TiO₂ nanotubes with customized diameters for local drug delivery systems

Miyabe, Sayaka; Fujinaga, Yushi; Tsuchiya, Hiroaki; Fujimoto, Shinji

doi:https://doi.org/10.1002/jbm.b.35445

TiO₂ nanotubes with customized diameters for local drug delivery systems

Miyabe, Sayaka; Fujinaga, Yushi; Tsuchiya, Hiroaki et al.

Journal of Biomedical Materials Research - Part B Applied Biomaterials, 2024, 112(7), e35445

アクセス数:602件（2025-07-15 12:01 集計）

固定URL: https://hdl.handle.net/11094/97617

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タイトル	TiO₂ nanotubes with customized diameters for local drug delivery systems
著者	NRID 1000050584132 1000050584132 researchmap permalink read0151100 read0151100 Scopus Author ID 16239274400 16239274400 著者名 Miyabe, Sayaka
	著者名 Fujinaga, Yushi
	NRID 1000050432513 1000050432513 ORCID 0000-0001-5619-0139 0000-0001-5619-0139 researchmap permalink read0076368 read0076368 Scopus Author ID 7202203364 7202203364 著者名 Tsuchiya, Hiroaki
	NRID 1000070199371 1000070199371 ORCID 0000-0002-7787-4190 0000-0002-7787-4190 researchmap permalink read0013980 read0013980 Scopus Author ID 57211614674 57211614674 著者名 Fujimoto, Shinji
キーワード等	anodization
	local drug delivery system
	oxide nanotubes
	TiO₂ nanotubes
内容	Miyabe S., Fujinaga Y., Tsuchiya H., et al. TiO₂ nanotubes with customized diameters for local drug delivery systems. Journal of Biomedical Materials Research - Part B Applied Biomaterials 112, e35445 (2024); https://doi.org/10.1002/jbm.b.35445.
抄録	In this study, we evaluated the drug release behavior of diameter customized TiO₂ nanotube layers fabricated by anodization with various applied voltage sequences: conventional constant applied potentials of 20 V (45 nm) and 60 V (80 nm), a 20/60 V stepped potential (50 nm [two-diameter]), and a 20–60 V swept potential (49 nm [full-tapered]) (values in parentheses indicate the inner tube diameter at the top part of nanotube layers). The structures of the 50 nm (two-diameter) and 49 nm (full-tapered) samples had smaller inner diameters at the top part of nanotube layers than that of the 80 nm sample, while the outer diameters at the bottom part of nanotube layers were almost the same size as the 80 nm sample. The 80 nm sample, which had the largest nanotube diameter and length, exhibited the greatest burst release, followed by the 50 nm (two-diameter), 49 nm (full-tapered), and 45 nm samples. The initial burst released drug amounts and release rates from the 50 nm (two-diameter) and 49 nm (full-tapered) samples were significantly suppressed by the smaller tube top. On the other hand, the largest proportion of the slow released drug amount to the total released drug amount was observed for the 50 nm (two-diameter) sample. Thus, 50 nm (two-diameter) achieved suppressed initial burst release and large storage capacity. Therefore, this study has, for the first time, applied TiO₂ nanotube layers with modulated diameters (two-diameter and full-tapered) to the realization of a localized drug delivery system (LDDS) with customized drug release properties.
出版者	John Wiley and Sons Inc
収録物名	Journal of Biomedical Materials Research - Part B Applied Biomaterials
巻(号)	112(7)
ページ	e35445
刊行年月	2024-07-01
言語	英語
ハンドルURL	https://hdl.handle.net/11094/97617
PISSN	15524973
eISSN	15524981
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1002/jbm.b.35445
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCTERMS.bibliographicCitation	Journal of Biomedical Materials Research - Part B Applied Biomaterials. 2024, 112(7), p. e35445
DC.title	TiO₂ nanotubes with customized diameters for local drug delivery systems
DC.creator	Miyabe, Sayaka
	Fujinaga, Yushi
	Tsuchiya, Hiroaki
	Fujimoto, Shinji
DC.publisher	John Wiley and Sons Inc
DC.language' scheme='DCTERMS.RFC1766	英語
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-07-01
DC.identifier	https://doi.org/10.1002/jbm.b.35445
DC.subject	anodization
	local drug delivery system
	oxide nanotubes
	TiO₂ nanotubes
DC.description	Miyabe S., Fujinaga Y., Tsuchiya H., et al. TiO₂ nanotubes with customized diameters for local drug delivery systems. Journal of Biomedical Materials Research - Part B Applied Biomaterials 112, e35445 (2024); https://doi.org/10.1002/jbm.b.35445.
DCTERMS.abstract	In this study, we evaluated the drug release behavior of diameter customized TiO₂ nanotube layers fabricated by anodization with various applied voltage sequences: conventional constant applied potentials of 20 V (45 nm) and 60 V (80 nm), a 20/60 V stepped potential (50 nm [two-diameter]), and a 20–60 V swept potential (49 nm [full-tapered]) (values in parentheses indicate the inner tube diameter at the top part of nanotube layers). The structures of the 50 nm (two-diameter) and 49 nm (full-tapered) samples had smaller inner diameters at the top part of nanotube layers than that of the 80 nm sample, while the outer diameters at the bottom part of nanotube layers were almost the same size as the 80 nm sample. The 80 nm sample, which had the largest nanotube diameter and length, exhibited the greatest burst release, followed by the 50 nm (two-diameter), 49 nm (full-tapered), and 45 nm samples. The initial burst released drug amounts and release rates from the 50 nm (two-diameter) and 49 nm (full-tapered) samples were significantly suppressed by the smaller tube top. On the other hand, the largest proportion of the slow released drug amount to the total released drug amount was observed for the 50 nm (two-diameter) sample. Thus, 50 nm (two-diameter) achieved suppressed initial burst release and large storage capacity. Therefore, this study has, for the first time, applied TiO₂ nanotube layers with modulated diameters (two-diameter and full-tapered) to the realization of a localized drug delivery system (LDDS) with customized drug release properties.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
DC.format	97617
citation_title	TiO₂ nanotubes with customized diameters for local drug delivery systems
citation_author	Miyabe, Sayaka
	Fujinaga, Yushi
	Tsuchiya, Hiroaki
	Fujimoto, Shinji
citation_publisher	John Wiley and Sons Inc
citation_language	英語
citation_date	2024-07-01
citation_journal_title	Journal of Biomedical Materials Research - Part B Applied Biomaterials
citation_volume	112
citation_issue	7
citation_firstpage	e35445
citation_doi	https://doi.org/10.1002/jbm.b.35445
citation_public_url	https://hdl.handle.net/11094/97617

TiO₂ nanotubes with customized diameters for local drug delivery systems

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