Comprehensive assessment of supratentorial and infratentorial volumes in infants with myelomeningocele with and without Chiari malformation type II

Hashimoto, Hiroaki; Shimada, Makoto; Takemoto, Osamu et al.

Neuroradiology, 2024, 67(3), 755-765

アクセス数:490件（2026-02-15 20:22 集計）

固定URL: https://hdl.handle.net/11094/98837

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タイトル
Comprehensive assessment of supratentorial and infratentorial volumes in infants with myelomeningocele with and without Chiari malformation type II
著者
NRID
1000050770674 1000050770674
ORCID
0000-0003-4057-4466 0000-0003-4057-4466
researchmap permalink
yousyou0720 yousyou0720
Scopus Author ID
56922570200 56922570200
著者名
Hashimoto, Hiroaki
著者名
Shimada, Makoto
著者名
Takemoto, Osamu
NRID
1000090533795 1000090533795
著者名
Chiba, Yasuyoshi
キーワード等
Chiari malformation type II
CT
Myelomeningocele
Postnatal repair
Volumetric measurement
内容
The version of record of this article, first published in Neuroradiology, is available online at Publisher’s website: https://doi.org/10.1007/s00234-024-03514-9.
抄録
Purpose: Chiari malformation type II (CM-II) is a congenital anomaly commonly associated with myelomeningocele (MMC), a severe form of open spina dysraphism. This study aimed to evaluate both supratentorial and infratentorial volumes in MMC infants with and without CM-II. Methods: We conducted a single-center, retrospective study of 52 MMC infants treated between April 2006 and July 2023. Infants were classified as non-CM-II or CM-II based on the presence of cerebellar displacement. All patients underwent computed tomography (CT) at 0 months of age. Volumetric parameters included intracranial volume (ICV), lateral ventricles volume (LVV), posterior cranial fossa volume (PCFV), cerebellum volume (CBMV), and brainstem volume (BSV). LVV represented supratentorial structures, while PCFV, CBMV, and BSV represented infratentorial structures. Results: CM-II was diagnosed in 30 infants (57.7%). Correlation analysis revealed significant negative correlations between supratentorial (LVV) and infratentorial volumes (PCFV, CBMV, and BSV), and positive correlations among volumes within the same space(e.g., PCFV, CBMV, and BSV). CM-II infants exhibited significantly larger ICV (p = 0.04) and LVV (p < 0.001), but smaller PCFV (p < 0.001) and CBMV (p < 0.001) than non-CM-II infants. LVV was the best predictor for distinguishing non-CM-II from CM-II (area under the curve = 0.91). Conclusion: This study identified positive correlations within the same space and negative correlations between supratentorial and infratentorial volumes. LVV emerged as a critical indicator of CM-II, reflecting the relationship between reduced infratentorial space and enlarged supratentorial ventricles (hydrocephalus). These findings provide insights into the pathophysiology and clinical implications of CM-II in MMC patients.
出版者
Springer Science and Business Media Deutschland GmbH
収録物名
Neuroradiology
巻(号)
67(3)
ページ
755-765
刊行年月
2024-12-04
言語
英語
ハンドルURL
https://hdl.handle.net/11094/98837
PISSN
00283940
eISSN
14321920
関連情報 (isIdenticalTo)
DOI (出版社版)
https://doi.org/10.1007/s00234-024-03514-9
アクセス権
open access
権利情報
This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ
Version of Record
カテゴリ
学術雑誌論文 Journal Article