Subclinical amyloid deposition in inflammatory bowel diseases: A two hospital study

Hamamoto, Yuichiro; Kido, Kansuke; Kawamura, Michihiro; Sekido, Yuki; Ogino, Takayuki; Yasuoka, Hironao; Iijima, Hideki; Mizushima, Tsunekazu

doi:https://doi.org/10.1016/j.prp.2024.155682

Subclinical amyloid deposition in inflammatory bowel diseases: A two hospital study

Hamamoto, Yuichiro; Kido, Kansuke; Kawamura, Michihiro et al.

Pathology - Research and Practice, 2024, 264, 155682

アクセス数:812件（2025-09-08 13:46 集計）

固定URL: https://hdl.handle.net/11094/98597

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タイトル	Subclinical amyloid deposition in inflammatory bowel diseases: A two hospital study
著者	ORCID 0000-0002-3511-760X 0000-0002-3511-760X researchmap permalink yhama yhama Scopus Author ID 57210885924 57210885924 著者名 Hamamoto, Yuichiro
	researchmap permalink kansukekido kansukekido 著者名 Kido, Kansuke
	著者名 Kawamura, Michihiro
	NRID 1000000781709 1000000781709 researchmap permalink 00781709 00781709 Scopus Author ID 57193691322 57193691322 著者名 Sekido, Yuki
	NRID 1000050597458 1000050597458 researchmap permalink togino04 togino04 Scopus Author ID 57200254430 57200254430 ORCID 0000-0001-5435-4144 0000-0001-5435-4144 著者名 Ogino, Takayuki
	著者名 Yasuoka, Hironao
	NRID 1000090444520 1000090444520 researchmap permalink _0719 _0719 著者名 Iijima, Hideki
	NRID 1000000527707 1000000527707 著者名 Mizushima, Tsunekazu
キーワード等	amyloid
	inflammatory bowel disease
	Crohn's disease
	ulcerative colitis
内容	Hamamoto Y., Kido K., Kawamura M., et al. Subclinical amyloid deposition in inflammatory bowel diseases: A two hospital study. Pathology - Research and Practice 264, 155682 (2024); https://doi.org/10.1016/j.prp.2024.155682.
抄録	Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), predominantly affects young patients and leads to intestinal complications. Amyloidosis, which involves abnormal protein deposition, is a serious complication of IBD, with a low incidence. Early detection of subclinical amyloid deposits is crucial for preventing fatal outcomes; however, routine investigations are lacking. We aimed to retrospectively examine subclinical amyloid deposition in adult patients with IBD. Surgical specimens from 249 patients with IBD were collected from the databases of two hospitals. The specimens were subjected to staining and immunohistochemistry, and clinical information was collected simultaneously. The amyloid positivity rate was 0.8 % in CD (1/131) and 0 % in UC (0/118) based on Congo red staining. The patient with amyloid deposits was a female in her 80 s who lacked a family history of amyloidosis. The subtype was amyloid A. Clinical history revealed intestinal resection in her 30 s and subsequent abdominal symptoms. To the best of our knowledge, this is the first study to collect >100 surgically examined specimens from adults with CD or UC. In older patients with a long and complex clinical course, aggressive analysis of amyloids would be better.
出版者	Elsevier BV
収録物名	Pathology - Research and Practice
巻(号)	264
ページ	155682
刊行年月	2024-12-01
言語	英語
ハンドルURL	https://hdl.handle.net/11094/98597
PISSN	03440338
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1016/j.prp.2024.155682
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCTERMS.bibliographicCitation	Pathology - Research and Practice. 2024, 264, p. 155682
DC.title	Subclinical amyloid deposition in inflammatory bowel diseases: A two hospital study
DC.creator	Hamamoto, Yuichiro
	Kido, Kansuke
	Kawamura, Michihiro
	Sekido, Yuki
	Ogino, Takayuki
	Yasuoka, Hironao
	Iijima, Hideki
	Mizushima, Tsunekazu
DC.publisher	Elsevier BV
DC.language' scheme='DCTERMS.RFC1766	英語
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-12-01
DC.identifier	https://doi.org/10.1016/j.prp.2024.155682
DC.subject	amyloid
	inflammatory bowel disease
	Crohn's disease
	ulcerative colitis
DC.description	Hamamoto Y., Kido K., Kawamura M., et al. Subclinical amyloid deposition in inflammatory bowel diseases: A two hospital study. Pathology - Research and Practice 264, 155682 (2024); https://doi.org/10.1016/j.prp.2024.155682.
DCTERMS.abstract	Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), predominantly affects young patients and leads to intestinal complications. Amyloidosis, which involves abnormal protein deposition, is a serious complication of IBD, with a low incidence. Early detection of subclinical amyloid deposits is crucial for preventing fatal outcomes; however, routine investigations are lacking. We aimed to retrospectively examine subclinical amyloid deposition in adult patients with IBD. Surgical specimens from 249 patients with IBD were collected from the databases of two hospitals. The specimens were subjected to staining and immunohistochemistry, and clinical information was collected simultaneously. The amyloid positivity rate was 0.8 % in CD (1/131) and 0 % in UC (0/118) based on Congo red staining. The patient with amyloid deposits was a female in her 80 s who lacked a family history of amyloidosis. The subtype was amyloid A. Clinical history revealed intestinal resection in her 30 s and subsequent abdominal symptoms. To the best of our knowledge, this is the first study to collect >100 surgically examined specimens from adults with CD or UC. In older patients with a long and complex clinical course, aggressive analysis of amyloids would be better.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
DC.format	98597
citation_title	Subclinical amyloid deposition in inflammatory bowel diseases: A two hospital study
citation_author	Hamamoto, Yuichiro
	Kido, Kansuke
	Kawamura, Michihiro
	Sekido, Yuki
	Ogino, Takayuki
	Yasuoka, Hironao
	Iijima, Hideki
	Mizushima, Tsunekazu
citation_publisher	Elsevier BV
citation_language	英語
citation_date	2024-12-01
citation_journal_title	Pathology - Research and Practice
citation_volume	264
citation_firstpage	155682
citation_doi	https://doi.org/10.1016/j.prp.2024.155682
citation_public_url	https://hdl.handle.net/11094/98597

Subclinical amyloid deposition in inflammatory bowel diseases: A two hospital study

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