Glomerulosclerosis Induced by in vivo Transfection of transforming Growth Factor-β or Platelet-derived Growth Factor Gene into the Rat Kidney

猪阪, 善隆

doi:https://doi.org/10.11501/3075052

Glomerulosclerosis Induced by in vivo Transfection of transforming Growth Factor-β or Platelet-derived Growth Factor Gene into the Rat Kidney

猪阪, 善隆

アクセス数:882件（2025-07-15 06:09 集計）

固定URL: https://doi.org/10.11501/3075052

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タイトル	Glomerulosclerosis Induced by in vivo Transfection of transforming Growth Factor-β or Platelet-derived Growth Factor Gene into the Rat Kidney
	TGF-β, PDGF遺伝子のラット腎へのin vivo遺伝子導入による糸球体硬化病変の発現
	TGF-β, PDGF イデンシノラットジンヘノ in vivo イデンシドウニュウニヨルイトキュウタイコウカビョウヘンノハッケン
著者	NRID 1000000379166 1000000379166 researchmap permalink isaka-handai3857 isaka-handai3857 Scopus Author ID 16207611100 16207611100 ORCID 0000-0002-0820-7167 0000-0002-0820-7167 著者名猪阪, 善隆 ; イサカ, ヨシタカ
抄録	Glomerulosclerosis, a final common lesion of various glomerular diseases, is characterized by mesangial cell proliferation and extracellular matrix (ECM) expansion. TGF-beta and PDGF are known to play a critical role in the regulation of ECM metabolism and mesenchymal cell proliferation, respectively. However, there is little evidence to demonstrate the direct role of each of these growth factors in the pathogenesis of glomerulosclerosis. Using an in vivo transfection technique, we could realize the selective overexpression of single growth factor in the kidney. The introduction of either TGF-beta or PDGF-B gene alone into the kidney induced glomerulosclerosis, although the patterns of action of these growth factors were different; TGF-beta affected ECM accumulation rather than cell proliferation and PDGF affected the latter rather than the former.
学位名	博士（医学）
学位授与年月日	1994-03-25
学位授与機関	大阪大学
研究科	医学
専攻	内科系
学位授与番号	甲第04965号
学位記番号	11283
言語	英語
ハンドルURL	https://hdl.handle.net/11094/3168
DOI	https://doi.org/10.11501/3075052
関連情報 (references)	URI http://www.jci.org/articles/view/116874
アクセス権	open access
権利情報	© 1993 Journal of Clinical Investigation
出版タイプ	Version of Record
カテゴリ	博士論文本文あり / 医学系研究科 / 1993年度
カテゴリ	博士論文 / 医学系研究科 / 1993年度

資源タイプ	博士論文
ローカル資源タイプ	博士論文本文あり
ローカル資源タイプ	博士論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	大阪大学, 1994, 博士論文
DC.title	Glomerulosclerosis Induced by in vivo Transfection of transforming Growth Factor-β or Platelet-derived Growth Factor Gene into the Rat Kidney
	TGF-β, PDGF遺伝子のラット腎へのin vivo遺伝子導入による糸球体硬化病変の発現
	TGF-β, PDGF イデンシノラットジンヘノ in vivo イデンシドウニュウニヨルイトキュウタイコウカビョウヘンノハッケン
DC.creator	猪阪, 善隆
DC.creator	イサカ, ヨシタカ
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DC.relation' scheme='DCTERMS.URI	http://www.jci.org/articles/view/116874
DCTERMS.abstract	Glomerulosclerosis, a final common lesion of various glomerular diseases, is characterized by mesangial cell proliferation and extracellular matrix (ECM) expansion. TGF-beta and PDGF are known to play a critical role in the regulation of ECM metabolism and mesenchymal cell proliferation, respectively. However, there is little evidence to demonstrate the direct role of each of these growth factors in the pathogenesis of glomerulosclerosis. Using an in vivo transfection technique, we could realize the selective overexpression of single growth factor in the kidney. The introduction of either TGF-beta or PDGF-B gene alone into the kidney induced glomerulosclerosis, although the patterns of action of these growth factors were different; TGF-beta affected ECM accumulation rather than cell proliferation and PDGF affected the latter rather than the former.
DCTERMS.issued' scheme='DCTERMS.W3CDTF	1994-03-25
DC.rights	© 1993 Journal of Clinical Investigation
DC.identifier	10.11501/3075052
DC.format	3168
citation_title	Glomerulosclerosis Induced by in vivo Transfection of transforming Growth Factor-β or Platelet-derived Growth Factor Gene into the Rat Kidney
citation_author	猪阪, 善隆
citation_language	英語
citation_public_url	https://hdl.handle.net/11094/3168
citation_abstract_html_url	http://www.jci.org/articles/view/116874
citation_date	1994-03-25
citation_doi_detail	10.11501/3075052
citation_doi	https://doi.org/10.11501/3075052

Glomerulosclerosis Induced by in vivo Transfection of transforming Growth Factor-β or Platelet-derived Growth Factor Gene into the Rat Kidney

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