Glomerulosclerosis Induced by in vivo Transfection of transforming Growth Factor-β or Platelet-derived Growth Factor Gene into the Rat Kidney

猪阪, 善隆

doi:info:doi/10.11501/3075052

資料種別: 博士論文本文あり Doctoral Thesis with Full Text
医学系研究科 / Graduate School of Medicine

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タイトル	Glomerulosclerosis Induced by in vivo Transfection of transforming Growth Factor-β or Platelet-derived Growth Factor Gene into the Rat Kidney
別タイトル	TGF-β, PDGF遺伝子のラット腎へのin vivo遺伝子導入による糸球体硬化病変の発現
タイトル (ヨミ)	TGF-β, PDGF イデンシノラットジンヘノ in vivo イデンシドウニュウニヨルイトキュウタイコウカビョウヘンノハッケン
著者	猪阪, 善隆猪阪, 善隆
著者 (ヨミ)	イサカ, ヨシタカ
抄録	Glomerulosclerosis, a final common lesion of various glomerular diseases, is characterized by mesangial cell proliferation and extracellular matrix (ECM) expansion. TGF-beta and PDGF are known to play a critical role in the regulation of ECM metabolism and mesenchymal cell proliferation, respectively. However, there is little evidence to demonstrate the direct role of each of these growth factors in the pathogenesis of glomerulosclerosis. Using an in vivo transfection technique, we could realize the selective overexpression of single growth factor in the kidney. The introduction of either TGF-beta or PDGF-B gene alone into the kidney induced glomerulosclerosis, although the patterns of action of these growth factors were different; TGF-beta affected ECM accumulation rather than cell proliferation and PDGF affected the latter rather than the former.
著者所属研究科	医学
専攻	内科系
学位名	博士（医学）
学位授与年月日	1994-03-25
学位授与機関	大阪大学
学位授与番号	14401甲第04965号
学位記番号	11283
URL	http://hdl.handle.net/11094/3168
関連情報 (references)	http://www.jci.org/articles/view/116874
権利情報	© 1993 Journal of Clinical Investigation
言語	英語
DOI	info:doi/10.11501/3075052

著者版フラグ	ETD
NII資源タイプ	学位論文
ローカル資源タイプ	博士論文本文あり
ローカル資源タイプ	博士論文
dcmi資源タイプ	text
DC.title	Glomerulosclerosis Induced by in vivo Transfection of transforming Growth Factor-β or Platelet-derived Growth Factor Gene into the Rat Kidney
DCTERMS.alternative	TGF-β, PDGF遺伝子のラット腎へのin vivo遺伝子導入による糸球体硬化病変の発現
DC.creator	猪阪, 善隆
DC.language" scheme="DCTERMS.RFC1766	英語
DC.identifier" scheme="DCTERMS.URI	http://hdl.handle.net/11094/3168
DCTERMS.abstract	Glomerulosclerosis, a final common lesion of various glomerular diseases, is characterized by mesangial cell proliferation and extracellular matrix (ECM) expansion. TGF-beta and PDGF are known to play a critical role in the regulation of ECM metabolism and mesenchymal cell proliferation, respectively. However, there is little evidence to demonstrate the direct role of each of these growth factors in the pathogenesis of glomerulosclerosis. Using an in vivo transfection technique, we could realize the selective overexpression of single growth factor in the kidney. The introduction of either TGF-beta or PDGF-B gene alone into the kidney induced glomerulosclerosis, although the patterns of action of these growth factors were different; TGF-beta affected ECM accumulation rather than cell proliferation and PDGF affected the latter rather than the former.
DCTERMS.issued" scheme="DCTERMS.W3CDTF	1994-03-25
DC.rights	© 1993 Journal of Clinical Investigation
DC.identifier	info:doi/10.11501/3075052
citation_title	Glomerulosclerosis Induced by in vivo Transfection of transforming Growth Factor-β or Platelet-derived Growth Factor Gene into the Rat Kidney
citation_author	猪阪, 善隆
citation_language	英語
citation_public_url	http://hdl.handle.net/11094/3168
citation_date	1994-03-25
citation_doi	info:doi/10.11501/3075052

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