Mesothelin promotes the migration of endometrioid carcinoma and is associated with the MELF pattern

Tahara, Shinichiro; Nojima, Satoshi; Takashima, Tsuyoshi et al.

Pathology - Research and Practice, 2024, 262, 155562

アクセス数:35件（2025-03-18 12:13 集計）

固定URL: https://hdl.handle.net/11094/98087

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論文情報

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タイトル
Mesothelin promotes the migration of endometrioid carcinoma and is associated with the MELF pattern
著者
NRID
1000020792584 1000020792584
ORCID
0000-0001-6134-3275 0000-0001-6134-3275
researchmap permalink
s_tahara s_tahara
Scopus Author ID
57189030096 57189030096
著者名
Tahara, Shinichiro
NRID
1000040528791 1000040528791
ORCID
0000-0002-5124-0026 0000-0002-5124-0026
researchmap permalink
snojima snojima
Scopus Author ID
16224082000 16224082000
著者名
Nojima, Satoshi
著者名
Takashima, Tsuyoshi
NRID
1000000346131 1000000346131
ORCID
0000-0002-4552-783X 0000-0002-4552-783X
researchmap permalink
read0092307 read0092307
Scopus Author ID
6506703054 6506703054
著者名
Okuzaki, Daisuke
NRID
1000010283772 1000010283772
ORCID
0000-0001-8490-3650 0000-0001-8490-3650
researchmap permalink
read0046454 read0046454
Scopus Author ID
7003914326 7003914326
著者名
Morii, Eiichi
キーワード等
cadherin-6
endometrioid carcinoma
MELF
mesothelin
migration
内容
Tahara S., Nojima S., Takashima T., et al. Mesothelin promotes the migration of endometrioid carcinoma and is associated with the MELF pattern. Pathology - Research and Practice 262, 155562 (2024); https://doi.org/10.1016/j.prp.2024.155562.
抄録
Mesothelin (MSLN) is expressed in the mesothelium in normal tissues but is overexpressed in various malignant tumors. In this study, we searched for genes that were more frequently expressed in cases of endometrioid carcinoma (EC) with the MELF (microcystic, elongated, and fragmented) pattern using laser microdissection and RNA sequencing, and found that MSLN was predominantly expressed in cases with the MELF pattern. The role of MSLN in EC was analyzed by generating MSLN-knockout and -knockdown EC cell lines. MSLN promoted migration and epithelial–mesenchymal transition (EMT). Moreover, we found that cadherin-6 (CDH6) expression was regulated by MSLN. MSLN is known to bind to cancer antigen 125 (CA125), and we found that CA125 can regulate CDH6 expression via MSLN. Immunohistochemical investigations showed that MSLN, CA125, and CDH6 expression levels were considerably elevated in EC with the MELF pattern. The expression of CA125 was similar to that of MSLN not only in terms of immunohistochemical staining intensity but also the blood level of CA125. Our results showed that MSLN contributes to the migration and EMT of EC cells through upstream CA125 and downstream CDH6. Therefore, MSLN has potential as a therapeutic target for EC with the MELF pattern.
出版者
Elsevier GmbH
収録物名
Pathology - Research and Practice
巻(号)
262
ページ
155562
刊行年月
2024-10-01
言語
英語
ハンドルURL
https://hdl.handle.net/11094/98087
PISSN
03440338
eISSN
16180631
関連情報 (isVersionOf)
DOI (出版社版)
https://doi.org/10.1016/j.prp.2024.155562
アクセス権
embargoed access
権利情報
© 2024. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
The full-text file will be made open to the public on 1 October 2025 in accordance with the publisher's policy.
出版タイプ
Accepted Manuscript
カテゴリ
学術雑誌論文 Journal Article