Sex-dependent regulation of vertebrate somatic growth and aging by germ cells

Abe, Kota; Ino, Hikaru; Niwa, Tomomi et al.

Science Advances, 2024, 10(24), eadi1621

アクセス数:962件（2025-07-11 18:22 集計）

固定URL: https://hdl.handle.net/11094/97227

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タイトル
Sex-dependent regulation of vertebrate somatic growth and aging by germ cells
著者
NRID
1000010867279 1000010867279
researchmap permalink
koa koa
著者名
Abe, Kota
著者名
Ino, Hikaru
著者名
Niwa, Tomomi
著者名
Semmy, Daniel
著者名
Takaochi, Ayami
NRID
1000090568099 1000090568099
著者名
Nishimura, Takashi
NRID
1000000375528 1000000375528
著者名
Mogi, Chihiro
NRID
1000090468265 1000090468265
researchmap permalink
umaki umaki
著者名
Uenaka, Maki
NRID
1000010324758 1000010324758
researchmap permalink
read0076684 read0076684
Scopus Author ID
35074093500 35074093500
著者名
Ishii, Masaru
著者名
Tanaka, Kaori
NRID
1000080448430 1000080448430
著者名
Ohkawa, Yasuyuki
NRID
1000040448428 1000040448428
ORCID
0000-0002-6200-7043 0000-0002-6200-7043
researchmap permalink
read0148831 read0148831
Scopus Author ID
8079317200 8079317200
著者名
Ishitani, Tohru
内容
Abe K., Ino H., Niwa T., et al. Sex-dependent regulation of vertebrate somatic growth and aging by germ cells. Science Advances 10, eadi1621 (2024); https://doi.org/10.1126/sciadv.adi1621.
抄録
The function of germ cells in somatic growth and aging has been demonstrated in invertebrate models but remains unclear in vertebrates. We demonstrated sex-dependent somatic regulation by germ cells in the short-lived vertebrate model Nothobranchius furzeri. In females, germ cell removal shortened life span, decreased estrogen, and increased insulin-like growth factor 1 (IGF-1) signaling. In contrast, germ cell removal in males improved their health with increased vitamin D signaling. Body size increased in both sexes but was caused by different signaling pathways, i.e., IGF-1 and vitamin D in females and males, respectively. Thus, vertebrate germ cells regulate somatic growth and aging through different pathways of the endocrine system, depending on the sex, which may underlie the sexual difference in reproductive strategies.
出版者
American Association for the Advancement of Science
収録物名
Science Advances
巻(号)
10(24)
ページ
eadi1621
刊行年月
2024-06-14
言語
英語
ハンドルURL
https://hdl.handle.net/11094/97227
eISSN
23752548
関連情報 (isIdenticalTo)
DOI (出版社版)
https://doi.org/10.1126/sciadv.adi1621
アクセス権
open access
権利情報
This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ
Version of Record
カテゴリ
学術雑誌論文 Journal Article