Recent advances in noncoding RNA modifications of gastrointestinal cancer

Hara, Tomoaki; Meng, Sikun; Arao, Yasuko; Saito, Yoshiko; Inoue, Kana; Rennie, Sarah; Ofusa, Ken; Doki, Yuichiro; Eguchi, Hidetoshi; Kitagawa, Toru; Ishii, Hideshi

doi:https://doi.org/10.1111/cas.16380

Recent advances in noncoding RNA modifications of gastrointestinal cancer

Hara, Tomoaki; Meng, Sikun; Arao, Yasuko et al.

Cancer Science, 2024

アクセス数:52件（2025-04-28 19:54 集計）

固定URL: https://hdl.handle.net/11094/98884

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タイトル	Recent advances in noncoding RNA modifications of gastrointestinal cancer
著者	NRID 1000030779161 1000030779161 researchmap permalink registered20221012 registered20221012 著者名 Hara, Tomoaki
	NRID 1000050977204 1000050977204 researchmap permalink sikunmeng sikunmeng 著者名 Meng, Sikun
	NRID 1000070962736 1000070962736 著者名 Arao, Yasuko
	著者名 Saito, Yoshiko
	著者名 Inoue, Kana
	著者名 Rennie, Sarah
	著者名 Ofusa, Ken
	NRID 1000020291445 1000020291445 researchmap permalink ydoki3251 ydoki3251 Scopus Author ID 7006390687 7006390687 著者名 Doki, Yuichiro
	NRID 1000090542118 1000090542118 researchmap permalink abcdabcdabcd abcdabcdabcd Scopus Author ID 7101627772 7101627772 著者名 Eguchi, Hidetoshi
	NRID 1000040314322 1000040314322 researchmap permalink torumd torumd 著者名 Kitagawa, Toru
	NRID 1000010280736 1000010280736 researchmap permalink read0103186 read0103186 Scopus Author ID 7402978600 7402978600 著者名 Ishii, Hideshi
キーワード等	circRNA
	gastrointestinal cancer
	lncRNA
	miRNA
	RNA modifications
内容	Hara T., Meng S., Arao Y., et al. Recent advances in noncoding RNA modifications of gastrointestinal cancer. Cancer Science, (2024); https://doi.org/10.1111/cas.16380.
抄録	Elucidating the mechanisms underlying cancer development and proliferation is important for the development of therapeutic methods for the complete cure of cancer. In particular, the identification of diagnostic markers for early detection and new therapeutic strategies for refractory gastrointestinal cancers are needed. Various abnormal phenomena occur in cancer cells, such as functional changes of proteins, led by genomic mutations, and changes in gene expression due to dysregulation of epigenetic regulation. This is no exception for noncoding RNA (ncRNA), which do not encode proteins. Recent reports have revealed that microRNA (miRNA), long noncoding RNA (lncRNA), and circular RNA (circRNA) are deeply involved in cancer progression. These ncRNAs have attracted attention as gene expression regulatory molecules. Recent advances in technology have made it possible not only to read DNA and RNA sequences but also to study the modification state of each base. In particular, comprehensive analysis of N6-methyladenosine (m⁶A) has been performed by many research groups, with multiple studies reporting that m⁶A modifications of specific genes are associated with cancer progression. Based on the above, this review examines how ncRNA modifications are related to cancer progression in gastrointestinal cancers such as colorectal and pancreatic cancer. We also discuss enzyme inhibitors that have been reported to have drug discovery potential targeting m⁶A modifications. By utilizing the new perspective of ncRNA modification, we may be able to accumulate knowledge on the molecular biology of cancer and contribute to human health through diagnosis and treatment.
出版者	John Wiley and Sons Inc
収録物名	Cancer Science
刊行年月	2024-11-01
言語	英語
ハンドルURL	https://hdl.handle.net/11094/98884
PISSN	13479032
eISSN	13497006
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1111/cas.16380
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCTERMS.bibliographicCitation	Cancer Science. 2024
DC.title	Recent advances in noncoding RNA modifications of gastrointestinal cancer
DC.creator	Hara, Tomoaki
	Meng, Sikun
	Arao, Yasuko
	Saito, Yoshiko
	Inoue, Kana
	Rennie, Sarah
	Ofusa, Ken
	Doki, Yuichiro
	Eguchi, Hidetoshi
	Kitagawa, Toru
	Ishii, Hideshi
DC.publisher	John Wiley and Sons Inc
DC.language' scheme='DCTERMS.RFC1766	英語
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-11-01
DC.identifier	https://doi.org/10.1111/cas.16380
DC.subject	circRNA
	gastrointestinal cancer
	lncRNA
	miRNA
	RNA modifications
DC.description	Hara T., Meng S., Arao Y., et al. Recent advances in noncoding RNA modifications of gastrointestinal cancer. Cancer Science, (2024); https://doi.org/10.1111/cas.16380.
DCTERMS.abstract	Elucidating the mechanisms underlying cancer development and proliferation is important for the development of therapeutic methods for the complete cure of cancer. In particular, the identification of diagnostic markers for early detection and new therapeutic strategies for refractory gastrointestinal cancers are needed. Various abnormal phenomena occur in cancer cells, such as functional changes of proteins, led by genomic mutations, and changes in gene expression due to dysregulation of epigenetic regulation. This is no exception for noncoding RNA (ncRNA), which do not encode proteins. Recent reports have revealed that microRNA (miRNA), long noncoding RNA (lncRNA), and circular RNA (circRNA) are deeply involved in cancer progression. These ncRNAs have attracted attention as gene expression regulatory molecules. Recent advances in technology have made it possible not only to read DNA and RNA sequences but also to study the modification state of each base. In particular, comprehensive analysis of N6-methyladenosine (m⁶A) has been performed by many research groups, with multiple studies reporting that m⁶A modifications of specific genes are associated with cancer progression. Based on the above, this review examines how ncRNA modifications are related to cancer progression in gastrointestinal cancers such as colorectal and pancreatic cancer. We also discuss enzyme inhibitors that have been reported to have drug discovery potential targeting m⁶A modifications. By utilizing the new perspective of ncRNA modification, we may be able to accumulate knowledge on the molecular biology of cancer and contribute to human health through diagnosis and treatment.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
DC.format	98884
citation_title	Recent advances in noncoding RNA modifications of gastrointestinal cancer
citation_author	Hara, Tomoaki
	Meng, Sikun
	Arao, Yasuko
	Saito, Yoshiko
	Inoue, Kana
	Rennie, Sarah
	Ofusa, Ken
	Doki, Yuichiro
	Eguchi, Hidetoshi
	Kitagawa, Toru
	Ishii, Hideshi
citation_publisher	John Wiley and Sons Inc
citation_language	英語
citation_date	2024-11-01
citation_journal_title	Cancer Science
citation_doi	https://doi.org/10.1111/cas.16380
citation_public_url	https://hdl.handle.net/11094/98884

Recent advances in noncoding RNA modifications of gastrointestinal cancer

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