clinical characteristics of such cases in Japan, a questionnaire-based survey was conducted among obstetricians who are members of the Perinatal Research Network Group in Japan. There were a total of 335 cases of HELLP syndrome over a 3-year period in the 48 facilities that responded to the survey. Four patients required plasma exchange or dialysis, of which two were diagnosed with atypical hemolytic uremic syndrome and two with TMA secondary to systemic lupus erythematosus. Although such severe HELLP syndrome is rare, identifying the clinical features and making accurate differential diagnosis are critical for optimal clinical outcomes for mothers and neonates.
出版者	John Wiley and Sons Inc
収録物名	Journal of Obstetrics and Gynaecology Research
巻(号)	50(7)
ページ	1258-1262
刊行年月	2024-04-08
言語	英語
ハンドルURL	https://hdl.handle.net/11094/97138
PISSN	13418076
eISSN	14470756
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1111/jog.15949
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCTERMS.bibliographicCitation	Journal of Obstetrics and Gynaecology Research. 2024, 50(7), p. 1258-1262
DC.title	Severe hemolysis, elevated liver enzymes, and low platelet syndrome requiring differentiation of thrombotic microangiopathy: Four cases from a nationwide survey in Japan
DC.creator	Komatsu, Reina
	Mimura, Kazuya
	Matsuyama, Tatsuya
	Kawanishi, Yoko
	Nakamura, Hitomi
	Tomimatsu, Takuji
	Endo, Masayuki
	Kimura, Tadashi
DC.publisher	John Wiley and Sons Inc
DC.language' scheme='DCTERMS.RFC1766	英語
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-04-08
DC.identifier	https://doi.org/10.1111/jog.15949
DC.subject	atypical hemolytic uremic syndrome
	HELLP syndrome
	pre-eclampsia
	pregnancy
	thrombotic microangiopathy
DC.description	Komatsu R., Mimura K., Matsuyama T., et al. Severe hemolysis, elevated liver enzymes, and low platelet syndrome requiring differentiation of thrombotic microangiopathy: Four cases from a nationwide survey in Japan. Journal of Obstetrics and Gynaecology Research , (2024); https://doi.org/10.1111/jog.15949.
DCTERMS.abstract	Severe cases of hemolysis, elevated liver enzymes, and low platelet (HELLP) syndrome requiring plasma exchange or dialysis should be differentiated from other thrombotic microangiopathy (TMA) and treated appropriately. To evaluate the prevalence and clinical characteristics of such cases in Japan, a questionnaire-based survey was conducted among obstetricians who are members of the Perinatal Research Network Group in Japan. There were a total of 335 cases of HELLP syndrome over a 3-year period in the 48 facilities that responded to the survey. Four patients required plasma exchange or dialysis, of which two were diagnosed with atypical hemolytic uremic syndrome and two with TMA secondary to systemic lupus erythematosus. Although such severe HELLP syndrome is rare, identifying the clinical features and making accurate differential diagnosis are critical for optimal clinical outcomes for mothers and neonates.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
DC.format	97138
citation_title	Severe hemolysis, elevated liver enzymes, and low platelet syndrome requiring differentiation of thrombotic microangiopathy: Four cases from a nationwide survey in Japan
citation_author	Komatsu, Reina
	Mimura, Kazuya
	Matsuyama, Tatsuya
	Kawanishi, Yoko
	Nakamura, Hitomi
	Tomimatsu, Takuji
	Endo, Masayuki
	Kimura, Tadashi
citation_publisher	John Wiley and Sons Inc
citation_language	英語
citation_date	2024-04-08
citation_journal_title	Journal of Obstetrics and Gynaecology Research
citation_volume	50
citation_issue	7
citation_firstpage	1258
citation_lastpage	1262
citation_doi	https://doi.org/10.1111/jog.15949
citation_public_url	https://hdl.handle.net/11094/97138

Severe hemolysis, elevated liver enzymes, and low platelet syndrome requiring differentiation of thrombotic microangiopathy: Four cases from a nationwide survey in Japan

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