学術雑誌論文

学術雑誌論文

Current Opinion in Cell Biology. 2024, 90, p. 102420

Direct quantitative perturbations of physical parameters in vivo to elucidate vertebrate embryo morphogenesis

Elsevier Ltd

英語

2024-10-01

https://doi.org/10.1016/j.ceb.2024.102420

Kato S., Shindo A. Direct quantitative perturbations of physical parameters in vivo to elucidate vertebrate embryo morphogenesis. Current Opinion in Cell Biology 90, 102420 (2024); https://doi.org/10.1016/j.ceb.2024.102420.

Physical parameters such as tissue interplay forces, luminal pressure, fluid flow, temperature, and electric fields are crucial regulators of embryonic morphogenesis. While significant attention has been given to cellular and molecular responses to these physical parameters, their roles in morphogenesis are not yet fully elucidated. This is largely due to a shortage of methods for spatiotemporal modulation and direct quantitative perturbation of physical parameters in embryos. Recent advancements addressing these challenges include microscopes equipped with devices to apply and adjust forces, direct perturbation of luminal pressure, and the application of micro-forces to targeted cells and cilia in vivo. These methods are critical for unveiling morphogenesis mechanisms, highlighting the importance of integrating molecular and physical approaches for a comprehensive understanding of morphogenesis.

This article is licensed under a Creative Commons Attribution 4.0 International License.

98330

Direct quantitative perturbations of physical parameters in vivo to elucidate vertebrate embryo morphogenesis

Elsevier Ltd

英語

2024-10-01

Current Opinion in Cell Biology

90

102420

https://doi.org/10.1016/j.ceb.2024.102420

https://hdl.handle.net/11094/98330