Correlation between plasma glutamate and adiponectin in patients with type 2 diabetes

Nagao, Hirofumi; Nishizawa, Hitoshi; Fukuda, Shiro et al.

Endocrine Journal, 2024, 71(1), 55-63

アクセス数:1,391件（2025-07-16 07:50 集計）

固定URL: https://hdl.handle.net/11094/97805

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タイトル
Correlation between plasma glutamate and adiponectin in patients with type 2 diabetes
著者
NRID
1000070983146 1000070983146
ORCID
0009-0001-1261-4160 0009-0001-1261-4160
researchmap permalink
Hirofumi_Nagao Hirofumi_Nagao
著者名
Nagao, Hirofumi
NRID
1000020379259 1000020379259
researchmap permalink
Hitoshi_Nishizawa Hitoshi_Nishizawa
Scopus Author ID
7102282682 7102282682
著者名
Nishizawa, Hitoshi
NRID
1000000896467 1000000896467
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sfukuda-ou sfukuda-ou
Scopus Author ID
55766129200 55766129200
著者名
Fukuda, Shiro
NRID
1000010779789 1000010779789
researchmap permalink
Yuya_Fujishima Yuya_Fujishima
Scopus Author ID
54410318600 54410318600
著者名
Fujishima, Yuya
NRID
1000010746572 1000010746572
ORCID
0000-0002-8937-0053 0000-0002-8937-0053
researchmap permalink
Shunbun_Kita Shunbun_Kita
Scopus Author ID
36873116500 36873116500
著者名
Kita, Shunbun
NRID
1000030506308 1000030506308
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Adiponectin Adiponectin
Scopus Author ID
7401561691 7401561691
著者名
Maeda, Norikazu
NRID
1000010432444 1000010432444
researchmap permalink
read0090438 read0090438
著者名
Bamba, Takeshi
NRID
1000040273594 1000040273594
ORCID
0000-0003-3069-5547 0000-0003-3069-5547
researchmap permalink
fukusaki-eiichiro fukusaki-eiichiro
Scopus Author ID
35473325000 35473325000
著者名
Fukusaki, Eiichiro
NRID
1000060346145 1000060346145
researchmap permalink
shimomura_i shimomura_i
Scopus Author ID
7006715546 7006715546
ORCID
0000-0002-0851-9603 0000-0002-0851-9603
著者名
Shimomura, Iichiro
キーワード等
Adiponectin
Glutamate
Obesity
Type 2 diabetes
Visceral fat accumulation
内容
Nagao H., Nishizawa H., Fukuda S., et al. Correlation between plasma glutamate and adiponectin in patients with type 2 diabetes. Endocrine Journal 71, 55 (2024); https://doi.org/10.1507/endocrj.EJ23-0506.
抄録
Visceral fat accumulation is a major determinant of type 2 diabetes mellitus and cardiovascular diseases. Recent studies have reported that glutamate is the most elevated amino acid in the plasma amino acid profile in patients with obesity and/or visceral fat accumulation. Here, we show the relationship between plasma glutamate and the clinical features of patients with type 2 diabetes. The study subjects were 62 (28 men and 34 women) Japanese patients with type 2 diabetes. Blood profiles, including glutamate and adiponectin (APN) levels and estimated visceral fat area (eVFA), were measured. We also evaluated the plasma amino acid levels in mice with or without obesity by GC/MS analysis. In patients with type 2 diabetes, plasma glutamate was positively correlated with BMI, eVFA, and fasting insulin but negatively correlated with APN and duration of diabetes. Additionally, multiple regression analysis revealed that plasma glutamate was a significant determinant of APN. The plasma glutamate level was most significantly increased in obese mice compared to control mice, and it was negatively correlated with APN. These results suggest that the level of plasma glutamate could be a strong indicator of adipocyte dysfunction in patients with type 2 diabetes.
出版者
Japan Endocrine Society
収録物名
Endocrine Journal
巻(号)
71(1)
ページ
55-63
刊行年月
2024-01-29
言語
英語
ハンドルURL
https://hdl.handle.net/11094/97805
PISSN
09188959
eISSN
13484540
関連情報 (isIdenticalTo)
DOI (出版社版)
https://doi.org/10.1507/endocrj.EJ23-0506
アクセス権
open access
権利情報
© The Japan Endocrine Society
This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
出版タイプ
Version of Record
カテゴリ
学術雑誌論文 Journal Article