Disturbance in the protein landscape of cochlear perilymph in an Alzheimer’s disease mouse model

Fukuda, Masatoshi; Okanishi, Hiroki; Ino, Daisuke; Ono, Kazuya; Kawamura, Satoru; Wakai, Eri; Miyoshi, Tsuyoshi; Sato, Takashi; Ohta, Yumi; Saito, Takashi; Saido, Takaomi C.; Inohara, Hidenori; Kanai, Yoshikatsu; Hibino, Hiroshi

doi:https://doi.org/10.1371/journal.pone.0303375

Disturbance in the protein landscape of cochlear perilymph in an Alzheimer’s disease mouse model

Fukuda, Masatoshi; Okanishi, Hiroki; Ino, Daisuke et al.

PLoS ONE, 2024, 19(5), e0303375

アクセス数:1,439件（2025-07-02 15:46 集計）

固定URL: https://hdl.handle.net/11094/97216

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タイトル	Disturbance in the protein landscape of cochlear perilymph in an Alzheimer’s disease mouse model
著者	NRID 1000060909638 1000060909638 著者名 Fukuda, Masatoshi
	NRID 1000070792589 1000070792589 researchmap permalink 7000021427 7000021427 Scopus Author ID 56593651700 56593651700 著者名 Okanishi, Hiroki
	NRID 1000040721981 1000040721981 ORCID 0000-0002-8112-0746 0000-0002-8112-0746 researchmap permalink daisukeino daisukeino 著者名 Ino, Daisuke
	NRID 1000070972165 1000070972165 ORCID 0000-0002-3857-0055 0000-0002-3857-0055 researchmap permalink drono drono 著者名 Ono, Kazuya
	著者名 Kawamura, Satoru
	NRID 1000040964896 1000040964896 researchmap permalink eri_wakai eri_wakai 著者名 Wakai, Eri
	著者名 Miyoshi, Tsuyoshi
	NRID 1000030756002 1000030756002 researchmap permalink 4501 4501 Scopus Author ID 7406982585 7406982585 著者名 Sato, Takashi
	NRID 1000000598401 1000000598401 researchmap permalink osaka-ent osaka-ent Scopus Author ID 54416193500 54416193500 著者名 Ohta, Yumi
	NRID 1000090360552 1000090360552 著者名 Saito, Takashi
	NRID 1000080205690 1000080205690 著者名 Saido, Takaomi C.
	NRID 1000000273657 1000000273657 researchmap permalink read0046473 read0046473 Scopus Author ID 7004501837 7004501837 著者名 Inohara, Hidenori
	NRID 1000060204533 1000060204533 researchmap permalink read0063550 read0063550 Scopus Author ID 55575124400 55575124400 著者名 Kanai, Yoshikatsu
	NRID 1000070314317 1000070314317 researchmap permalink hiroshi_hibino hiroshi_hibino Scopus Author ID 7007020846 7007020846 著者名 Hibino, Hiroshi
内容	Fukuda M., Okanishi H., Ino D., et al. (2024) Disturbance in the protein landscape of cochlear perilymph in an Alzheimer’s disease mouse model. PLoS ONE 19, e0303375. https://doi.org/10.1371/journal.pone.0303375.
抄録	Hearing loss is a pivotal risk factor for dementia. It has recently emerged that a disruption in the intercommunication between the cochlea and brain is a key process in the initiation and progression of this disease. However, whether the cochlear properties can be influenced by pathological signals associated with dementia remains unclear. In this study, using a mouse model of Alzheimer’s disease (AD), we investigated the impacts of the AD-like amyloid β (Aβ) pathology in the brain on the cochlea. Despite little detectable change in the age-related shift of the hearing threshold, we observed quantitative and qualitative alterations in the protein profile in perilymph, an extracellular fluid that fills the path of sound waves in the cochlea. Our findings highlight the potential contribution of Aβ pathology in the brain to the disturbance of cochlear homeostasis.
出版者	Public Library of Science
収録物名	PLoS ONE
巻(号)	19(5)
ページ	e0303375
刊行年月	2024-05-10
言語	英語
ハンドルURL	https://hdl.handle.net/11094/97216
eISSN	19326203
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1371/journal.pone.0303375
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCTERMS.bibliographicCitation	PLoS ONE. 2024, 19(5), p. e0303375
DC.title	Disturbance in the protein landscape of cochlear perilymph in an Alzheimer’s disease mouse model
DC.creator	Fukuda, Masatoshi
	Okanishi, Hiroki
	Ino, Daisuke
	Ono, Kazuya
	Kawamura, Satoru
	Wakai, Eri
	Miyoshi, Tsuyoshi
	Sato, Takashi
	Ohta, Yumi
	Saito, Takashi
	Saido, Takaomi C.
	Inohara, Hidenori
	Kanai, Yoshikatsu
	Hibino, Hiroshi
DC.publisher	Public Library of Science
DC.language' scheme='DCTERMS.RFC1766	英語
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-05-10
DC.identifier	https://doi.org/10.1371/journal.pone.0303375
DC.description	Fukuda M., Okanishi H., Ino D., et al. (2024) Disturbance in the protein landscape of cochlear perilymph in an Alzheimer’s disease mouse model. PLoS ONE 19, e0303375. https://doi.org/10.1371/journal.pone.0303375.
DCTERMS.abstract	Hearing loss is a pivotal risk factor for dementia. It has recently emerged that a disruption in the intercommunication between the cochlea and brain is a key process in the initiation and progression of this disease. However, whether the cochlear properties can be influenced by pathological signals associated with dementia remains unclear. In this study, using a mouse model of Alzheimer’s disease (AD), we investigated the impacts of the AD-like amyloid β (Aβ) pathology in the brain on the cochlea. Despite little detectable change in the age-related shift of the hearing threshold, we observed quantitative and qualitative alterations in the protein profile in perilymph, an extracellular fluid that fills the path of sound waves in the cochlea. Our findings highlight the potential contribution of Aβ pathology in the brain to the disturbance of cochlear homeostasis.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	97216
citation_title	Disturbance in the protein landscape of cochlear perilymph in an Alzheimer’s disease mouse model
citation_author	Fukuda, Masatoshi
	Okanishi, Hiroki
	Ino, Daisuke
	Ono, Kazuya
	Kawamura, Satoru
	Wakai, Eri
	Miyoshi, Tsuyoshi
	Sato, Takashi
	Ohta, Yumi
	Saito, Takashi
	Saido, Takaomi C.
	Inohara, Hidenori
	Kanai, Yoshikatsu
	Hibino, Hiroshi
citation_publisher	Public Library of Science
citation_language	英語
citation_date	2024-05-10
citation_journal_title	PLoS ONE
citation_volume	19
citation_issue	5
citation_firstpage	e0303375
citation_doi	https://doi.org/10.1371/journal.pone.0303375
citation_public_url	https://hdl.handle.net/11094/97216

Disturbance in the protein landscape of cochlear perilymph in an Alzheimer’s disease mouse model

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