Effect of DNA methylation at the CTLA4 gene on the clinical status of autoimmune thyroid diseases

Ohtani, Hiroki; Inoue, Naoya; Iwatani, Yoshinori; Takeno, Yuri; Arakawa, Yuya; Hidaka, Yoh; Watanabe, Mikio

doi:https://doi.org/10.1016/j.clim.2024.110338

Effect of DNA methylation at the CTLA4 gene on the clinical status of autoimmune thyroid diseases

Ohtani, Hiroki; Inoue, Naoya; Iwatani, Yoshinori et al.

Clinical Immunology, 2024, 267, 110338

アクセス数:23件（2025-04-03 19:17 集計）

固定URL: https://hdl.handle.net/11094/98323

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タイトル	Effect of DNA methylation at the CTLA4 gene on the clinical status of autoimmune thyroid diseases
著者	著者名 Ohtani, Hiroki
	NRID 1000080710269 1000080710269 researchmap permalink nao1 nao1 著者名 Inoue, Naoya
	NRID 1000060168581 1000060168581 researchmap permalink read0013695 read0013695 著者名 Iwatani, Yoshinori
	著者名 Takeno, Yuri
	NRID 1000030733175 1000030733175 researchmap permalink ara-y ara-y 著者名 Arakawa, Yuya
	NRID 1000030243231 1000030243231 researchmap permalink Y99 Y99 Scopus Author ID 7102099529 7102099529 著者名 Hidaka, Yoh
	NRID 1000050294088 1000050294088 ORCID 0000-0001-5971-9296 0000-0001-5971-9296 researchmap permalink watanabemikio watanabemikio Scopus Author ID 55793188612 55793188612 著者名 Watanabe, Mikio
キーワード等	Autoimmune thyroid disease
	CTLA-4
	Methylation
	Severity
	Single nucleotide polymorphism
内容	Ohtani H., Inoue N., Iwatani Y., et al. Effect of DNA methylation at the CTLA4 gene on the clinical status of autoimmune thyroid diseases. Clinical Immunology 267, 110338 (2024); https://doi.org/10.1016/j.clim.2024.110338.
抄録	The pathogenesis and manifestation of autoimmune thyroid diseases (AITDs), Graves' disease (GD), and Hashimoto's disease (HD) are associated with T cell activation. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) plays a crucial role in the regulation of T cell activation. DNA methylation levels of eight CpG sites in the CTLA4 gene and expression levels of soluble CTLA-4 were examined. Methylation levels of +22 CpG and CT60 CpG-SNPs in patients with GD and HD with the CT60 GG genotype were lower than those in control subjects. Methylation levels of the-15 CpG sites were lower in patients with intractable GD than those in GD patients in remission. These results suggest that demethylation of +22 CpG and CT60 CpG-SNPs may be associated with susceptibility to GD and HD in subjects with the CTLA4 CT60 GG genotype, and that demethylation of −15 CpG may be associated with the intractability of GD.
出版者	Elsevier B.V.
収録物名	Clinical Immunology
巻(号)	267
ページ	110338
刊行年月	2024-10-01
言語	英語
ハンドルURL	https://hdl.handle.net/11094/98323
PISSN	15216616
eISSN	15217035
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1016/j.clim.2024.110338
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCTERMS.bibliographicCitation	Clinical Immunology. 2024, 267, p. 110338
DC.title	Effect of DNA methylation at the CTLA4 gene on the clinical status of autoimmune thyroid diseases
DC.creator	Ohtani, Hiroki
	Inoue, Naoya
	Iwatani, Yoshinori
	Takeno, Yuri
	Arakawa, Yuya
	Hidaka, Yoh
	Watanabe, Mikio
DC.publisher	Elsevier B.V.
DC.language' scheme='DCTERMS.RFC1766	英語
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-10-01
DC.identifier	https://doi.org/10.1016/j.clim.2024.110338
DC.subject	Autoimmune thyroid disease
	CTLA-4
	Methylation
	Severity
	Single nucleotide polymorphism
DC.description	Ohtani H., Inoue N., Iwatani Y., et al. Effect of DNA methylation at the CTLA4 gene on the clinical status of autoimmune thyroid diseases. Clinical Immunology 267, 110338 (2024); https://doi.org/10.1016/j.clim.2024.110338.
DCTERMS.abstract	The pathogenesis and manifestation of autoimmune thyroid diseases (AITDs), Graves' disease (GD), and Hashimoto's disease (HD) are associated with T cell activation. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) plays a crucial role in the regulation of T cell activation. DNA methylation levels of eight CpG sites in the CTLA4 gene and expression levels of soluble CTLA-4 were examined. Methylation levels of +22 CpG and CT60 CpG-SNPs in patients with GD and HD with the CT60 GG genotype were lower than those in control subjects. Methylation levels of the-15 CpG sites were lower in patients with intractable GD than those in GD patients in remission. These results suggest that demethylation of +22 CpG and CT60 CpG-SNPs may be associated with susceptibility to GD and HD in subjects with the CTLA4 CT60 GG genotype, and that demethylation of −15 CpG may be associated with the intractability of GD.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
DC.format	98323
citation_title	Effect of DNA methylation at the CTLA4 gene on the clinical status of autoimmune thyroid diseases
citation_author	Ohtani, Hiroki
	Inoue, Naoya
	Iwatani, Yoshinori
	Takeno, Yuri
	Arakawa, Yuya
	Hidaka, Yoh
	Watanabe, Mikio
citation_publisher	Elsevier B.V.
citation_language	英語
citation_date	2024-10-01
citation_journal_title	Clinical Immunology
citation_volume	267
citation_firstpage	110338
citation_doi	https://doi.org/10.1016/j.clim.2024.110338
citation_public_url	https://hdl.handle.net/11094/98323

Effect of DNA methylation at the CTLA4 gene on the clinical status of autoimmune thyroid diseases

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