New perspective on the clinical and laboratory characteristics of rheumatoid pleural effusion: A 29-case series

Minoda, Saki Sada; Sada, Ryuichi Minoda; Akebo, Hiroyuki; Tsugihashi, Yukio; Hatta, Kazuhiro

doi:https://doi.org/10.1093/mr/roae082

New perspective on the clinical and laboratory characteristics of rheumatoid pleural effusion: A 29-case series

Minoda, Saki Sada; Sada, Ryuichi Minoda; Akebo, Hiroyuki et al.

Modern Rheumatology, 2024, 35(2), 249-255

アクセス数:342件（2025-07-01 22:08 集計）

固定URL: https://hdl.handle.net/11094/98224

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タイトル	New perspective on the clinical and laboratory characteristics of rheumatoid pleural effusion: A 29-case series
著者	著者名 Minoda, Saki Sada
	NRID 1000040961230 1000040961230 ORCID 0000-0002-1455-6822 0000-0002-1455-6822 researchmap permalink sadametal sadametal Scopus Author ID 59319135000 59319135000 著者名 Sada, Ryuichi Minoda
	著者名 Akebo, Hiroyuki
	NRID 1000080793984 1000080793984 著者名 Tsugihashi, Yukio
	著者名 Hatta, Kazuhiro
キーワード等	Lactate dehydrogenase
	pH
	pleural effusion
	pleurisy
	rheumatoid arthritis
内容	This is a pre-copyedited, author-produced version of an article accepted for publication in Modern Rheumatology following peer review. The version of record Minoda Saki Sada, Sada Ryuichi Minoda, Akebo Hiroyuki, et al. New perspective on the clinical and laboratory characteristics of rheumatoid pleural effusion: A 29-case series. Modern Rheumatology, (2024) is available online at: https://doi.org/10.1093/mr/roae082.
抄録	Objective: Rheumatoid pleural effusion (RPE) usually occurs in middle-aged men. Pleural fluid analyses have revealed high lactate dehydrogenase (LDH) levels and low pH and glucose levels in RPE. We aimed to investigate the clinical and laboratory features of patients with RPE since the beginning of the 21st century. Methods: Medical records of patients with RPE were reviewed between May 2006 and October 2021. The patients were divided into <60 year (younger) and ≥60 year (older) groups. Results: The younger group comprised 6 patients (median age 53.5 years, female 33%) and older group comprised 23 patients (median age 76 years, female 52.2%). Compared to the younger group, the older group had fewer cases of fever (83.3 versus 18.2%, P = .007) and chest pain (66.7 versus 8.7%, P = .008). In pleural fluid analysis, the older group presented higher pH (P = .004) and lower LDH levels (P = .044). Seven patients died during the follow-up period. Conclusion: Most patients with RPE were over 60 years of age, and approximately half of them were female. The pleural fluid analysis showed milder inflammation in older patients than in middle-aged patients. The mortality rate of patients with RPE was distinctly higher than that previously reported.
出版者	Oxford University Press (OUP)
収録物名	Modern Rheumatology
巻(号)	35(2)
ページ	249-255
刊行年月	2024-08-22
言語	英語
ハンドルURL	https://hdl.handle.net/11094/98224
PISSN	14397595
eISSN	14397609
関連情報 (isVersionOf)	DOI (出版社版) https://doi.org/10.1093/mr/roae082
アクセス権	embargoed access
権利情報	The full-text file will be made open to the public on 22 August 2025 in accordance with the publisher's policy.
出版タイプ	Accepted Manuscript
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCTERMS.bibliographicCitation	Modern Rheumatology. 2024, 35(2), p. 249-255
DC.title	New perspective on the clinical and laboratory characteristics of rheumatoid pleural effusion: A 29-case series
DC.creator	Minoda, Saki Sada
	Sada, Ryuichi Minoda
	Akebo, Hiroyuki
	Tsugihashi, Yukio
	Hatta, Kazuhiro
DC.publisher	Oxford University Press (OUP)
DC.language' scheme='DCTERMS.RFC1766	英語
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-08-22
DC.identifier	https://doi.org/10.1093/mr/roae082
DC.subject	Lactate dehydrogenase
	pH
	pleural effusion
	pleurisy
	rheumatoid arthritis
DC.description	This is a pre-copyedited, author-produced version of an article accepted for publication in Modern Rheumatology following peer review. The version of record Minoda Saki Sada, Sada Ryuichi Minoda, Akebo Hiroyuki, et al. New perspective on the clinical and laboratory characteristics of rheumatoid pleural effusion: A 29-case series. Modern Rheumatology, (2024) is available online at: https://doi.org/10.1093/mr/roae082.
DCTERMS.abstract	Objective: Rheumatoid pleural effusion (RPE) usually occurs in middle-aged men. Pleural fluid analyses have revealed high lactate dehydrogenase (LDH) levels and low pH and glucose levels in RPE. We aimed to investigate the clinical and laboratory features of patients with RPE since the beginning of the 21st century. Methods: Medical records of patients with RPE were reviewed between May 2006 and October 2021. The patients were divided into <60 year (younger) and ≥60 year (older) groups. Results: The younger group comprised 6 patients (median age 53.5 years, female 33%) and older group comprised 23 patients (median age 76 years, female 52.2%). Compared to the younger group, the older group had fewer cases of fever (83.3 versus 18.2%, P = .007) and chest pain (66.7 versus 8.7%, P = .008). In pleural fluid analysis, the older group presented higher pH (P = .004) and lower LDH levels (P = .044). Seven patients died during the follow-up period. Conclusion: Most patients with RPE were over 60 years of age, and approximately half of them were female. The pleural fluid analysis showed milder inflammation in older patients than in middle-aged patients. The mortality rate of patients with RPE was distinctly higher than that previously reported.
DC.rights	The full-text file will be made open to the public on 22 August 2025 in accordance with the publisher's policy.
DC.format	98224
citation_title	New perspective on the clinical and laboratory characteristics of rheumatoid pleural effusion: A 29-case series
citation_author	Minoda, Saki Sada
	Sada, Ryuichi Minoda
	Akebo, Hiroyuki
	Tsugihashi, Yukio
	Hatta, Kazuhiro
citation_publisher	Oxford University Press (OUP)
citation_language	英語
citation_date	2024-08-22
citation_journal_title	Modern Rheumatology
citation_volume	35
citation_issue	2
citation_firstpage	249
citation_lastpage	255
citation_doi	https://doi.org/10.1093/mr/roae082
citation_public_url	https://hdl.handle.net/11094/98224

New perspective on the clinical and laboratory characteristics of rheumatoid pleural effusion: A 29-case series

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