Development of elliptic core-shell nanoparticles with fluorinated surfactants for ¹⁹F MRI

Wu, Yue; Minoshima, Masafumi; Kikuchi, Kazuya

Frontiers in Chemistry, 2024, 12, 1408509

アクセス数:65件（2025-05-15 02:25 集計）

固定URL: https://hdl.handle.net/11094/97262

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タイトル
Development of elliptic core-shell nanoparticles with fluorinated surfactants for ¹⁹F MRI
著者
著者名
Wu, Yue
NRID
1000020600844 1000020600844
ORCID
0000-0002-9352-3454 0000-0002-9352-3454
researchmap permalink
cbatgcm_m33 cbatgcm_m33
Scopus Author ID
12774750700 12774750700
著者名
Minoshima, Masafumi
NRID
1000070292951 1000070292951
researchmap permalink
kikuchilab315 kikuchilab315
Scopus Author ID
7404088901 7404088901
著者名
Kikuchi, Kazuya
キーワード等
19F MRI
core-shell nanoparticles
fluorinated surfactant
nanoparticles
silica nanoparticles
内容
Wu Y., Minoshima M., Kikuchi K.. Development of elliptic core-shell nanoparticles with fluorinated surfactants for ¹⁹F MRI. Frontiers in Chemistry 12, 1408509 (2024); https://doi.org/10.3389/fchem.2024.1408509.
抄録
Perfluorocarbon-encapsulated silica nanoparticles possess attractive features such as biological inertness and favorable colloidal properties for bioimaging with fluorine magnetic resonance imaging (¹⁹F MRI). Herein, a series of elliptic shaped silica nanoparticles with perfluorocarbon liquid perfluoro-15-crown-5 ether as core (PFCE@SiO₂) were synthesized using fluorinated surfactants N-(perfluorononylmethyl)-N,N,N-trimethylammonium chloride (C10-TAC) and N-(perfluoroheptylmethyl)-N,N,N-trimethylammonium chloride (C8-TAC). The nanoparticles are characterized to obtain elliptic core-shell structures. PFCE@SiO₂ showed strong ¹⁹F NMR signals of the encapsulated PFCE, indicating the potential as a highly sensitive ¹⁹F MRI probe. These elliptic PFCE@SiO₂ nanoparticles provide a new option of ¹⁹F MRI probe with a morphology different from conventional nanospheres.
出版者
Frontiers Media SA
収録物名
Frontiers in Chemistry
巻(号)
12
ページ
1408509
刊行年月
2024-06-12
言語
英語
ハンドルURL
https://hdl.handle.net/11094/97262
eISSN
22962646
関連情報 (isIdenticalTo)
DOI (出版社版)
https://doi.org/10.3389/fchem.2024.1408509
アクセス権
open access
権利情報
This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ
Version of Record
カテゴリ
学術雑誌論文 Journal Article