Kikuchi Disease After SARS-CoV-2 Vaccination: A Case Report With Immunohistochemical Analyses

Hamamoto, Yuichiro; Kawamura, Michihiro; Mori, Hideo; Uchida, Hiroki; Hiramatsu, Kazuhiro; Katori, Chiaki; Asai, Hinako; Kawasaki, Hiroko; Minamino, Taishi; Hashimoto, Michiko; Nakatsuka, Shin-Ichi; Yoshida, Kyotaro

doi:https://doi.org/10.1177/10668969231212428

Kikuchi Disease After SARS-CoV-2 Vaccination: A Case Report With Immunohistochemical Analyses

Hamamoto, Yuichiro; Kawamura, Michihiro; Mori, Hideo et al.

International Journal of Surgical Pathology, 2024, 32(6), 1123-1128

アクセス数:1,342件（2026-02-15 20:22 集計）

固定URL: https://hdl.handle.net/11094/98830

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タイトル	Kikuchi Disease After SARS-CoV-2 Vaccination: A Case Report With Immunohistochemical Analyses
著者	ORCID 0000-0002-3511-760X 0000-0002-3511-760X researchmap permalink yhama yhama Scopus Author ID 57210885924 57210885924 著者名 Hamamoto, Yuichiro
	著者名 Kawamura, Michihiro
	著者名 Mori, Hideo
	著者名 Uchida, Hiroki
	著者名 Hiramatsu, Kazuhiro
	著者名 Katori, Chiaki
	著者名 Asai, Hinako
	著者名 Kawasaki, Hiroko
	著者名 Minamino, Taishi
	著者名 Hashimoto, Michiko
	NRID 1000090303940 1000090303940 著者名 Nakatsuka, Shin-Ichi
	著者名 Yoshida, Kyotaro
キーワード等	COVID-19
	Kikuchi disease
	lymph node
	SARS-CoV-2
	vaccine
内容	Hamamoto Y., Kawamura M., Mori H., et al. Kikuchi Disease After SARS-CoV-2 Vaccination: A Case Report With Immunohistochemical Analyses. International Journal of Surgical Pathology 32(6), 1123-1128 © 2023 The Author(s). DOI: 10.1177/10668969231212428.
抄録	SARS-CoV-2 vaccines have been administered in many countries after the COVID-19 pandemic. Lymphadenopathy is a side effect of SARS-CoV-2 vaccine. We report a rare example of Kikuchi disease in the cervical lymph nodes after SARS-CoV-2 vaccination. A 41-year-old man complained of a swollen neck and fever 9 days after the first dose of SARS-CoV-2 mRNA-1273 vaccine. Computed tomography revealed enlarged cervical lymph nodes. Fine needle aspiration and resection were performed, and the clinicopathological diagnosis was consistent with Kikuchi disease. Histologically, the resected lymph nodes lost their polarity, and many histiocytes were aggregated with karyorrhectic nuclear debris and apoptosis. SARS-CoV-2 positive cells were small lymphocytes detected by immunohistochemistry. This is the first report that demonstrated SARS-CoV-2 expression in Kikuchi disease post-SARS-CoV-2 vaccination.
出版者	SAGE Publications Inc.
収録物名	International Journal of Surgical Pathology
巻(号)	32(6)
ページ	1123-1128
刊行年月	2024-09-01
言語	英語
ハンドルURL	https://hdl.handle.net/11094/98830
PISSN	10668969
eISSN	19402465
関連情報 (isVersionOf)	DOI (出版社版) https://doi.org/10.1177/10668969231212428
アクセス権	open access
出版タイプ	Accepted Manuscript
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCTERMS.bibliographicCitation	International Journal of Surgical Pathology. 2024, 32(6), p. 1123-1128
DC.title	Kikuchi Disease After SARS-CoV-2 Vaccination: A Case Report With Immunohistochemical Analyses
DC.creator	Hamamoto, Yuichiro
	Kawamura, Michihiro
	Mori, Hideo
	Uchida, Hiroki
	Hiramatsu, Kazuhiro
	Katori, Chiaki
	Asai, Hinako
	Kawasaki, Hiroko
	Minamino, Taishi
	Hashimoto, Michiko
	Nakatsuka, Shin-Ichi
	Yoshida, Kyotaro
DC.publisher	SAGE Publications Inc.
DC.language' scheme='DCTERMS.RFC1766	英語
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-09-01
DC.identifier	https://doi.org/10.1177/10668969231212428
DC.subject	COVID-19
	Kikuchi disease
	lymph node
	SARS-CoV-2
	vaccine
DC.description	Hamamoto Y., Kawamura M., Mori H., et al. Kikuchi Disease After SARS-CoV-2 Vaccination: A Case Report With Immunohistochemical Analyses. International Journal of Surgical Pathology 32(6), 1123-1128 © 2023 The Author(s). DOI: 10.1177/10668969231212428.
DCTERMS.abstract	SARS-CoV-2 vaccines have been administered in many countries after the COVID-19 pandemic. Lymphadenopathy is a side effect of SARS-CoV-2 vaccine. We report a rare example of Kikuchi disease in the cervical lymph nodes after SARS-CoV-2 vaccination. A 41-year-old man complained of a swollen neck and fever 9 days after the first dose of SARS-CoV-2 mRNA-1273 vaccine. Computed tomography revealed enlarged cervical lymph nodes. Fine needle aspiration and resection were performed, and the clinicopathological diagnosis was consistent with Kikuchi disease. Histologically, the resected lymph nodes lost their polarity, and many histiocytes were aggregated with karyorrhectic nuclear debris and apoptosis. SARS-CoV-2 positive cells were small lymphocytes detected by immunohistochemistry. This is the first report that demonstrated SARS-CoV-2 expression in Kikuchi disease post-SARS-CoV-2 vaccination.
DC.format	98830
citation_title	Kikuchi Disease After SARS-CoV-2 Vaccination: A Case Report With Immunohistochemical Analyses
citation_author	Hamamoto, Yuichiro
	Kawamura, Michihiro
	Mori, Hideo
	Uchida, Hiroki
	Hiramatsu, Kazuhiro
	Katori, Chiaki
	Asai, Hinako
	Kawasaki, Hiroko
	Minamino, Taishi
	Hashimoto, Michiko
	Nakatsuka, Shin-Ichi
	Yoshida, Kyotaro
citation_publisher	SAGE Publications Inc.
citation_language	英語
citation_date	2024-09-01
citation_journal_title	International Journal of Surgical Pathology
citation_volume	32
citation_issue	6
citation_firstpage	1123
citation_lastpage	1128
citation_doi	https://doi.org/10.1177/10668969231212428
citation_public_url	https://hdl.handle.net/11094/98830

Kikuchi Disease After SARS-CoV-2 Vaccination: A Case Report With Immunohistochemical Analyses

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