Serum D-asparagine concentration adjusted for eGFR could serve as a novel screening tool for urothelial carcinoma

Yamamoto, Akinaru; Kawashima, Atsunari; Sakai, Shinsuke; Mita, Masashi; Sassi, Nesrine; Inoguchi, Shunsuke; Horibe, Yuki; Yoshimura, Akihiro; Tani, Masaru; Yutong, Liu; Okuda, Yohei; Oka, Toshiki; Uemura, Toshihiro; Yamamichi, Gaku; Ishizuya, Yu; Hayashi, Takuji; Yamamoto, Yoshiyuki; Kato, Taigo; Hatano, Koji; Kakuta, Yoichi; Imamura, Ryoichi; Takahara, Shiro; Kimura, Tomonori; Nonomura, Norio

doi:https://doi.org/10.1016/j.bbrc.2024.150701

Serum D-asparagine concentration adjusted for eGFR could serve as a novel screening tool for urothelial carcinoma

Yamamoto, Akinaru; Kawashima, Atsunari; Sakai, Shinsuke et al.

Biochemical and Biophysical Research Communications, 2024, 733, 150701

アクセス数:3,499件（2025-08-14 22:30 集計）

固定URL: https://hdl.handle.net/11094/98435

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タイトル	Serum D-asparagine concentration adjusted for eGFR could serve as a novel screening tool for urothelial carcinoma
著者	NRID 1000050909653 1000050909653 researchmap permalink ayamamoto ayamamoto ORCID 0000-0002-3565-5870 0000-0002-3565-5870 著者名 Yamamoto, Akinaru
	NRID 1000050746568 1000050746568 researchmap permalink akawashima akawashima Scopus Author ID 9846139400 9846139400 著者名 Kawashima, Atsunari
	NRID 1000060817360 1000060817360 著者名 Sakai, Shinsuke
	著者名 Mita, Masashi
	著者名 Sassi, Nesrine
	著者名 Inoguchi, Shunsuke
	NRID 1000080981977 1000080981977 著者名 Horibe, Yuki
	NRID 1000070981992 1000070981992 著者名 Yoshimura, Akihiro
	NRID 1000090981960 1000090981960 著者名 Tani, Masaru
	著者名 Yutong, Liu
	NRID 1000010964372 1000010964372 ORCID 0000-0001-9909-4200 0000-0001-9909-4200 researchmap permalink okudayohei okudayohei 著者名 Okuda, Yohei
	NRID 1000060964385 1000060964385 著者名 Oka, Toshiki
	NRID 1000060905941 1000060905941 著者名 Uemura, Toshihiro
	NRID 1000040882262 1000040882262 researchmap permalink urology-osaka-japan urology-osaka-japan 著者名 Yamamichi, Gaku
	NRID 1000000783854 1000000783854 researchmap permalink okiishi okiishi 著者名 Ishizuya, Yu
	NRID 1000050747079 1000050747079 researchmap permalink takuhaya takuhaya 著者名 Hayashi, Takuji
	NRID 1000090759557 1000090759557 researchmap permalink yoshi229 yoshi229 ORCID 0000-0002-1271-3521 0000-0002-1271-3521 著者名 Yamamoto, Yoshiyuki
	NRID 1000070648021 1000070648021 researchmap permalink taigokato taigokato Scopus Author ID 55414697500 55414697500 ORCID 0000-0002-8681-1407 0000-0002-8681-1407 著者名 Kato, Taigo
	NRID 1000060762234 1000060762234 researchmap permalink koji_hatano koji_hatano Scopus Author ID 14627167600 14627167600 著者名 Hatano, Koji
	NRID 1000040710116 1000040710116 researchmap permalink 987654321 987654321 ORCID 0000-0001-5339-4312 0000-0001-5339-4312 著者名 Kakuta, Yoichi
	NRID 1000040456976 1000040456976 著者名 Imamura, Ryoichi
	NRID 1000070179547 1000070179547 researchmap permalink read0080308 read0080308 著者名 Takahara, Shiro
	NRID 1000000631300 1000000631300 ORCID 0000-0001-8186-094X 0000-0001-8186-094X researchmap permalink KimuraUNM KimuraUNM 著者名 Kimura, Tomonori
	NRID 1000030263263 1000030263263 researchmap permalink read0185096 read0185096 Scopus Author ID 7005880662 7005880662 著者名 Nonomura, Norio
キーワード等	Biomarker
	Bladder cancer
	D-amino acid
	D-asparagine
	Liquid biopsy
	Urothelial carcinoma
内容	Yamamoto A., Kawashima A., Sakai S., et al. Serum D-asparagine concentration adjusted for eGFR could serve as a novel screening tool for urothelial carcinoma. Biochemical and Biophysical Research Communications 733, 150701 (2024); https://doi.org/10.1016/j.bbrc.2024.150701.
抄録	The sensitivity of currently available screening tools for urothelial carcinoma (UC) remains unsatisfactory particularly at early stages. Hence, we aimed to establish a novel blood-based screening tool for urothelial carcinoma. We measured serum D-amino acid levels in 108 and 192 patients with and without UC individuals in the derivation cohort, and 15 and 25 patients with and without UC in the validation cohort. Serum D-asparagine levels were significantly higher in patients with UC than in those without UC (p < 0.0001). We developed a novel screening equation for the diagnosis of urothelial carcinoma using D-asparagine in serum and estimated the glomerular filtration rate (eGFR). Serum D-asparagine levels adjusted for eGFR exhibited high performance in the diagnosis of UC (AUC-ROC, 0.869; sensitivity, 80.6 %; specificity, 82.7 %), even in early-stage UC (AUC-ROC: 0.859, sensitivity: 83.3 %, specificity: 82.3 %), which were previously misdiagnosed via urinary occult blood or urine cytology. This established strategy combined with urinary occult blood, improves diagnostic ability (sensitivity: 93.7 %, specificity: 70.1 %).
