MicroRNA-130a-3p regulates osimertinib resistance by targeting runt-related transcription factor 3 in lung adenocarcinoma

Shintani, Takuya; Shun, Yu Ting; Toyozumi, Yuji et al.

Scientific Reports, 2024, 14, 24429

アクセス数:40件（2025-04-06 21:52 集計）

固定URL: https://hdl.handle.net/11094/98340

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タイトル
MicroRNA-130a-3p regulates osimertinib resistance by targeting runt-related transcription factor 3 in lung adenocarcinoma
著者
NRID
1000040762076 1000040762076
著者名
Shintani, Takuya
著者名
Shun, Yu Ting
著者名
Toyozumi, Yuji
NRID
1000070513935 1000070513935
ORCID
0000-0003-1870-9571 0000-0003-1870-9571
researchmap permalink
Kenji_Ikemura Kenji_Ikemura
Scopus Author ID
36783115100 36783115100
著者名
Ikemura, Kenji
NRID
1000060860062 1000060860062
researchmap permalink
shiroyama_t shiroyama_t
Scopus Author ID
36476578400 36476578400
著者名
Shiroyama, Takayuki
NRID
1000010570583 1000010570583
researchmap permalink
saxon-w saxon-w
Scopus Author ID
13404305500 13404305500
著者名
Nagatomo, Izumi
NRID
1000080707571 1000080707571
ORCID
0000-0002-2274-4962 0000-0002-2274-4962
researchmap permalink
_kj _kj
Scopus Author ID
13807151700 13807151700
著者名
Jingushi, Kentaro
NRID
1000040452388 1000040452388
researchmap permalink
yoshi10 yoshi10
Scopus Author ID
7404001848 7404001848
著者名
Takeda, Yoshito
NRID
1000010294125 1000010294125
researchmap permalink
read0051725 read0051725
Scopus Author ID
6602726311 6602726311
ORCID
0000-0003-4749-7117 0000-0003-4749-7117
著者名
Kumanogoh, Atsushi
NRID
1000070252426 1000070252426
researchmap permalink
read0042639 read0042639
Scopus Author ID
56856467300 56856467300
著者名
Okuda, Masahiro
キーワード等
Extracellular vesicles
Lung adenocarcinoma
MicroRNA-130a-3p
Osimertinib resistance
Runt-related transcription factor 3
内容
Shintani T., Shun Y.T., Toyozumi Y., et al. MicroRNA-130a-3p regulates osimertinib resistance by targeting runt-related transcription factor 3 in lung adenocarcinoma. Scientific Reports 14, 24429 (2024); https://doi.org/10.1038/s41598-024-76196-1.
抄録
Overcoming resistance to epidermal growth factor receptor tyrosine kinase inhibitors, including osimertinib, is urgent to improve lung cancer treatment outcomes. Extracellular vesicle (EV)-derived microRNAs (EV-miRNAs) play important roles in drug resistance and serve as promising biomarkers. In this study, we aimed to identify EV-miRNAs associated with osimertinib resistance and investigate their clinical relevance. The release of excess EVs was confirmed in the osimertinib-resistant lung adenocarcinoma cell line PC9OR. The exposure of PC9OR-derived EVs and EV-miRNAs to PC9 cells increased cell viability after osimertinib treatment. Microarray analysis revealed that miR-130a-3p was upregulated in EVs derived from PC9OR cells and another osimertinib-resistant cell line (H1975OR). Transfection with miR-130a-3p attenuated osimertinib-induced cytotoxicity and apoptosis in both PC9 and H1975 cells, whereas osimertinib resistance in PC9OR cells was reversed after miR-130a-3p inhibition. Bioinformatics analysis revealed that runt-related transcription factor 3 is a target gene of miR-130a-3p, and it induced osimertinib resistance in PC9 cells. Patients with lower baseline serum miR-130a-3p concentrations had longer progression-free survival. miR-130a-3p is a potential therapeutic target and a predictive biomarker of osimertinib resistance in adenocarcinomas.
出版者
Nature Research
収録物名
Scientific Reports
巻(号)
14
ページ
24429
刊行年月
2024-10-18
言語
英語
ハンドルURL
https://hdl.handle.net/11094/98340
eISSN
20452322
関連情報 (isIdenticalTo)
DOI (出版社版)
https://doi.org/10.1038/s41598-024-76196-1
アクセス権
open access
権利情報
This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
出版タイプ
Version of Record
カテゴリ
学術雑誌論文 Journal Article