A novel internal target volume definition based on velocity and time of respiratory target motion for external beam radiotherapy

Yamanaka, Masashi; Nishio, Teiji; Iwabuchi, Kohei; Nagata, Hironori

doi:https://doi.org/10.1007/s12194-024-00837-3

A novel internal target volume definition based on velocity and time of respiratory target motion for external beam radiotherapy

Yamanaka, Masashi; Nishio, Teiji; Iwabuchi, Kohei et al.

Radiological Physics and Technology, 2024

アクセス数:265件（2025-07-14 02:19 集計）

固定URL: https://hdl.handle.net/11094/98075

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論文情報

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タイトル	A novel internal target volume definition based on velocity and time of respiratory target motion for external beam radiotherapy
著者	著者名 Yamanaka, Masashi
	NRID 1000040415526 1000040415526 researchmap permalink 551214 551214 Scopus Author ID 55822203900 55822203900 著者名 Nishio, Teiji
	著者名 Iwabuchi, Kohei
	著者名 Nagata, Hironori
キーワード等	Internal target volume
	4DCT
	Target motion velocity
	Time
内容	This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s12194-024-00837-3.
抄録	This study aimed to develop a novel internal target volume (ITV) definition for respiratory motion targets, considering target motion velocity and time. The proposed ITV was evaluated in respiratory-gated radiotherapy. An ITV modified with target motion velocity and time (ITVvt) was defined as an ITV that includes a target motion based on target motion velocity and time. The target motion velocity was calculated using four-dimensional computed tomography (4DCT) images. The ITVvts were created from phantom and clinical 4DCT images. The phantom 4DCT images were acquired using a solid phantom that moved with a sinusoidal waveform (peak-to-peak amplitudes of 10 and 20 mm and cycles of 2–6 s). The clinical 4DCT images were obtained from eight lung cancer cases. In respiratory-gated radiotherapy, the ITVvt was compared with conventional ITVs for beam times of 0.5–2 s within the gating window. The conventional ITV was created by adding a uniform margin as the maximum motion within the gating window. In the phantom images, the maximum volume difference between the ITVvt and conventional ITV was –81.9%. In the clinical images, the maximum volume difference was –53.6%. Shorter respiratory cycles and longer BTs resulted in smaller ITVvt compared with the conventional ITV. Therefore, the proposed ITVvt plan could be used to reduce treatment volumes and doses to normal tissues.
出版者	Springer
収録物名	Radiological Physics and Technology
刊行年月	2024-09-13
言語	英語
ハンドルURL	https://hdl.handle.net/11094/98075
PISSN	18650333
eISSN	18650341
関連情報 (isVersionOf)	DOI (出版社版) https://doi.org/10.1007/s12194-024-00837-3
アクセス権	embargoed access
権利情報	The full-text file will be made open to the public on 13 September 2025 in accordance with the publisher's policy.
出版タイプ	Accepted Manuscript
カテゴリ	単行書 Book

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCTERMS.bibliographicCitation	Radiological Physics and Technology. 2024
DC.title	A novel internal target volume definition based on velocity and time of respiratory target motion for external beam radiotherapy
DC.creator	Yamanaka, Masashi
	Nishio, Teiji
	Iwabuchi, Kohei
	Nagata, Hironori
DC.publisher	Springer
DC.language' scheme='DCTERMS.RFC1766	英語
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-09-13
DC.identifier	https://doi.org/10.1007/s12194-024-00837-3
DC.subject	Internal target volume
	4DCT
	Target motion velocity
	Time
DC.description	This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s12194-024-00837-3.
DCTERMS.abstract	This study aimed to develop a novel internal target volume (ITV) definition for respiratory motion targets, considering target motion velocity and time. The proposed ITV was evaluated in respiratory-gated radiotherapy. An ITV modified with target motion velocity and time (ITVvt) was defined as an ITV that includes a target motion based on target motion velocity and time. The target motion velocity was calculated using four-dimensional computed tomography (4DCT) images. The ITVvts were created from phantom and clinical 4DCT images. The phantom 4DCT images were acquired using a solid phantom that moved with a sinusoidal waveform (peak-to-peak amplitudes of 10 and 20 mm and cycles of 2–6 s). The clinical 4DCT images were obtained from eight lung cancer cases. In respiratory-gated radiotherapy, the ITVvt was compared with conventional ITVs for beam times of 0.5–2 s within the gating window. The conventional ITV was created by adding a uniform margin as the maximum motion within the gating window. In the phantom images, the maximum volume difference between the ITVvt and conventional ITV was –81.9%. In the clinical images, the maximum volume difference was –53.6%. Shorter respiratory cycles and longer BTs resulted in smaller ITVvt compared with the conventional ITV. Therefore, the proposed ITVvt plan could be used to reduce treatment volumes and doses to normal tissues.
DC.rights	The full-text file will be made open to the public on 13 September 2025 in accordance with the publisher's policy.
DC.format	98075
citation_title	A novel internal target volume definition based on velocity and time of respiratory target motion for external beam radiotherapy
citation_author	Yamanaka, Masashi
	Nishio, Teiji
	Iwabuchi, Kohei
	Nagata, Hironori
citation_publisher	Springer
citation_language	英語
citation_date	2024-09-13
citation_journal_title	Radiological Physics and Technology
citation_doi	https://doi.org/10.1007/s12194-024-00837-3
citation_public_url	https://hdl.handle.net/11094/98075

A novel internal target volume definition based on velocity and time of respiratory target motion for external beam radiotherapy

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