Repetitive transcranial magnetic stimulation focusing on patients with neuropathic pain in the upper limb: a randomized sham-controlled parallel trial

Mori, Nobuhiko; Hosomi, Koichi; Nishi, Asaya; Miyake, Akimitsu; Yamada, Tomomi; Matsugi, Akiyoshi; Jono, Yasutomo; Lim, Chanseok; Khoo, Hui Ming; Tani, Naoki; Oshino, Satoru; Saitoh, Youichi; Kishima, Haruhiko

doi:https://doi.org/10.1038/s41598-024-62018-x

Repetitive transcranial magnetic stimulation focusing on patients with neuropathic pain in the upper limb: a randomized sham-controlled parallel trial

Mori, Nobuhiko; Hosomi, Koichi; Nishi, Asaya et al.

Scientific Reports, 2024, 14, 11811

アクセス数:1,559件（2025-07-15 05:48 集計）

固定URL: https://hdl.handle.net/11094/97225

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タイトル	Repetitive transcranial magnetic stimulation focusing on patients with neuropathic pain in the upper limb: a randomized sham-controlled parallel trial
著者	NRID 1000020833924 1000020833924 ORCID 0000-0001-6537-6322 0000-0001-6537-6322 researchmap permalink Mori_Nobuhiko Mori_Nobuhiko 著者名 Mori, Nobuhiko
	NRID 1000070533800 1000070533800 researchmap permalink HosomiKoichi HosomiKoichi Scopus Author ID 23967898900 23967898900 ORCID 0000-0001-7731-3302 0000-0001-7731-3302 著者名 Hosomi, Koichi
	著者名 Nishi, Asaya
	NRID 1000070872290 1000070872290 著者名 Miyake, Akimitsu
	NRID 1000060363371 1000060363371 researchmap permalink ymd ymd Scopus Author ID 35254679600 35254679600 著者名 Yamada, Tomomi
	NRID 1000020624026 1000020624026 著者名 Matsugi, Akiyoshi
	著者名 Jono, Yasutomo
	著者名 Lim, Chanseok
	NRID 1000070591022 1000070591022 ORCID 0000-0002-4039-0520 0000-0002-4039-0520 researchmap permalink hmkhoo hmkhoo Scopus Author ID 55314143200 55314143200 著者名 Khoo, Hui Ming
	NRID 1000020598370 1000020598370 researchmap permalink n_taniOsakaUniv n_taniOsakaUniv Scopus Author ID 7103335692 7103335692 著者名 Tani, Naoki
	NRID 1000040403050 1000040403050 ORCID 0000-0002-4248-2322 0000-0002-4248-2322 researchmap permalink handai_ns_oshino handai_ns_oshino Scopus Author ID 6602717325 6602717325 著者名 Oshino, Satoru
	NRID 1000020252661 1000020252661 researchmap permalink read0076638 read0076638 著者名 Saitoh, Youichi
	NRID 1000010332743 1000010332743 researchmap permalink hkishima hkishima Scopus Author ID 6603783358 6603783358 ORCID 0000-0002-9041-2337 0000-0002-9041-2337 著者名 Kishima, Haruhiko
内容	Mori N., Hosomi K., Nishi A., et al. Repetitive transcranial magnetic stimulation focusing on patients with neuropathic pain in the upper limb: a randomized sham-controlled parallel trial. Scientific Reports 14, 11811 (2024); https://doi.org/10.1038/s41598-024-62018-x.
抄録	This study aimed to evaluate the efficacy and safety of navigation-guided repetitive transcranial magnetic stimulation (rTMS) over the primary motor cortex in patients with neuropathic pain in the upper limb. This randomized, blinded, sham-controlled, parallel trial included a rTMS protocol (10-Hz, 2000 pulses/session) consisting of five daily sessions, followed by one session per week for the next seven weeks. Pain intensity, as well as pain-related disability, quality of life, and psychological status, were assessed. For the primary outcome, pain intensity was measured daily using a numerical rating scale as a pain diary. Thirty patients were randomly assigned to the active rTMS or sham-stimulation groups. In the primary outcome, the decrease (least square [LS] mean ± standard error) in the weekly average of a pain diary at week 9 compared to the baseline was 0.84 ± 0.31 in the active rTMS group and 0.58 ± 0.29 in the sham group (LS mean difference, 0.26; 95% confidence interval, − 0.60 to 1.13). There was no significant effect on the interaction between the treatment group and time point. Pain-related disability score improved, but other assessments showed no differences. No serious adverse events were observed. This study did not show significant pain relief; however, active rTMS tended to provide better results than sham. rTMS has the potential to improve pain-related disability in addition to pain relief.
