Experimental and theoretical energetics of walking molecular motors under fluctuating environments

Ariga, Takayuki; Tomishige, Michio; Mizuno, Daisuke

doi:https://doi.org/10.1007/s12551-020-00684-7

Experimental and theoretical energetics of walking molecular motors under fluctuating environments

Ariga, Takayuki; Tomishige, Michio; Mizuno, Daisuke

Biophysical Reviews, 2020, 12, 503-510

アクセス数:434件（2026-02-15 21:49 集計）

固定URL: https://hdl.handle.net/11094/98369

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タイトル	Experimental and theoretical energetics of walking molecular motors under fluctuating environments
著者	NRID 1000030452262 1000030452262 researchmap permalink ariga_takayuki ariga_takayuki ORCID 0000-0002-2045-5761 0000-0002-2045-5761 Scopus Author ID 21233267500 21233267500 著者名 Ariga, Takayuki
	NRID 1000050361530 1000050361530 著者名 Tomishige, Michio
	NRID 1000030452741 1000030452741 著者名 Mizuno, Daisuke
キーワード等	Fluctuation dissipation theorem
	Kinesin
	Molecular motor
	Nonequilibrium energetics
	Single molecule manipulation
内容	Ariga T., Tomishige M., Mizuno D. Experimental and theoretical energetics of walking molecular motors under fluctuating environments. Biophysical Reviews 12, 503 (2020); https://doi.org/10.1007/s12551-020-00684-7.
抄録	Molecular motors are nonequilibrium open systems that convert chemical energy to mechanical work. Their energetics are essential for various dynamic processes in cells, but largely remain unknown because fluctuations typically arising in small systems prevent investigation of the nonequilibrium behavior of the motors in terms of thermodynamics. Recently, Harada and Sasa proposed a novel equality to measure the dissipation of nonequilibrium small systems. By utilizing this equality, we have investigated the nonequilibrium energetics of the single-molecule walking motor kinesin-1. The dissipation from kinesin movement was measured through the motion of an attached probe particle and its response to external forces, indicating that large hidden dissipation exists. In this short review, aiming to readers who are not familiar with nonequilibrium physics, we briefly introduce the theoretical basis of the dissipation measurement as well as our recent experimental results and mathematical model analysis and discuss the physiological implications of the hidden dissipation in kinesin. In addition, further perspectives on the efficiency of motors are added by considering their actual working environment: living cells.
出版者	Springer
収録物名	Biophysical Reviews
巻(号)	12
ページ	503-510
刊行年月	2020-04-01
言語	英語
ハンドルURL	https://hdl.handle.net/11094/98369
PISSN	18672450
eISSN	18672469
関連情報 (isVersionOf)	DOI (出版社版) https://doi.org/10.1007/s12551-020-00684-7
アクセス権	open access
権利情報	© 2020, International Union for Pure and Applied Biophysics (IUPAB) and Springer-Verlag GmbH Germany, part of Springer Nature.
出版タイプ	Accepted Manuscript
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCTERMS.bibliographicCitation	Biophysical Reviews. 2020, 12, p. 503-510
DC.title	Experimental and theoretical energetics of walking molecular motors under fluctuating environments
DC.creator	Ariga, Takayuki
	Tomishige, Michio
	Mizuno, Daisuke
DC.publisher	Springer
DC.language' scheme='DCTERMS.RFC1766	英語
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2020-04-01
DC.identifier	https://doi.org/10.1007/s12551-020-00684-7
DC.subject	Fluctuation dissipation theorem
	Kinesin
	Molecular motor
	Nonequilibrium energetics
	Single molecule manipulation
DC.description	Ariga T., Tomishige M., Mizuno D. Experimental and theoretical energetics of walking molecular motors under fluctuating environments. Biophysical Reviews 12, 503 (2020); https://doi.org/10.1007/s12551-020-00684-7.
DCTERMS.abstract	Molecular motors are nonequilibrium open systems that convert chemical energy to mechanical work. Their energetics are essential for various dynamic processes in cells, but largely remain unknown because fluctuations typically arising in small systems prevent investigation of the nonequilibrium behavior of the motors in terms of thermodynamics. Recently, Harada and Sasa proposed a novel equality to measure the dissipation of nonequilibrium small systems. By utilizing this equality, we have investigated the nonequilibrium energetics of the single-molecule walking motor kinesin-1. The dissipation from kinesin movement was measured through the motion of an attached probe particle and its response to external forces, indicating that large hidden dissipation exists. In this short review, aiming to readers who are not familiar with nonequilibrium physics, we briefly introduce the theoretical basis of the dissipation measurement as well as our recent experimental results and mathematical model analysis and discuss the physiological implications of the hidden dissipation in kinesin. In addition, further perspectives on the efficiency of motors are added by considering their actual working environment: living cells.
DC.rights	© 2020, International Union for Pure and Applied Biophysics (IUPAB) and Springer-Verlag GmbH Germany, part of Springer Nature.
DC.format	98369
citation_title	Experimental and theoretical energetics of walking molecular motors under fluctuating environments
citation_author	Ariga, Takayuki
	Tomishige, Michio
	Mizuno, Daisuke
citation_publisher	Springer
citation_language	英語
citation_date	2020-04-01
citation_journal_title	Biophysical Reviews
citation_volume	12
citation_firstpage	503
citation_lastpage	510
citation_doi	https://doi.org/10.1007/s12551-020-00684-7
citation_public_url	https://hdl.handle.net/11094/98369

Experimental and theoretical energetics of walking molecular motors under fluctuating environments

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