Aberrant MUC Immunohistochemical Expressions in Inflammatory Bowel Diseases

Hamamoto, Yuichiro; Kawamura, Michihiro; Uchida, Hiroki; Takagahara, Kojiro; Katori, Chiaki; Asai, Hinako; Harada, Hiroshi; Shimizu, Shigeki; Morii, Eiichi; Yoshida, Kyotaro

doi:https://doi.org/10.1097/pai.0000000000001096

Aberrant MUC Immunohistochemical Expressions in Inflammatory Bowel Diseases

Hamamoto, Yuichiro; Kawamura, Michihiro; Uchida, Hiroki et al.

Applied Immunohistochemistry and Molecular Morphology, 2023, 31(2), 107-112

アクセス数:20件（2025-03-18 12:36 集計）

固定URL: https://hdl.handle.net/11094/98832

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タイトル	Aberrant MUC Immunohistochemical Expressions in Inflammatory Bowel Diseases
著者	ORCID 0000-0002-3511-760X 0000-0002-3511-760X researchmap permalink yhama yhama Scopus Author ID 57210885924 57210885924 著者名 Hamamoto, Yuichiro
	著者名 Kawamura, Michihiro
	著者名 Uchida, Hiroki
	著者名 Takagahara, Kojiro
	著者名 Katori, Chiaki
	著者名 Asai, Hinako
	著者名 Harada, Hiroshi
	NRID 1000030336672 1000030336672 著者名 Shimizu, Shigeki
	NRID 1000010283772 1000010283772 ORCID 0000-0001-8490-3650 0000-0001-8490-3650 researchmap permalink read0046454 read0046454 Scopus Author ID 7003914326 7003914326 著者名 Morii, Eiichi
	著者名 Yoshida, Kyotaro
キーワード等	crohn disease
	immunohistochemistry
	inflammatory bowel disease
	ischemic colitis
	MUC
	mucin
	ulcerative colitis
内容	This is a non-final version of an article published in final form in Hamamoto Y., Kawamura M., Uchida H., et al. Aberrant MUC Immunohistochemical Expressions in Inflammatory Bowel Diseases. Applied Immunohistochemistry and Molecular Morphology 31, 107 (2023); https://doi.org/10.1097/pai.0000000000001096.
抄録	Ulcerative colitis (UC) and Crohn disease (CD) are cryptogenic inflammatory bowel diseases that are suggestive of aberrant mucin (MUC) expression; however, their relationship remains unclear. Here, we examined aberrant MUC expression in intestinal samples from UC and CD patients in comparison to samples from patients with ischemic colitis and control groups. To study the expression of MUC1, MUC5AC, and MUC6 in different patient groups, we reviewed the slides stained with hematoxylin and eosin and performed immunohistochemistry. The results revealed that MUC1 was expressed more in the UC group and MUC6 in the CD group. No significant changes were observed in MUC expression in the ischemic colitis group. Overall, we demonstrated changes in MUC expression in UC and CD, which can help in the diagnosis and early clinical management of UC and CD.
出版者	Lippincott Williams and Wilkins
収録物名	Applied Immunohistochemistry and Molecular Morphology
巻(号)	31(2)
ページ	107-112
刊行年月	2023-02-01
言語	英語
ハンドルURL	https://hdl.handle.net/11094/98832
PISSN	15412016
eISSN	15334058
関連情報 (isVersionOf)	DOI (出版社版) https://doi.org/10.1097/pai.0000000000001096
アクセス権	open access
権利情報	© 2022 Lippincott Williams and Wilkins
出版タイプ	Accepted Manuscript
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCTERMS.bibliographicCitation	Applied Immunohistochemistry and Molecular Morphology. 2023, 31(2), p. 107-112
DC.title	Aberrant MUC Immunohistochemical Expressions in Inflammatory Bowel Diseases
DC.creator	Hamamoto, Yuichiro
	Kawamura, Michihiro
	Uchida, Hiroki
	Takagahara, Kojiro
	Katori, Chiaki
	Asai, Hinako
	Harada, Hiroshi
	Shimizu, Shigeki
	Morii, Eiichi
	Yoshida, Kyotaro
DC.publisher	Lippincott Williams and Wilkins
DC.language' scheme='DCTERMS.RFC1766	英語
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2023-02-01
DC.identifier	https://doi.org/10.1097/pai.0000000000001096
DC.subject	crohn disease
	immunohistochemistry
	inflammatory bowel disease
	ischemic colitis
	MUC
	mucin
	ulcerative colitis
DC.description	This is a non-final version of an article published in final form in Hamamoto Y., Kawamura M., Uchida H., et al. Aberrant MUC Immunohistochemical Expressions in Inflammatory Bowel Diseases. Applied Immunohistochemistry and Molecular Morphology 31, 107 (2023); https://doi.org/10.1097/pai.0000000000001096.
DCTERMS.abstract	Ulcerative colitis (UC) and Crohn disease (CD) are cryptogenic inflammatory bowel diseases that are suggestive of aberrant mucin (MUC) expression; however, their relationship remains unclear. Here, we examined aberrant MUC expression in intestinal samples from UC and CD patients in comparison to samples from patients with ischemic colitis and control groups. To study the expression of MUC1, MUC5AC, and MUC6 in different patient groups, we reviewed the slides stained with hematoxylin and eosin and performed immunohistochemistry. The results revealed that MUC1 was expressed more in the UC group and MUC6 in the CD group. No significant changes were observed in MUC expression in the ischemic colitis group. Overall, we demonstrated changes in MUC expression in UC and CD, which can help in the diagnosis and early clinical management of UC and CD.
DC.rights	© 2022 Lippincott Williams and Wilkins
DC.format	98832
citation_title	Aberrant MUC Immunohistochemical Expressions in Inflammatory Bowel Diseases
citation_author	Hamamoto, Yuichiro
	Kawamura, Michihiro
	Uchida, Hiroki
	Takagahara, Kojiro
	Katori, Chiaki
	Asai, Hinako
	Harada, Hiroshi
	Shimizu, Shigeki
	Morii, Eiichi
	Yoshida, Kyotaro
citation_publisher	Lippincott Williams and Wilkins
citation_language	英語
citation_date	2023-02-01
citation_journal_title	Applied Immunohistochemistry and Molecular Morphology
citation_volume	31
citation_issue	2
citation_firstpage	107
citation_lastpage	112
citation_doi	https://doi.org/10.1097/pai.0000000000001096
citation_public_url	https://hdl.handle.net/11094/98832

Aberrant MUC Immunohistochemical Expressions in Inflammatory Bowel Diseases

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