Long-range enhancement for fluorescence and Raman spectroscopy using Ag nanoislands protected with column-structured silica overlayer

Minamikawa, Takeo; Sakaguchi, Reiko; Harada, Yoshinori; Tanioka, Hiroki; Inoue, Sota; Hase, Hideharu; Mori, Yasuo; Takamatsu, Tetsuro; Yamasaki, Yu; Morimoto, Yukihiro; Kawasaki, Masahiro; Kawasaki, Mitsuo

doi:https://doi.org/10.1038/s41377-024-01655-3

Long-range enhancement for fluorescence and Raman spectroscopy using Ag nanoislands protected with column-structured silica overlayer

Minamikawa, Takeo; Sakaguchi, Reiko; Harada, Yoshinori et al.

Light: Science and Applications, 2024, 13, 299

アクセス数:1,061件（2025-08-14 16:54 集計）

固定URL: https://hdl.handle.net/11094/98543

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タイトル	Long-range enhancement for fluorescence and Raman spectroscopy using Ag nanoislands protected with column-structured silica overlayer
著者	NRID 1000010637193 1000010637193 ORCID 0000-0003-3528-7163 0000-0003-3528-7163 researchmap permalink takeominamikawa takeominamikawa 著者名 Minamikawa, Takeo
	著者名 Sakaguchi, Reiko
	NRID 1000010381956 1000010381956 著者名 Harada, Yoshinori
	著者名 Tanioka, Hiroki
	著者名 Inoue, Sota
	著者名 Hase, Hideharu
	NRID 1000080212265 1000080212265 著者名 Mori, Yasuo
	NRID 1000040154900 1000040154900 著者名 Takamatsu, Tetsuro
	著者名 Yamasaki, Yu
	NRID 1000080607218 1000080607218 researchmap permalink morimoto07218 morimoto07218 著者名 Morimoto, Yukihiro
	NRID 1000070110723 1000070110723 著者名 Kawasaki, Masahiro
	NRID 1000050111927 1000050111927 著者名 Kawasaki, Mitsuo
内容	Minamikawa T., Sakaguchi R., Harada Y., et al. Long-range enhancement for fluorescence and Raman spectroscopy using Ag nanoislands protected with column-structured silica overlayer. Light: Science and Applications 13, 299 (2024); https://doi.org/10.1038/s41377-024-01655-3.
抄録	We demonstrate long-range enhancement of fluorescence and Raman scattering using a dense random array of Ag nanoislands (AgNIs) coated with column-structured silica (CSS) overlayer of over 100 nm thickness, namely, remote plasmonic-like enhancement (RPE). The CSS layer provides physical and chemical protection, reducing the impact between analyte molecules and metal nanostructures. RPE plates are fabricated with high productivity using sputtering and chemical immersion in gold(I)/halide solution. The RPE plate significantly enhances Raman scattering and fluorescence, even without proximity between analyte molecules and metal nanostructures. The maximum enhancement factors are 107-fold for Raman scattering and 102-fold for fluorescence. RPE is successfully applied to enhance fluorescence biosensing of intracellular signalling dynamics in HeLa cells and Raman histological imaging of oesophagus tissues. Our findings present an interesting deviation from the conventional near-field enhancement theory, as they cannot be readily explained within its framework. However, based on the phenomenological aspects we have demonstrated, the observed enhancement is likely associated with the remote resonant coupling between the localised surface plasmon of AgNIs and the molecular transition dipole of the analyte, facilitated through the CSS structure. Although further investigation is warranted to fully understand the underlying mechanisms, the RPE plate offers practical advantages, such as high productivity and biocompatibility, making it a valuable tool for biosensing and biomolecular analysis in chemistry, biology, and medicine. We anticipate that RPE will advance as a versatile analytical tool for enhanced biosensing using Raman and fluorescence analysis in various biological contexts.
出版者	Springer Nature
収録物名	Light: Science and Applications
巻(号)	13
ページ	299
刊行年月	2024-10-28
言語	英語
ハンドルURL	https://hdl.handle.net/11094/98543
PISSN	20955545
eISSN	20477538
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1038/s41377-024-01655-3
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCTERMS.bibliographicCitation	Light: Science and Applications. 2024, 13, p. 299
DC.title	Long-range enhancement for fluorescence and Raman spectroscopy using Ag nanoislands protected with column-structured silica overlayer
DC.creator	Minamikawa, Takeo
	Sakaguchi, Reiko
	Harada, Yoshinori
	Tanioka, Hiroki
	Inoue, Sota
	Hase, Hideharu
	Mori, Yasuo
	Takamatsu, Tetsuro
	Yamasaki, Yu
	Morimoto, Yukihiro
	Kawasaki, Masahiro
	Kawasaki, Mitsuo
DC.publisher	Springer Nature
DC.language' scheme='DCTERMS.RFC1766	英語
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-10-28
DC.identifier	https://doi.org/10.1038/s41377-024-01655-3
DC.description	Minamikawa T., Sakaguchi R., Harada Y., et al. Long-range enhancement for fluorescence and Raman spectroscopy using Ag nanoislands protected with column-structured silica overlayer. Light: Science and Applications 13, 299 (2024); https://doi.org/10.1038/s41377-024-01655-3.
DCTERMS.abstract	We demonstrate long-range enhancement of fluorescence and Raman scattering using a dense random array of Ag nanoislands (AgNIs) coated with column-structured silica (CSS) overlayer of over 100 nm thickness, namely, remote plasmonic-like enhancement (RPE). The CSS layer provides physical and chemical protection, reducing the impact between analyte molecules and metal nanostructures. RPE plates are fabricated with high productivity using sputtering and chemical immersion in gold(I)/halide solution. The RPE plate significantly enhances Raman scattering and fluorescence, even without proximity between analyte molecules and metal nanostructures. The maximum enhancement factors are 107-fold for Raman scattering and 102-fold for fluorescence. RPE is successfully applied to enhance fluorescence biosensing of intracellular signalling dynamics in HeLa cells and Raman histological imaging of oesophagus tissues. Our findings present an interesting deviation from the conventional near-field enhancement theory, as they cannot be readily explained within its framework. However, based on the phenomenological aspects we have demonstrated, the observed enhancement is likely associated with the remote resonant coupling between the localised surface plasmon of AgNIs and the molecular transition dipole of the analyte, facilitated through the CSS structure. Although further investigation is warranted to fully understand the underlying mechanisms, the RPE plate offers practical advantages, such as high productivity and biocompatibility, making it a valuable tool for biosensing and biomolecular analysis in chemistry, biology, and medicine. We anticipate that RPE will advance as a versatile analytical tool for enhanced biosensing using Raman and fluorescence analysis in various biological contexts.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	98543
citation_title	Long-range enhancement for fluorescence and Raman spectroscopy using Ag nanoislands protected with column-structured silica overlayer
citation_author	Minamikawa, Takeo
	Sakaguchi, Reiko
	Harada, Yoshinori
	Tanioka, Hiroki
	Inoue, Sota
	Hase, Hideharu
	Mori, Yasuo
	Takamatsu, Tetsuro
	Yamasaki, Yu
	Morimoto, Yukihiro
	Kawasaki, Masahiro
	Kawasaki, Mitsuo
citation_publisher	Springer Nature
citation_language	英語
citation_date	2024-10-28
citation_journal_title	Light: Science and Applications
citation_volume	13
citation_firstpage	299
citation_doi	https://doi.org/10.1038/s41377-024-01655-3
citation_public_url	https://hdl.handle.net/11094/98543

Long-range enhancement for fluorescence and Raman spectroscopy using Ag nanoislands protected with column-structured silica overlayer

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