Usefulness of immunohistochemistry to distinguish between secretory carcinoma and acinic cell carcinoma in the salivary gland

Hamamoto, Yuichiro; Harada, Hiroshi; Kohara, Masaharu; Honma, Keiichiro; Nakatsuka, Shin-ichi; Morii, Eiichi

doi:https://doi.org/10.1007/s00795-020-00256-4

Usefulness of immunohistochemistry to distinguish between secretory carcinoma and acinic cell carcinoma in the salivary gland

Hamamoto, Yuichiro; Harada, Hiroshi; Kohara, Masaharu et al.

Medical Molecular Morphology, 2021, 54(1), 23-30

アクセス数:19件（2025-03-18 14:52 集計）

固定URL: https://hdl.handle.net/11094/98834

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タイトル	Usefulness of immunohistochemistry to distinguish between secretory carcinoma and acinic cell carcinoma in the salivary gland
著者	ORCID 0000-0002-3511-760X 0000-0002-3511-760X researchmap permalink yhama yhama Scopus Author ID 57210885924 57210885924 著者名 Hamamoto, Yuichiro
	著者名 Harada, Hiroshi
	ORCID 0009-0006-7636-5833 0009-0006-7636-5833 著者名 Kohara, Masaharu
	NRID 1000020505945 1000020505945 著者名 Honma, Keiichiro
	NRID 1000090303940 1000090303940 著者名 Nakatsuka, Shin-ichi
	NRID 1000010283772 1000010283772 ORCID 0000-0001-8490-3650 0000-0001-8490-3650 researchmap permalink read0046454 read0046454 Scopus Author ID 7003914326 7003914326 著者名 Morii, Eiichi
キーワード等	Acinic cell carcinoma
	ETV6-NTRK3
	Phosphorylated signal transducer and activator of transcription 5
	Salivary gland
	Secretory carcinoma
内容	This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s00795-020-00256-4.
抄録	Secretory carcinoma (SC) of the salivary gland is a relatively newly described disease, separate from acinic cell carcinoma (ACC), which frequently displays ETV6-NTRK3 gene fusion. However, the differences between SC and ACC remain unclear. Here, histological reevaluation of 12 formerly diagnosed ACC cases was performed, which yielded a new diagnosis of SC in four cases due to a lack of obvious acinar-like cells. Immunohistochemically, phosphorylated signal transducer and activator of transcription 5 (p-STAT5) was expressed in SC but not in ACC, whereas discovered on GIST-1 (DOG1) was expressed in ACC but not in SC. Molecular analysis was possible in three SC cases, of which two showed the ETV6-NTRK3 fusion transcript on reverse-transcription polymerase chain reaction, as well as breaks in the ETV6 gene on fluorescence in situ hybridization. However, the remaining SC cases did not show this fusion transcript. Recently, several reports have suggested that SC might not be adequately diagnosed if the focus is placed solely on the ETV6-NTRK3 fusion gene due to genetic diversity. In this regard, immunohistochemistry of p-STAT5 and DOG1 is expected to be a useful alternative diagnostic tool to discriminate SC from ACC.
出版者	Springer
収録物名	Medical Molecular Morphology
巻(号)	54(1)
ページ	23-30
刊行年月	2021-03-01
言語	英語
ハンドルURL	https://hdl.handle.net/11094/98834
PISSN	18601480
eISSN	18601499
関連情報 (isVersionOf)	DOI (出版社版) https://doi.org/10.1007/s00795-020-00256-4
アクセス権	open access
出版タイプ	Accepted Manuscript
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCTERMS.bibliographicCitation	Medical Molecular Morphology. 2021, 54(1), p. 23-30
DC.title	Usefulness of immunohistochemistry to distinguish between secretory carcinoma and acinic cell carcinoma in the salivary gland
DC.creator	Hamamoto, Yuichiro
	Harada, Hiroshi
	Kohara, Masaharu
	Honma, Keiichiro
	Nakatsuka, Shin-ichi
	Morii, Eiichi
DC.publisher	Springer
DC.language' scheme='DCTERMS.RFC1766	英語
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2021-03-01
DC.identifier	https://doi.org/10.1007/s00795-020-00256-4
DC.subject	Acinic cell carcinoma
	ETV6-NTRK3
	Phosphorylated signal transducer and activator of transcription 5
	Salivary gland
	Secretory carcinoma
DC.description	This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s00795-020-00256-4.
DCTERMS.abstract	Secretory carcinoma (SC) of the salivary gland is a relatively newly described disease, separate from acinic cell carcinoma (ACC), which frequently displays ETV6-NTRK3 gene fusion. However, the differences between SC and ACC remain unclear. Here, histological reevaluation of 12 formerly diagnosed ACC cases was performed, which yielded a new diagnosis of SC in four cases due to a lack of obvious acinar-like cells. Immunohistochemically, phosphorylated signal transducer and activator of transcription 5 (p-STAT5) was expressed in SC but not in ACC, whereas discovered on GIST-1 (DOG1) was expressed in ACC but not in SC. Molecular analysis was possible in three SC cases, of which two showed the ETV6-NTRK3 fusion transcript on reverse-transcription polymerase chain reaction, as well as breaks in the ETV6 gene on fluorescence in situ hybridization. However, the remaining SC cases did not show this fusion transcript. Recently, several reports have suggested that SC might not be adequately diagnosed if the focus is placed solely on the ETV6-NTRK3 fusion gene due to genetic diversity. In this regard, immunohistochemistry of p-STAT5 and DOG1 is expected to be a useful alternative diagnostic tool to discriminate SC from ACC.
DC.format	98834
citation_title	Usefulness of immunohistochemistry to distinguish between secretory carcinoma and acinic cell carcinoma in the salivary gland
citation_author	Hamamoto, Yuichiro
	Harada, Hiroshi
	Kohara, Masaharu
	Honma, Keiichiro
	Nakatsuka, Shin-ichi
	Morii, Eiichi
citation_publisher	Springer
citation_language	英語
citation_date	2021-03-01
citation_journal_title	Medical Molecular Morphology
citation_volume	54
citation_issue	1
citation_firstpage	23
citation_lastpage	30
citation_doi	https://doi.org/10.1007/s00795-020-00256-4
citation_public_url	https://hdl.handle.net/11094/98834

Usefulness of immunohistochemistry to distinguish between secretory carcinoma and acinic cell carcinoma in the salivary gland

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