Clinical significance of ribosomal protein S15 expression in patients with colorectal cancer liver metastases

Sakano, Yoshihiro; Matoba, Daijiro; Noda, Takehiro; Kobayashi, Shogo; Yamada, Daisaku; Tomimaru, Yoshito; Takahashi, Hidenori; Uemura, Mamoru; Doki, Yuichiro; Eguchi, Hidetoshi

doi:https://doi.org/10.1002/jhbp.12012

Clinical significance of ribosomal protein S15 expression in patients with colorectal cancer liver metastases

Sakano, Yoshihiro; Matoba, Daijiro; Noda, Takehiro et al.

Journal of Hepato-Biliary-Pancreatic Sciences, 2024

アクセス数:75件（2025-04-18 20:51 集計）

固定URL: https://hdl.handle.net/11094/97613

閲覧可能ファイル

ファイル	フォーマット	利用条件	サイズ	閲覧回数	利用開始日	説明	information
JHepato-Biliary-PancreaticSci_jhbp.12012	pdf	なし	23.7 MB	50	2024.08.02

Creative Commons : 表示

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

タイトル	Clinical significance of ribosomal protein S15 expression in patients with colorectal cancer liver metastases
著者	NRID 1000020850267 1000020850267 著者名 Sakano, Yoshihiro
	NRID 1000080966549 1000080966549 著者名 Matoba, Daijiro
	NRID 1000050528594 1000050528594 researchmap permalink t-noda t-noda Scopus Author ID 12764559600 12764559600 ORCID 0000-0002-6768-5783 0000-0002-6768-5783 著者名 Noda, Takehiro
	NRID 1000030452436 1000030452436 researchmap permalink 30452436 30452436 Scopus Author ID 7405376089 7405376089 ORCID 0000-0002-8828-1067 0000-0002-8828-1067 著者名 Kobayashi, Shogo
	NRID 1000060571396 1000060571396 ORCID 0000-0002-6702-3800 0000-0002-6702-3800 researchmap permalink dyamada79222 dyamada79222 Scopus Author ID 37008067700 37008067700 著者名 Yamada, Daisaku
	NRID 1000070528570 1000070528570 researchmap permalink yoshitotomimaru yoshitotomimaru Scopus Author ID 10240341100 10240341100 著者名 Tomimaru, Yoshito
	NRID 1000090601120 1000090601120 ORCID 0000-0003-4801-3540 0000-0003-4801-3540 researchmap permalink hdnr_tkhs hdnr_tkhs Scopus Author ID 7405468781 7405468781 著者名 Takahashi, Hidenori
	NRID 1000010528483 1000010528483 ORCID 0000-0001-6285-5619 0000-0001-6285-5619 researchmap permalink mamoruuemura mamoruuemura Scopus Author ID 36796497400 36796497400 著者名 Uemura, Mamoru
	NRID 1000020291445 1000020291445 researchmap permalink ydoki3251 ydoki3251 Scopus Author ID 7006390687 7006390687 著者名 Doki, Yuichiro
	NRID 1000090542118 1000090542118 researchmap permalink abcdabcdabcd abcdabcdabcd Scopus Author ID 7101627772 7101627772 著者名 Eguchi, Hidetoshi
キーワード等	apoptosis
	colorectal cancer
	liver metastasis
	RPS15
内容	Sakano Y., Matoba D., Noda T., et al. Clinical significance of ribosomal protein S15 expression in patients with colorectal cancer liver metastases. Journal of Hepato-Biliary-Pancreatic Sciences, (2024); https://doi.org/10.1002/jhbp.12012.
抄録	Background: Liver metastasis is the most frequently observed distant metastasis of colorectal cancer, and the residual liver recurrence rate after hepatic resection is still high. To explore the mechanism of liver metastasis to discover potential new treatments, we assessed the relationship between the expression of differentially expressed genes (DEGs) and prognosis in patients with colorectal cancer liver metastasis (CRLM). Methods: The gene expression dataset was extracted from The Cancer Genome Atlas and the Gene Expression Omnibus. Significance analysis of DEGs between tumor and normal samples of colorectum, liver, and lung was conducted. A total of 80 CRLM patients were studied to assess the expression of RPS15, characteristics, and outcomes. We examined the relationships of RPS15 expression to cell viability and apoptosis in vitro and vivo. Results: Significance analysis identified 33 DEGs. In our cohorts, the overall survival rates were significantly lower in the high-RPS15-expression group, and high expression of RPS15 was an independent and unfavorable prognostic factor in recurrence-free survival and overall survival. Knockdown of RPS15 expression reduced the proliferative capacity of colorectal cancer cells and increased BAX-induced apoptotic cell death. Conclusions: RPS15 expression is an independent prognostic factor for CRLM patients and might be a novel therapeutic target for CRLM.
