Increased ACE2 and TMPRSS2 expression in ulcerative colitis

Hamamoto, Yuichiro; Kawamura, Michihiro; Uchida, Hiroki; Hiramatsu, Kazuhiro; Katori, Chiaki; Asai, Hinako; Egawa, Satoshi; Yoshida, Kyotaro

doi:https://doi.org/10.1016/j.prp.2024.155108

Increased ACE2 and TMPRSS2 expression in ulcerative colitis

Hamamoto, Yuichiro; Kawamura, Michihiro; Uchida, Hiroki et al.

Pathology Research and Practice, 2024, 254, 155108

アクセス数:645件（2026-02-16 00:39 集計）

固定URL: https://hdl.handle.net/11094/98829

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タイトル	Increased ACE2 and TMPRSS2 expression in ulcerative colitis
著者	ORCID 0000-0002-3511-760X 0000-0002-3511-760X researchmap permalink yhama yhama Scopus Author ID 57210885924 57210885924 著者名 Hamamoto, Yuichiro
	著者名 Kawamura, Michihiro
	著者名 Uchida, Hiroki
	著者名 Hiramatsu, Kazuhiro
	著者名 Katori, Chiaki
	著者名 Asai, Hinako
	著者名 Egawa, Satoshi
	著者名 Yoshida, Kyotaro
キーワード等	ACE2
	COVID-19
	Inflammatory bowel disease
	SARS-CoV-2
	TMPRSS2
	Ulcerative colitis
内容	Hamamoto Y., Kawamura M., Uchida H., et al. Increased ACE2 and TMPRSS2 expression in ulcerative colitis. Pathology Research and Practice 254, 155108 (2024); https://doi.org/10.1016/j.prp.2024.155108.
抄録	Ulcerative colitis (UC) is a cryptogenic inflammatory bowel disease, and there is an urgent need to elucidate its pathogenesis. ACE2 and TMPRSS2, the entry molecules of SARS-CoV-2, are reportedly associated with the disease; however, no consensus has been reached yet. In this study, we examined the expression of ACE2 and TMPRSS2 in colon and rectal specimens of UC. We collected colorectal specimens from 60 patients (30 patients with UC and 30 controls from 2018 to 2021) and analyzed the proportion and intensity of ACE2 and TMPRSS2 using immunohistochemistry. The results revealed a significant increase in the proportion of ACE2 expression and the intensity of TMPRSS2 expression in patients with UC. ACE2 and TMPRSS2 expression in UC remained unaffected by the COVID-19 pandemic. We demonstrated that ACE2 and TMPRSS2 are likely involved in the pathogenesis of UC.
出版者	Elsevier GmbH
収録物名	Pathology Research and Practice
巻(号)	254
ページ	155108
刊行年月	2024-02-01
言語	英語
ハンドルURL	https://hdl.handle.net/11094/98829
PISSN	03440338
eISSN	16180631
関連情報 (isVersionOf)	DOI (出版社版) https://doi.org/10.1016/j.prp.2024.155108
アクセス権	open access
権利情報	© 2024. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
出版タイプ	Accepted Manuscript
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCTERMS.bibliographicCitation	Pathology Research and Practice. 2024, 254, p. 155108
DC.title	Increased ACE2 and TMPRSS2 expression in ulcerative colitis
DC.creator	Hamamoto, Yuichiro
	Kawamura, Michihiro
	Uchida, Hiroki
	Hiramatsu, Kazuhiro
	Katori, Chiaki
	Asai, Hinako
	Egawa, Satoshi
	Yoshida, Kyotaro
DC.publisher	Elsevier GmbH
DC.language' scheme='DCTERMS.RFC1766	英語
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-02-01
DC.identifier	https://doi.org/10.1016/j.prp.2024.155108
DC.subject	ACE2
	COVID-19
	Inflammatory bowel disease
	SARS-CoV-2
	TMPRSS2
	Ulcerative colitis
DC.description	Hamamoto Y., Kawamura M., Uchida H., et al. Increased ACE2 and TMPRSS2 expression in ulcerative colitis. Pathology Research and Practice 254, 155108 (2024); https://doi.org/10.1016/j.prp.2024.155108.
DCTERMS.abstract	Ulcerative colitis (UC) is a cryptogenic inflammatory bowel disease, and there is an urgent need to elucidate its pathogenesis. ACE2 and TMPRSS2, the entry molecules of SARS-CoV-2, are reportedly associated with the disease; however, no consensus has been reached yet. In this study, we examined the expression of ACE2 and TMPRSS2 in colon and rectal specimens of UC. We collected colorectal specimens from 60 patients (30 patients with UC and 30 controls from 2018 to 2021) and analyzed the proportion and intensity of ACE2 and TMPRSS2 using immunohistochemistry. The results revealed a significant increase in the proportion of ACE2 expression and the intensity of TMPRSS2 expression in patients with UC. ACE2 and TMPRSS2 expression in UC remained unaffected by the COVID-19 pandemic. We demonstrated that ACE2 and TMPRSS2 are likely involved in the pathogenesis of UC.
DC.rights	© 2024. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
DC.format	98829
citation_title	Increased ACE2 and TMPRSS2 expression in ulcerative colitis
citation_author	Hamamoto, Yuichiro
	Kawamura, Michihiro
	Uchida, Hiroki
	Hiramatsu, Kazuhiro
	Katori, Chiaki
	Asai, Hinako
	Egawa, Satoshi
	Yoshida, Kyotaro
citation_publisher	Elsevier GmbH
citation_language	英語
citation_date	2024-02-01
citation_journal_title	Pathology Research and Practice
citation_volume	254
citation_firstpage	155108
citation_doi	https://doi.org/10.1016/j.prp.2024.155108
citation_public_url	https://hdl.handle.net/11094/98829

Increased ACE2 and TMPRSS2 expression in ulcerative colitis

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