学術雑誌論文

学術雑誌論文

Cell reports. 2024, 43(9), p. 114677

Spatial transcriptomics elucidates medulla niche supporting germinal center response in myasthenia gravis-associated thymoma

Cell Press

英語

2024-09-24

https://doi.org/10.1016/j.celrep.2024.114677

Yasumizu Y., Kinoshita M., Zhang M.J., et al. Spatial transcriptomics elucidates medulla niche supporting germinal center response in myasthenia gravis-associated thymoma. Cell reports 43, 114677 (2024); https://doi.org/10.1016/j.celrep.2024.114677.

Myasthenia gravis (MG) is etiologically associated with thymus abnormalities, but its pathology in the thymus remains unclear. In this study, we attempt to narrow down the features associated with MG using spatial transcriptome analysis of thymoma and thymic hyperplasia samples. We find that the majority of thymomas are constituted by the cortical region. However, the small medullary region is enlarged in seropositive thymomas and contains polygenic enrichment and MG-specific germinal center structures. Neuromuscular medullary thymic epithelial cells, previously identified as MG-specific autoantigen-producing cells, are enriched in the cortico-medullary junction. The medulla is characterized by a specific chemokine pattern and immune cell composition, including migratory dendritic cells and effector regulatory T cells. Similar germinal center structures and immune microenvironments are also observed in the thymic hyperplasia medulla. This study shows that the medulla and junction areas are linked to MG pathology and provides insights into future MG research.

This article is licensed under a Creative Commons Attribution 4.0 International License.

98360

Spatial transcriptomics elucidates medulla niche supporting germinal center response in myasthenia gravis-associated thymoma

Cell Press

英語

2024-09-24

Cell reports

43

9

114677

https://doi.org/10.1016/j.celrep.2024.114677

https://hdl.handle.net/11094/98360