出版者	Elsevier B.V.
収録物名	Biochemical and Biophysical Research Communications
巻(号)	733
ページ	150701
刊行年月	2024-11-12
言語	英語
ハンドルURL	https://hdl.handle.net/11094/98435
PISSN	0006291X
eISSN	10902104
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1016/j.bbrc.2024.150701
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCTERMS.bibliographicCitation	Biochemical and Biophysical Research Communications. 2024, 733, p. 150701
DC.title	Serum D-asparagine concentration adjusted for eGFR could serve as a novel screening tool for urothelial carcinoma
DC.creator	Yamamoto, Akinaru
	Kawashima, Atsunari
	Sakai, Shinsuke
	Mita, Masashi
	Sassi, Nesrine
	Inoguchi, Shunsuke
	Horibe, Yuki
	Yoshimura, Akihiro
	Tani, Masaru
	Yutong, Liu
	Okuda, Yohei
	Oka, Toshiki
	Uemura, Toshihiro
	Yamamichi, Gaku
	Ishizuya, Yu
	Hayashi, Takuji
	Yamamoto, Yoshiyuki
	Kato, Taigo
	Hatano, Koji
	Kakuta, Yoichi
	Imamura, Ryoichi
	Takahara, Shiro
	Kimura, Tomonori
	Nonomura, Norio
DC.publisher	Elsevier B.V.
DC.language' scheme='DCTERMS.RFC1766	英語
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-11-12
DC.identifier	https://doi.org/10.1016/j.bbrc.2024.150701
DC.subject	Biomarker
	Bladder cancer
	D-amino acid
	D-asparagine
	Liquid biopsy
	Urothelial carcinoma
DC.description	Yamamoto A., Kawashima A., Sakai S., et al. Serum D-asparagine concentration adjusted for eGFR could serve as a novel screening tool for urothelial carcinoma. Biochemical and Biophysical Research Communications 733, 150701 (2024); https://doi.org/10.1016/j.bbrc.2024.150701.
DCTERMS.abstract	The sensitivity of currently available screening tools for urothelial carcinoma (UC) remains unsatisfactory particularly at early stages. Hence, we aimed to establish a novel blood-based screening tool for urothelial carcinoma. We measured serum D-amino acid levels in 108 and 192 patients with and without UC individuals in the derivation cohort, and 15 and 25 patients with and without UC in the validation cohort. Serum D-asparagine levels were significantly higher in patients with UC than in those without UC (p < 0.0001). We developed a novel screening equation for the diagnosis of urothelial carcinoma using D-asparagine in serum and estimated the glomerular filtration rate (eGFR). Serum D-asparagine levels adjusted for eGFR exhibited high performance in the diagnosis of UC (AUC-ROC, 0.869; sensitivity, 80.6 %; specificity, 82.7 %), even in early-stage UC (AUC-ROC: 0.859, sensitivity: 83.3 %, specificity: 82.3 %), which were previously misdiagnosed via urinary occult blood or urine cytology. This established strategy combined with urinary occult blood, improves diagnostic ability (sensitivity: 93.7 %, specificity: 70.1 %).
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	98435
citation_title	Serum D-asparagine concentration adjusted for eGFR could serve as a novel screening tool for urothelial carcinoma
citation_author	Yamamoto, Akinaru
	Kawashima, Atsunari
	Sakai, Shinsuke
	Mita, Masashi
	Sassi, Nesrine
	Inoguchi, Shunsuke
	Horibe, Yuki
	Yoshimura, Akihiro
	Tani, Masaru
	Yutong, Liu
	Okuda, Yohei
	Oka, Toshiki
	Uemura, Toshihiro
	Yamamichi, Gaku
	Ishizuya, Yu
	Hayashi, Takuji
	Yamamoto, Yoshiyuki
	Kato, Taigo
	Hatano, Koji
	Kakuta, Yoichi
	Imamura, Ryoichi
	Takahara, Shiro
	Kimura, Tomonori
	Nonomura, Norio
citation_publisher	Elsevier B.V.
citation_language	英語
citation_date	2024-11-12
citation_journal_title	Biochemical and Biophysical Research Communications
citation_volume	733
citation_firstpage	150701
citation_doi	https://doi.org/10.1016/j.bbrc.2024.150701
citation_public_url	https://hdl.handle.net/11094/98435

Serum D-asparagine concentration adjusted for eGFR could serve as a novel screening tool for urothelial carcinoma

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