出版者	Nature Research
収録物名	Scientific Reports
巻(号)	14
ページ	11811
刊行年月	2024-05-23
言語	英語
ハンドルURL	https://hdl.handle.net/11094/97225
eISSN	20452322
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1038/s41598-024-62018-x
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCTERMS.bibliographicCitation	Scientific Reports. 2024, 14, p. 11811
DC.title	Repetitive transcranial magnetic stimulation focusing on patients with neuropathic pain in the upper limb: a randomized sham-controlled parallel trial
DC.creator	Mori, Nobuhiko
	Hosomi, Koichi
	Nishi, Asaya
	Miyake, Akimitsu
	Yamada, Tomomi
	Matsugi, Akiyoshi
	Jono, Yasutomo
	Lim, Chanseok
	Khoo, Hui Ming
	Tani, Naoki
	Oshino, Satoru
	Saitoh, Youichi
	Kishima, Haruhiko
DC.publisher	Nature Research
DC.language' scheme='DCTERMS.RFC1766	英語
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-05-23
DC.identifier	https://doi.org/10.1038/s41598-024-62018-x
DC.description	Mori N., Hosomi K., Nishi A., et al. Repetitive transcranial magnetic stimulation focusing on patients with neuropathic pain in the upper limb: a randomized sham-controlled parallel trial. Scientific Reports 14, 11811 (2024); https://doi.org/10.1038/s41598-024-62018-x.
DCTERMS.abstract	This study aimed to evaluate the efficacy and safety of navigation-guided repetitive transcranial magnetic stimulation (rTMS) over the primary motor cortex in patients with neuropathic pain in the upper limb. This randomized, blinded, sham-controlled, parallel trial included a rTMS protocol (10-Hz, 2000 pulses/session) consisting of five daily sessions, followed by one session per week for the next seven weeks. Pain intensity, as well as pain-related disability, quality of life, and psychological status, were assessed. For the primary outcome, pain intensity was measured daily using a numerical rating scale as a pain diary. Thirty patients were randomly assigned to the active rTMS or sham-stimulation groups. In the primary outcome, the decrease (least square [LS] mean ± standard error) in the weekly average of a pain diary at week 9 compared to the baseline was 0.84 ± 0.31 in the active rTMS group and 0.58 ± 0.29 in the sham group (LS mean difference, 0.26; 95% confidence interval, − 0.60 to 1.13). There was no significant effect on the interaction between the treatment group and time point. Pain-related disability score improved, but other assessments showed no differences. No serious adverse events were observed. This study did not show significant pain relief; however, active rTMS tended to provide better results than sham. rTMS has the potential to improve pain-related disability in addition to pain relief.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	97225
citation_title	Repetitive transcranial magnetic stimulation focusing on patients with neuropathic pain in the upper limb: a randomized sham-controlled parallel trial
citation_author	Mori, Nobuhiko
	Hosomi, Koichi
	Nishi, Asaya
	Miyake, Akimitsu
	Yamada, Tomomi
	Matsugi, Akiyoshi
	Jono, Yasutomo
	Lim, Chanseok
	Khoo, Hui Ming
	Tani, Naoki
	Oshino, Satoru
	Saitoh, Youichi
	Kishima, Haruhiko
citation_publisher	Nature Research
citation_language	英語
citation_date	2024-05-23
citation_journal_title	Scientific Reports
citation_volume	14
citation_firstpage	11811
citation_doi	https://doi.org/10.1038/s41598-024-62018-x
citation_public_url	https://hdl.handle.net/11094/97225

Repetitive transcranial magnetic stimulation focusing on patients with neuropathic pain in the upper limb: a randomized sham-controlled parallel trial

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