学術雑誌論文

学術雑誌論文

Journal of Trauma and Acute Care Surgery. 2024, 97(4), p. 557-565

Plasma proteomics profile-based comparison of torso versus brain injury: A prospective cohort study

Lippincott Williams and Wilkins

英語

2024-10-01

https://doi.org/10.1097/TA.0000000000004356

Tachino J., Togami Y., Matsumoto H., et al. Plasma proteomics profile-based comparison of torso versus brain injury: A prospective cohort study. Journal of Trauma and Acute Care Surgery 97, 557 (2024); https://doi.org/10.1097/TA.0000000000004356.

BACKGROUND: Trauma-related deaths and posttraumatic sequelae are a global health concern, necessitating a deeper understanding of the pathophysiology to advance trauma therapy. Proteomics offers insights into identifying and analyzing plasma proteins associated with trauma and inflammatory conditions; however, current proteomic methods have limitations in accurately measuring low-abundance plasma proteins. This study compared plasma proteomics profiles of patients from different acute trauma subgroups to identify new therapeutic targets and devise better strategies for personalized medicine. METHODS: This prospective observational single-center cohort study was conducted between August 2020 and September 2021 in the intensive care unit of Osaka University Hospital in Japan. Enrolling 59 consecutive patients with blunt trauma, we meticulously analyzed plasma proteomics profiles in participants with torso or head trauma, comparing them with those of controls (mild trauma). Using the Olink Explore 3072 instrument (Olink Proteomics AB, Uppsala, Sweden), we identified five endotypes (α-ϵ) via unsupervised hierarchical clustering. RESULTS: The median time from injury to blood collection was 47 minutes [interquartile range, 36-64 minutes]. The torso trauma subgroup exhibited 26 unique proteins with significantly altered expression, while the head trauma subgroup showed 68 unique proteins with no overlap between the two. The identified endotypes included α (torso trauma, n = 8), β (young patients with brain injury, n = 5), γ (severe brain injury postsurgery, n = 8), δ (torso or brain trauma with mild hyperfibrinolysis, n = 18), and ϵ (minor trauma, n = 20). Patients with torso trauma showed changes in blood pressure, smooth muscle adaptation, hypermetabolism, and hypoxemia. Patients with traumatic brain injury had dysregulated blood coagulation and altered nerves regeneration and differentiation. CONCLUSION: This study identified unique plasma protein expression patterns in patients with torso trauma and traumatic brain injury, helping categorize five distinct endotypes. Our findings may offer new insights for clinicians, highlighting potential strategies for personalized medicine and improved trauma-related care. LEVEL OF EVIDENCE: Prognostic and Epidemiological; Level III.

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98362

Plasma proteomics profile-based comparison of torso versus brain injury: A prospective cohort study

Lippincott Williams and Wilkins

英語

2024-10-01

Journal of Trauma and Acute Care Surgery

97

4

557

565

https://doi.org/10.1097/TA.0000000000004356

https://hdl.handle.net/11094/98362