Calvarial Thickening in Tuberous Sclerosis Complex

Kuroda, Hideki; Khoo, Hui Ming; Fujita, Yuya; Tominaga, Koji; Kagitani-Shimono, Kuriko; Hosomi, Koichi; Tani, Naoki; Oshino, Satoru; Wataya-Kaneda, Mari; Kishima, Haruhiko

doi:https://doi.org/10.1016/j.wneu.2024.09.130

Calvarial Thickening in Tuberous Sclerosis Complex

Kuroda, Hideki; Khoo, Hui Ming; Fujita, Yuya et al.

World Neurosurgery, 2024, 192, e460-e467

アクセス数:143件（2025-05-21 13:35 集計）

固定URL: https://hdl.handle.net/11094/98594

閲覧可能ファイル

ファイル	フォーマット	利用条件	サイズ	閲覧回数	利用開始日	説明	information
WorldNeurosurg_192_e460	pdf	なし	823 KB	24	2024.12.13

Creative Commons : 表示 - 非営利 - 改変禁止

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

タイトル	Calvarial Thickening in Tuberous Sclerosis Complex
著者	researchmap permalink kurodahideki kurodahideki 著者名 Kuroda, Hideki
	NRID 1000070591022 1000070591022 ORCID 0000-0002-4039-0520 0000-0002-4039-0520 researchmap permalink hmkhoo hmkhoo Scopus Author ID 55314143200 55314143200 著者名 Khoo, Hui Ming
	著者名 Fujita, Yuya
	著者名 Tominaga, Koji
	NRID 1000060403185 1000060403185 ORCID 0000-0001-9649-9499 0000-0001-9649-9499 researchmap permalink osaka_rengo osaka_rengo Scopus Author ID 13002542100 13002542100 著者名 Kagitani-Shimono, Kuriko
	NRID 1000070533800 1000070533800 researchmap permalink HosomiKoichi HosomiKoichi Scopus Author ID 23967898900 23967898900 ORCID 0000-0001-7731-3302 0000-0001-7731-3302 著者名 Hosomi, Koichi
	NRID 1000020598370 1000020598370 researchmap permalink n_taniOsakaUniv n_taniOsakaUniv Scopus Author ID 7103335692 7103335692 著者名 Tani, Naoki
	NRID 1000040403050 1000040403050 ORCID 0000-0002-4248-2322 0000-0002-4248-2322 researchmap permalink handai_ns_oshino handai_ns_oshino Scopus Author ID 6602717325 6602717325 著者名 Oshino, Satoru
	NRID 1000070397644 1000070397644 researchmap permalink 3031 3031 Scopus Author ID 6602902401 6602902401 著者名 Wataya-Kaneda, Mari
	NRID 1000010332743 1000010332743 researchmap permalink hkishima hkishima Scopus Author ID 6603783358 6603783358 ORCID 0000-0002-9041-2337 0000-0002-9041-2337 著者名 Kishima, Haruhiko
キーワード等	Craniotomy
	Skull thickening
	Tuberous sclerosis complex
内容	Kuroda H., Khoo H.M., Fujita Y., et al. Calvarial Thickening in Tuberous Sclerosis Complex. World Neurosurgery 192, e460 (2024); https://doi.org/10.1016/j.wneu.2024.09.130.
抄録	Background: Tuberous sclerosis complex (TSC)–related skeletal abnormalities are understudied. Awareness of skull thickening in patients with TSC is important from the surgical standpoint because a thick skull might complicate craniotomy. This study aimed to discover if patients with TSC are generally prone to skull thickening by retrospectively investigating the frequency and characteristics of skull thickening in these patients. Methods: Patients with TSC ages 10 to 60 years who underwent magnetic resonance imaging in the neurosurgery, dermatology, or pediatrics clinic between 2010 and 2021 were identified. Two control groups were used for comparison: one with patients with unruptured intracranial aneurysms to serve as control without antiseizure medication exposure and one with non-TSC epilepsy as control with antiseizure medication exposure. In all patients, thickness of frontal, parietal, temporal, and occipital bones was measured at a fixed location of each bone on T2-weighted axial images. Results: Inclusion criteria were fulfilled by 29 patients. Frontal and temporal bones of the TSC group were significantly thicker than those of either control group. Skull thickening was significantly associated with intracerebral calcification, but not with age, sex, or antiseizure medication exposure. Focal skull thickening was associated with the presence of a subcortical calcification. Conclusions: Patients with TSC have skull thickening, which is often linked to intracerebral calcification. The presence of skull thickening may require modification of surgical approach during craniotomy. Skull thickening and the underlying intracerebral calcification likely share a common precipitating factor given their relationship. Future studies are warranted to clarify the genetic underpinnings of this relationship and even broader skeletal abnormalities in TSC.
