Mechano-gradients drive morphogen-noise correction to ensure robust patterning

Aoki, Kana; Higuchi, Taiki; Akieda, Yuki; Matsubara, Kotone; Ohkawa, Yasuyuki; Ishitani, Tohru

doi:https://doi.org/10.1126/sciadv.adp2357

Mechano-gradients drive morphogen-noise correction to ensure robust patterning

Aoki, Kana; Higuchi, Taiki; Akieda, Yuki et al.

Science Advances, 2024, 10(46)

アクセス数:639件（2025-07-22 20:53 集計）

固定URL: https://hdl.handle.net/11094/98545

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タイトル	Mechano-gradients drive morphogen-noise correction to ensure robust patterning
著者	NRID 1000070904738 1000070904738 researchmap permalink kanaaoki kanaaoki Scopus Author ID 57188650523 57188650523 著者名 Aoki, Kana
	著者名 Higuchi, Taiki
	NRID 1000020770514 1000020770514 researchmap permalink akieda akieda Scopus Author ID 56606072400 56606072400 著者名 Akieda, Yuki
	著者名 Matsubara, Kotone
	NRID 1000080448430 1000080448430 著者名 Ohkawa, Yasuyuki
	NRID 1000040448428 1000040448428 ORCID 0000-0002-6200-7043 0000-0002-6200-7043 researchmap permalink read0148831 read0148831 Scopus Author ID 8079317200 8079317200 著者名 Ishitani, Tohru
内容	Aoki Kana, Higuchi Taiki, Akieda Yuki, et al. Mechano-gradients drive morphogen-noise correction to ensure robust patterning. Science Advances 10, 337 (2024); https://doi.org/10.1126/sciadv.adp2357.
抄録	Morphogen gradients instruct cells to pattern tissues. Although the mechanisms by which morphogens transduce chemical signals have been extensively studied, the roles and regulation of the physical communication between morphogen-receiver cells remain unclear. Here, we show that the Wnt/β-catenin–morphogen gradient, which patterns the embryonic anterior-posterior (AP) axis, generates intercellular tension gradients along the AP axis by controlling membrane cadherin levels in zebrafish embryos. This “mechano-gradient” is used for the cell competition–driven correction of noisy morphogen gradients. Naturally and artificially generated unfit cells, producing noisy Wnt/β-catenin gradients, induce local deformation of the mechano-gradients that activate mechanosensitive calcium channels in the neighboring fit cells, which then secrete annexin A1a to kill unfit cells. Thus, chemo-mechanical interconversion–mediated competitive communication between the morphogen-receiver cells ensures precise tissue patterning.
出版者	American Association for the Advancement of Science (AAAS)
収録物名	Science Advances
巻(号)	10(46)
刊行年月	2024-11-15
言語	英語
ハンドルURL	https://hdl.handle.net/11094/98545
eISSN	23752548
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1126/sciadv.adp2357
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCTERMS.bibliographicCitation	Science Advances. 2024, 10(46)
DC.title	Mechano-gradients drive morphogen-noise correction to ensure robust patterning
DC.creator	Aoki, Kana
	Higuchi, Taiki
	Akieda, Yuki
	Matsubara, Kotone
	Ohkawa, Yasuyuki
	Ishitani, Tohru
DC.publisher	American Association for the Advancement of Science (AAAS)
DC.language' scheme='DCTERMS.RFC1766	英語
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-11-15
DC.identifier	https://doi.org/10.1126/sciadv.adp2357
DC.description	Aoki Kana, Higuchi Taiki, Akieda Yuki, et al. Mechano-gradients drive morphogen-noise correction to ensure robust patterning. Science Advances 10, 337 (2024); https://doi.org/10.1126/sciadv.adp2357.
DCTERMS.abstract	Morphogen gradients instruct cells to pattern tissues. Although the mechanisms by which morphogens transduce chemical signals have been extensively studied, the roles and regulation of the physical communication between morphogen-receiver cells remain unclear. Here, we show that the Wnt/β-catenin–morphogen gradient, which patterns the embryonic anterior-posterior (AP) axis, generates intercellular tension gradients along the AP axis by controlling membrane cadherin levels in zebrafish embryos. This “mechano-gradient” is used for the cell competition–driven correction of noisy morphogen gradients. Naturally and artificially generated unfit cells, producing noisy Wnt/β-catenin gradients, induce local deformation of the mechano-gradients that activate mechanosensitive calcium channels in the neighboring fit cells, which then secrete annexin A1a to kill unfit cells. Thus, chemo-mechanical interconversion–mediated competitive communication between the morphogen-receiver cells ensures precise tissue patterning.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
DC.format	98545
citation_title	Mechano-gradients drive morphogen-noise correction to ensure robust patterning
citation_author	Aoki, Kana
	Higuchi, Taiki
	Akieda, Yuki
	Matsubara, Kotone
	Ohkawa, Yasuyuki
	Ishitani, Tohru
citation_publisher	American Association for the Advancement of Science (AAAS)
citation_language	英語
citation_date	2024-11-15
citation_journal_title	Science Advances
citation_volume	10
citation_issue	46
citation_doi	https://doi.org/10.1126/sciadv.adp2357
citation_public_url	https://hdl.handle.net/11094/98545

Mechano-gradients drive morphogen-noise correction to ensure robust patterning

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