Impact of human papillomavirus types on uterine cervical neoplasia

Taguchi, Ayumi; Yoshimoto, Daisuke; Kusakabe, Misako; Baba, Satoshi; Kawata, Akira; Miyamoto, Yuichiro; Mori, Mayuyo; Sone, Kenbun; Hirota, Yasushi; Osuga, Yutaka

doi:https://doi.org/10.1111/jog.15995

Impact of human papillomavirus types on uterine cervical neoplasia

Taguchi, Ayumi; Yoshimoto, Daisuke; Kusakabe, Misako et al.

Journal of Obstetrics and Gynaecology Research, 2024

アクセス数:26件（2025-03-19 14:45 集計）

固定URL: https://hdl.handle.net/11094/97610

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タイトル	Impact of human papillomavirus types on uterine cervical neoplasia
著者	NRID 1000060756782 1000060756782 ORCID 0000-0002-5491-3871 0000-0002-5491-3871 researchmap permalink at246 at246 著者名 Taguchi, Ayumi
	著者名 Yoshimoto, Daisuke
	NRID 1000020990253 1000020990253 著者名 Kusakabe, Misako
	著者名 Baba, Satoshi
	NRID 1000090897290 1000090897290 著者名 Kawata, Akira
	NRID 1000070634955 1000070634955 著者名 Miyamoto, Yuichiro
	NRID 1000030570452 1000030570452 著者名 Mori, Mayuyo
	NRID 1000090598872 1000090598872 著者名 Sone, Kenbun
	NRID 1000040598653 1000040598653 著者名 Hirota, Yasushi
	NRID 1000080260496 1000080260496 著者名 Osuga, Yutaka
キーワード等	cervical cancer
	cervical intraepithelial neoplasia
	genotype
	human papillomavirus
	stem cell
内容	Taguchi A., Yoshimoto D., Kusakabe M., et al. Impact of human papillomavirus types on uterine cervical neoplasia. Journal of Obstetrics and Gynaecology Research, (2024); https://doi.org/10.1111/jog.15995.
抄録	Human papillomavirus (HPV) is a major cause of cervical cancer. As the natural history of HPV-associated cervical lesions is HPV genotype-dependent, it is important to understand the characteristics of these genotypes and to manage them accordingly. Among high-risk HPVs, HPV16 and 18 are particularly aggressive, together accounting for 70% of HPV genotypes detected in cervical cancer. Other than HPV16 and 18, HPV31, 33, 35, 45, 52, and 58 are also at a high risk of progression to cervical intraepithelial neoplasia (CIN)3 or higher. Recent studies have shown that the natural history of HPV16, 18, 52, and 58, which are frequently detected in Japan, depends on the HPV genotype. For example, HPV16 tends to progress in a stepwise fashion from CIN1 to CIN3, while HPV52 and 58 are more likely to persist in the CIN1 to CIN2 state. Among the high-risk HPVs, HPV18 has some peculiar characteristics different from those of other high-risk HPV types; the detection rate in precancerous lesions is much lower than those of other high-risk HPVs, and it is frequently detected in highly malignant adenocarcinoma and small cell carcinoma. Recent findings demonstrate that HPV18 may be characterized by latent infection and carcinogenesis in stem cell-like cells. In this context, this review outlines the natural history of HPV-infected cervical lesions and the characteristics of each HPV genotype.
出版者	John Wiley and Sons Inc
収録物名	Journal of Obstetrics and Gynaecology Research
刊行年月	2024-06-09
言語	英語
ハンドルURL	https://hdl.handle.net/11094/97610
PISSN	13418076
eISSN	14470756
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1111/jog.15995
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCTERMS.bibliographicCitation	Journal of Obstetrics and Gynaecology Research. 2024
DC.title	Impact of human papillomavirus types on uterine cervical neoplasia
DC.creator	Taguchi, Ayumi
	Yoshimoto, Daisuke
	Kusakabe, Misako
	Baba, Satoshi
	Kawata, Akira
	Miyamoto, Yuichiro
	Mori, Mayuyo
	Sone, Kenbun
	Hirota, Yasushi
	Osuga, Yutaka
DC.publisher	John Wiley and Sons Inc
DC.language' scheme='DCTERMS.RFC1766	英語
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-06-09
DC.identifier	https://doi.org/10.1111/jog.15995
DC.subject	cervical cancer
	cervical intraepithelial neoplasia
	genotype
	human papillomavirus
	stem cell
DC.description	Taguchi A., Yoshimoto D., Kusakabe M., et al. Impact of human papillomavirus types on uterine cervical neoplasia. Journal of Obstetrics and Gynaecology Research, (2024); https://doi.org/10.1111/jog.15995.
DCTERMS.abstract	Human papillomavirus (HPV) is a major cause of cervical cancer. As the natural history of HPV-associated cervical lesions is HPV genotype-dependent, it is important to understand the characteristics of these genotypes and to manage them accordingly. Among high-risk HPVs, HPV16 and 18 are particularly aggressive, together accounting for 70% of HPV genotypes detected in cervical cancer. Other than HPV16 and 18, HPV31, 33, 35, 45, 52, and 58 are also at a high risk of progression to cervical intraepithelial neoplasia (CIN)3 or higher. Recent studies have shown that the natural history of HPV16, 18, 52, and 58, which are frequently detected in Japan, depends on the HPV genotype. For example, HPV16 tends to progress in a stepwise fashion from CIN1 to CIN3, while HPV52 and 58 are more likely to persist in the CIN1 to CIN2 state. Among the high-risk HPVs, HPV18 has some peculiar characteristics different from those of other high-risk HPV types; the detection rate in precancerous lesions is much lower than those of other high-risk HPVs, and it is frequently detected in highly malignant adenocarcinoma and small cell carcinoma. Recent findings demonstrate that HPV18 may be characterized by latent infection and carcinogenesis in stem cell-like cells. In this context, this review outlines the natural history of HPV-infected cervical lesions and the characteristics of each HPV genotype.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
DC.format	97610
citation_title	Impact of human papillomavirus types on uterine cervical neoplasia
citation_author	Taguchi, Ayumi
	Yoshimoto, Daisuke
	Kusakabe, Misako
	Baba, Satoshi
	Kawata, Akira
	Miyamoto, Yuichiro
	Mori, Mayuyo
	Sone, Kenbun
	Hirota, Yasushi
	Osuga, Yutaka
citation_publisher	John Wiley and Sons Inc
citation_language	英語
citation_date	2024-06-09
citation_journal_title	Journal of Obstetrics and Gynaecology Research
citation_doi	https://doi.org/10.1111/jog.15995
citation_public_url	https://hdl.handle.net/11094/97610

Impact of human papillomavirus types on uterine cervical neoplasia

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