出版者	Elsevier Inc.
収録物名	World Neurosurgery
巻(号)	192
ページ	e460-e467
刊行年月	2024-12-01
言語	英語
ハンドルURL	https://hdl.handle.net/11094/98594
PISSN	18788750
eISSN	18788769
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1016/j.wneu.2024.09.130
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCTERMS.bibliographicCitation	World Neurosurgery. 2024, 192, p. e460-e467
DC.title	Calvarial Thickening in Tuberous Sclerosis Complex
DC.creator	Kuroda, Hideki
	Khoo, Hui Ming
	Fujita, Yuya
	Tominaga, Koji
	Kagitani-Shimono, Kuriko
	Hosomi, Koichi
	Tani, Naoki
	Oshino, Satoru
	Wataya-Kaneda, Mari
	Kishima, Haruhiko
DC.publisher	Elsevier Inc.
DC.language' scheme='DCTERMS.RFC1766	英語
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-12-01
DC.identifier	https://doi.org/10.1016/j.wneu.2024.09.130
DC.subject	Craniotomy
	Skull thickening
	Tuberous sclerosis complex
DC.description	Kuroda H., Khoo H.M., Fujita Y., et al. Calvarial Thickening in Tuberous Sclerosis Complex. World Neurosurgery 192, e460 (2024); https://doi.org/10.1016/j.wneu.2024.09.130.
DCTERMS.abstract	Background: Tuberous sclerosis complex (TSC)–related skeletal abnormalities are understudied. Awareness of skull thickening in patients with TSC is important from the surgical standpoint because a thick skull might complicate craniotomy. This study aimed to discover if patients with TSC are generally prone to skull thickening by retrospectively investigating the frequency and characteristics of skull thickening in these patients. Methods: Patients with TSC ages 10 to 60 years who underwent magnetic resonance imaging in the neurosurgery, dermatology, or pediatrics clinic between 2010 and 2021 were identified. Two control groups were used for comparison: one with patients with unruptured intracranial aneurysms to serve as control without antiseizure medication exposure and one with non-TSC epilepsy as control with antiseizure medication exposure. In all patients, thickness of frontal, parietal, temporal, and occipital bones was measured at a fixed location of each bone on T2-weighted axial images. Results: Inclusion criteria were fulfilled by 29 patients. Frontal and temporal bones of the TSC group were significantly thicker than those of either control group. Skull thickening was significantly associated with intracerebral calcification, but not with age, sex, or antiseizure medication exposure. Focal skull thickening was associated with the presence of a subcortical calcification. Conclusions: Patients with TSC have skull thickening, which is often linked to intracerebral calcification. The presence of skull thickening may require modification of surgical approach during craniotomy. Skull thickening and the underlying intracerebral calcification likely share a common precipitating factor given their relationship. Future studies are warranted to clarify the genetic underpinnings of this relationship and even broader skeletal abnormalities in TSC.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
DC.format	98594
citation_title	Calvarial Thickening in Tuberous Sclerosis Complex
citation_author	Kuroda, Hideki
	Khoo, Hui Ming
	Fujita, Yuya
	Tominaga, Koji
	Kagitani-Shimono, Kuriko
	Hosomi, Koichi
	Tani, Naoki
	Oshino, Satoru
	Wataya-Kaneda, Mari
	Kishima, Haruhiko
citation_publisher	Elsevier Inc.
citation_language	英語
citation_date	2024-12-01
citation_journal_title	World Neurosurgery
citation_volume	192
citation_firstpage	e460
citation_lastpage	e467
citation_doi	https://doi.org/10.1016/j.wneu.2024.09.130
citation_public_url	https://hdl.handle.net/11094/98594

Calvarial Thickening in Tuberous Sclerosis Complex

閲覧可能ファイル

論文情報

論文詳細を表示