出版者	John Wiley and Sons Inc
収録物名	Journal of Hepato-Biliary-Pancreatic Sciences
刊行年月	2024-06-04
言語	英語
ハンドルURL	https://hdl.handle.net/11094/97613
PISSN	18686974
eISSN	18686982
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1002/jhbp.12012
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCTERMS.bibliographicCitation	Journal of Hepato-Biliary-Pancreatic Sciences. 2024
DC.title	Clinical significance of ribosomal protein S15 expression in patients with colorectal cancer liver metastases
DC.creator	Sakano, Yoshihiro
	Matoba, Daijiro
	Noda, Takehiro
	Kobayashi, Shogo
	Yamada, Daisaku
	Tomimaru, Yoshito
	Takahashi, Hidenori
	Uemura, Mamoru
	Doki, Yuichiro
	Eguchi, Hidetoshi
DC.publisher	John Wiley and Sons Inc
DC.language' scheme='DCTERMS.RFC1766	英語
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-06-04
DC.identifier	https://doi.org/10.1002/jhbp.12012
DC.subject	apoptosis
	colorectal cancer
	liver metastasis
	RPS15
DC.description	Sakano Y., Matoba D., Noda T., et al. Clinical significance of ribosomal protein S15 expression in patients with colorectal cancer liver metastases. Journal of Hepato-Biliary-Pancreatic Sciences, (2024); https://doi.org/10.1002/jhbp.12012.
DCTERMS.abstract	Background: Liver metastasis is the most frequently observed distant metastasis of colorectal cancer, and the residual liver recurrence rate after hepatic resection is still high. To explore the mechanism of liver metastasis to discover potential new treatments, we assessed the relationship between the expression of differentially expressed genes (DEGs) and prognosis in patients with colorectal cancer liver metastasis (CRLM). Methods: The gene expression dataset was extracted from The Cancer Genome Atlas and the Gene Expression Omnibus. Significance analysis of DEGs between tumor and normal samples of colorectum, liver, and lung was conducted. A total of 80 CRLM patients were studied to assess the expression of RPS15, characteristics, and outcomes. We examined the relationships of RPS15 expression to cell viability and apoptosis in vitro and vivo. Results: Significance analysis identified 33 DEGs. In our cohorts, the overall survival rates were significantly lower in the high-RPS15-expression group, and high expression of RPS15 was an independent and unfavorable prognostic factor in recurrence-free survival and overall survival. Knockdown of RPS15 expression reduced the proliferative capacity of colorectal cancer cells and increased BAX-induced apoptotic cell death. Conclusions: RPS15 expression is an independent prognostic factor for CRLM patients and might be a novel therapeutic target for CRLM.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	97613
citation_title	Clinical significance of ribosomal protein S15 expression in patients with colorectal cancer liver metastases
citation_author	Sakano, Yoshihiro
	Matoba, Daijiro
	Noda, Takehiro
	Kobayashi, Shogo
	Yamada, Daisaku
	Tomimaru, Yoshito
	Takahashi, Hidenori
	Uemura, Mamoru
	Doki, Yuichiro
	Eguchi, Hidetoshi
citation_publisher	John Wiley and Sons Inc
citation_language	英語
citation_date	2024-06-04
citation_journal_title	Journal of Hepato-Biliary-Pancreatic Sciences
citation_doi	https://doi.org/10.1002/jhbp.12012
citation_public_url	https://hdl.handle.net/11094/97613

Clinical significance of ribosomal protein S15 expression in patients with colorectal cancer liver metastases

閲覧可能ファイル

論文情報

論文詳細を表示