Apelin is a marker of the progression of liver fibrosis and portal hypertension in patients with biliary atresia

Chen, Wei; Oue, Takaharu; Ueno, Takehisa; Uehara, Shuichiro; Usui, Noriaki; Fukuzawa, Masahiro

doi:https://doi.org/10.1007/s00383-012-3210-7

Apelin is a marker of the progression of liver fibrosis and portal hypertension in patients with biliary atresia

Chen, Wei; Oue, Takaharu; Ueno, Takehisa et al.

Pediatric Surgery International, 2013, 29, 79-85

アクセス数:540件（2025-07-26 12:22 集計）

固定URL: https://hdl.handle.net/11094/99832

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タイトル	Apelin is a marker of the progression of liver fibrosis and portal hypertension in patients with biliary atresia
著者	著者名 Chen, Wei
	NRID 1000050314315 1000050314315 著者名 Oue, Takaharu
	NRID 1000010456957 1000010456957 ORCID 0000-0002-4639-8814 0000-0002-4639-8814 researchmap permalink ueno-pedsurg ueno-pedsurg Scopus Author ID 21743992300 21743992300 著者名 Ueno, Takehisa
	NRID 1000000448060 1000000448060 著者名 Uehara, Shuichiro
	NRID 1000030273626 1000030273626 researchmap permalink read0194004 read0194004 著者名 Usui, Noriaki
	NRID 1000060165272 1000060165272 researchmap permalink read0106298 read0106298 著者名 Fukuzawa, Masahiro
キーワード等	Apelin
	APJ
	Biliary atresia
	Esophageal varices
	Liver fibrosis
	Liver transplantation
内容	This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s00383-012-3210-7
抄録	Purpose: Apelin, the endogenous ligand of the angiotensin-like-receptor 1 (APJ), is thought to play an important role in liver disease. This study investigated the apelin expression in different stages of biliary atresia (BA) and investigated whether it is associated with the progression of disease. Methods: Liver tissues were obtained from patients at Kasai's procedure (KP), the follow-up stage after KP (Post-KP) and at liver transplantation (LT). Immunohistochemistry for apelin and its receptor APJ and real-time quantitative reverse transcriptase polymerase chain reaction for apelin mRNA expression were conducted. Results: The immunohistochemical study revealed that apelin was mainly localized in the perivenular areas of control liver tissue, and slightly detected in the hepatic stellate cells (HSC) and hepatocytes, whereas intense apelin immunoreactivity was detected in perivenular areas, HSC and hepatocytes of LT liver tissue. The apelin mRNA expression level was significantly higher in the LT group than in the KP and Post-KP group. Significant linear correlations were observed between the apelin mRNA level and liver fibrosis, serum total bilirubin and the grade of esophageal varices. Conclusions: The hepatic apelin-APJ system is markedly activated in the progression of BA, especially in end-stage cirrhosis. The apelin expression level accurately reflects the severity of hepatic fibrosis and esophageal varices and therefore could be used as a prognostic factor in BA patients.
出版者	Springer Science and Business Media Deutschland GmbH
収録物名	Pediatric Surgery International
巻(号)	29
ページ	79-85
刊行年月	2013-01-01
言語	英語
ハンドルURL	https://hdl.handle.net/11094/99832
PISSN	01790358
eISSN	14379813
関連情報 (isVersionOf)	DOI (出版社版) https://doi.org/10.1007/s00383-012-3210-7
アクセス権	open access
権利情報	© 2012 Springer-Verlag Berlin Heidelberg
出版タイプ	Accepted Manuscript
カテゴリ	会議発表論文 Conference Paper

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCTERMS.bibliographicCitation	Pediatric Surgery International. 2013, 29, p. 79-85
DC.title	Apelin is a marker of the progression of liver fibrosis and portal hypertension in patients with biliary atresia
DC.creator	Chen, Wei
	Oue, Takaharu
	Ueno, Takehisa
	Uehara, Shuichiro
	Usui, Noriaki
	Fukuzawa, Masahiro
DC.publisher	Springer Science and Business Media Deutschland GmbH
DC.language' scheme='DCTERMS.RFC1766	英語
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2013-01-01
DC.identifier	https://doi.org/10.1007/s00383-012-3210-7
DC.subject	Apelin
	APJ
	Biliary atresia
	Esophageal varices
	Liver fibrosis
	Liver transplantation
DC.description	This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s00383-012-3210-7
DCTERMS.abstract	Purpose: Apelin, the endogenous ligand of the angiotensin-like-receptor 1 (APJ), is thought to play an important role in liver disease. This study investigated the apelin expression in different stages of biliary atresia (BA) and investigated whether it is associated with the progression of disease. Methods: Liver tissues were obtained from patients at Kasai's procedure (KP), the follow-up stage after KP (Post-KP) and at liver transplantation (LT). Immunohistochemistry for apelin and its receptor APJ and real-time quantitative reverse transcriptase polymerase chain reaction for apelin mRNA expression were conducted. Results: The immunohistochemical study revealed that apelin was mainly localized in the perivenular areas of control liver tissue, and slightly detected in the hepatic stellate cells (HSC) and hepatocytes, whereas intense apelin immunoreactivity was detected in perivenular areas, HSC and hepatocytes of LT liver tissue. The apelin mRNA expression level was significantly higher in the LT group than in the KP and Post-KP group. Significant linear correlations were observed between the apelin mRNA level and liver fibrosis, serum total bilirubin and the grade of esophageal varices. Conclusions: The hepatic apelin-APJ system is markedly activated in the progression of BA, especially in end-stage cirrhosis. The apelin expression level accurately reflects the severity of hepatic fibrosis and esophageal varices and therefore could be used as a prognostic factor in BA patients.
DC.rights	© 2012 Springer-Verlag Berlin Heidelberg
DC.format	99832
citation_title	Apelin is a marker of the progression of liver fibrosis and portal hypertension in patients with biliary atresia
citation_author	Chen, Wei
	Oue, Takaharu
	Ueno, Takehisa
	Uehara, Shuichiro
	Usui, Noriaki
	Fukuzawa, Masahiro
citation_publisher	Springer Science and Business Media Deutschland GmbH
citation_language	英語
citation_date	2013-01-01
citation_journal_title	Pediatric Surgery International
citation_volume	29
citation_firstpage	79
citation_lastpage	85
citation_doi	https://doi.org/10.1007/s00383-012-3210-7
citation_public_url	https://hdl.handle.net/11094/99832

Apelin is a marker of the progression of liver fibrosis and portal hypertension in patients with biliary atresia

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