Sex-dependent regulation of vertebrate somatic growth and aging by germ cells

Abe, Kota; Ino, Hikaru; Niwa, Tomomi; Semmy, Daniel; Takaochi, Ayami; Nishimura, Takashi; Mogi, Chihiro; Uenaka, Maki; Ishii, Masaru; Tanaka, Kaori; Ohkawa, Yasuyuki; Ishitani, Tohru

doi:https://doi.org/10.1126/sciadv.adi1621

Sex-dependent regulation of vertebrate somatic growth and aging by germ cells

Abe, Kota; Ino, Hikaru; Niwa, Tomomi et al.

Science Advances, 2024, 10(24), eadi1621

アクセス数:960件（2025-07-11 16:45 集計）

固定URL: https://hdl.handle.net/11094/97227

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タイトル	Sex-dependent regulation of vertebrate somatic growth and aging by germ cells
著者	NRID 1000010867279 1000010867279 researchmap permalink koa koa 著者名 Abe, Kota
	著者名 Ino, Hikaru
	著者名 Niwa, Tomomi
	著者名 Semmy, Daniel
	著者名 Takaochi, Ayami
	NRID 1000090568099 1000090568099 著者名 Nishimura, Takashi
	NRID 1000000375528 1000000375528 著者名 Mogi, Chihiro
	NRID 1000090468265 1000090468265 researchmap permalink umaki umaki 著者名 Uenaka, Maki
	NRID 1000010324758 1000010324758 researchmap permalink read0076684 read0076684 Scopus Author ID 35074093500 35074093500 著者名 Ishii, Masaru
	著者名 Tanaka, Kaori
	NRID 1000080448430 1000080448430 著者名 Ohkawa, Yasuyuki
	NRID 1000040448428 1000040448428 ORCID 0000-0002-6200-7043 0000-0002-6200-7043 researchmap permalink read0148831 read0148831 Scopus Author ID 8079317200 8079317200 著者名 Ishitani, Tohru
内容	Abe K., Ino H., Niwa T., et al. Sex-dependent regulation of vertebrate somatic growth and aging by germ cells. Science Advances 10, eadi1621 (2024); https://doi.org/10.1126/sciadv.adi1621.
抄録	The function of germ cells in somatic growth and aging has been demonstrated in invertebrate models but remains unclear in vertebrates. We demonstrated sex-dependent somatic regulation by germ cells in the short-lived vertebrate model Nothobranchius furzeri. In females, germ cell removal shortened life span, decreased estrogen, and increased insulin-like growth factor 1 (IGF-1) signaling. In contrast, germ cell removal in males improved their health with increased vitamin D signaling. Body size increased in both sexes but was caused by different signaling pathways, i.e., IGF-1 and vitamin D in females and males, respectively. Thus, vertebrate germ cells regulate somatic growth and aging through different pathways of the endocrine system, depending on the sex, which may underlie the sexual difference in reproductive strategies.
出版者	American Association for the Advancement of Science
収録物名	Science Advances
巻(号)	10(24)
ページ	eadi1621
刊行年月	2024-06-14
言語	英語
ハンドルURL	https://hdl.handle.net/11094/97227
eISSN	23752548
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1126/sciadv.adi1621
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCTERMS.bibliographicCitation	Science Advances. 2024, 10(24), p. eadi1621
DC.title	Sex-dependent regulation of vertebrate somatic growth and aging by germ cells
DC.creator	Abe, Kota
	Ino, Hikaru
	Niwa, Tomomi
	Semmy, Daniel
	Takaochi, Ayami
	Nishimura, Takashi
	Mogi, Chihiro
	Uenaka, Maki
	Ishii, Masaru
	Tanaka, Kaori
	Ohkawa, Yasuyuki
	Ishitani, Tohru
DC.publisher	American Association for the Advancement of Science
DC.language' scheme='DCTERMS.RFC1766	英語
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-06-14
DC.identifier	https://doi.org/10.1126/sciadv.adi1621
DC.description	Abe K., Ino H., Niwa T., et al. Sex-dependent regulation of vertebrate somatic growth and aging by germ cells. Science Advances 10, eadi1621 (2024); https://doi.org/10.1126/sciadv.adi1621.
DCTERMS.abstract	The function of germ cells in somatic growth and aging has been demonstrated in invertebrate models but remains unclear in vertebrates. We demonstrated sex-dependent somatic regulation by germ cells in the short-lived vertebrate model Nothobranchius furzeri. In females, germ cell removal shortened life span, decreased estrogen, and increased insulin-like growth factor 1 (IGF-1) signaling. In contrast, germ cell removal in males improved their health with increased vitamin D signaling. Body size increased in both sexes but was caused by different signaling pathways, i.e., IGF-1 and vitamin D in females and males, respectively. Thus, vertebrate germ cells regulate somatic growth and aging through different pathways of the endocrine system, depending on the sex, which may underlie the sexual difference in reproductive strategies.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	97227
citation_title	Sex-dependent regulation of vertebrate somatic growth and aging by germ cells
citation_author	Abe, Kota
	Ino, Hikaru
	Niwa, Tomomi
	Semmy, Daniel
	Takaochi, Ayami
	Nishimura, Takashi
	Mogi, Chihiro
	Uenaka, Maki
	Ishii, Masaru
	Tanaka, Kaori
	Ohkawa, Yasuyuki
	Ishitani, Tohru
citation_publisher	American Association for the Advancement of Science
citation_language	英語
citation_date	2024-06-14
citation_journal_title	Science Advances
citation_volume	10
citation_issue	24
citation_firstpage	eadi1621
citation_doi	https://doi.org/10.1126/sciadv.adi1621
citation_public_url	https://hdl.handle.net/11094/97227

Sex-dependent regulation of vertebrate somatic growth and aging by germ cells

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