Pathophysiological evaluations of initial plaque development after heart transplantation via serial multimodality imaging and cytokine assessments

Shiraki, Tatsuya; Ichibori, Yasuhiro; Ohtani, Tomohito; Mizote, Isamu; Kioka, Hidetaka; Tsukamoto, Yasumasa; Nakamura, Daisuke; Yokoi, Kensuke; Ide, Seiko; Nakamoto, Kei; Takeda, Yasuharu; Kotani, Jun-ichi; Hikoso, Shungo; Sawa, Yoshiki; Sakata, Yasushi

doi:https://doi.org/10.1016/j.healun.2022.03.007

Pathophysiological evaluations of initial plaque development after heart transplantation via serial multimodality imaging and cytokine assessments

Shiraki, Tatsuya; Ichibori, Yasuhiro; Ohtani, Tomohito et al.

Journal of Heart and Lung Transplantation, 2022, 41(7), 877-885

アクセス数:256件（2025-04-24 12:52 集計）

固定URL: https://hdl.handle.net/11094/90186

閲覧可能ファイル

ファイル	フォーマット	利用条件	サイズ	閲覧回数	利用開始日	説明	information
JHeartLungTransplant_41_7_877	pdf	なし	1.09 MB	101	2023.03.07

Creative Commons : 表示

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

タイトル	Pathophysiological evaluations of initial plaque development after heart transplantation via serial multimodality imaging and cytokine assessments
著者	NRID 1000060784056 1000060784056 ORCID 0000-0003-1901-1642 0000-0003-1901-1642 researchmap permalink shiraki shiraki Scopus Author ID 56012223900 56012223900 著者名 Shiraki, Tatsuya
	著者名 Ichibori, Yasuhiro
	NRID 1000030623897 1000030623897 researchmap permalink tohtani tohtani Scopus Author ID 57932819800 57932819800 著者名 Ohtani, Tomohito
	NRID 1000010584609 1000010584609 researchmap permalink mizoteisamu mizoteisamu Scopus Author ID 8266113500 8266113500 著者名 Mizote, Isamu
	NRID 1000070642099 1000070642099 researchmap permalink hkioka hkioka Scopus Author ID 36872909700 36872909700 著者名 Kioka, Hidetaka
	著者名 Tsukamoto, Yasumasa
	著者名 Nakamura, Daisuke
	著者名 Yokoi, Kensuke
	NRID 1000090624247 1000090624247 researchmap permalink seiko_osaka seiko_osaka Scopus Author ID 55793419500 55793419500 著者名 Ide, Seiko
	著者名 Nakamoto, Kei
	NRID 1000090572305 1000090572305 researchmap permalink takeda14 takeda14 Scopus Author ID 35398343900 35398343900 著者名 Takeda, Yasuharu
	著者名 Kotani, Jun-ichi
	NRID 1000030423164 1000030423164 researchmap permalink hikoso_osakauniv hikoso_osakauniv Scopus Author ID 6507288830 6507288830 著者名 Hikoso, Shungo
	NRID 1000000243220 1000000243220 researchmap permalink y-sawa0703 y-sawa0703 Scopus Author ID 55428162700 55428162700 著者名 Sawa, Yoshiki
	NRID 1000000397671 1000000397671 ORCID 0000-0002-5618-4721 0000-0002-5618-4721 researchmap permalink C4589 C4589 Scopus Author ID 35395964700 35395964700 著者名 Sakata, Yasushi
キーワード等	cardiac allograft vasculopathy
	heart transplantation
	interleukin-31
	intravascular ultrasound
	optical coherence tomography
内容	Shiraki T., Ichibori Y., Ohtani T., et al. Pathophysiological evaluations of initial plaque development after heart transplantation via serial multimodality imaging and cytokine assessments. Journal of Heart and Lung Transplantation 41, 877 (2022); https://doi.org/10.1016/j.healun.2022.03.007.
抄録	Background: Detailed morphological characteristics of de novo and donor-transmitted plaques and the association of serum T-lymphocyte cytokine levels with plaque progression of coronary allograft vasculopathy within 1 year after heart transplantation are unknown. Methods: In this retrospective analysis of data in a prospectively maintained database, 40 heart transplant recipients were included. We performed serial 3 vessel optical coherence tomography and intravascular ultrasound analyses, at the 8 week (baseline) and 12 month post-transplantation follow-ups, and serum cytokine measurements (n = 23). The correlation between serum cytokines and Δplaque burden (between baseline and follow-up) was evaluated depending on plaque morphology. Results: Thirteen de novo plaques (maximum intimal thickness ≥0.5 mm at the 12 month follow-up without plaques at baseline) were identified in 8 recipients, and 31 donor-transmitted plaques (maximum intimal thickness ≥0.5 mm at baseline) were detected in 17 recipients. Compared with donor-transmitted plaques, the Δplaque burden in the de novo plaques, with mainly fibrous morphology, was high (38.8% [29.6%–41.2%] vs 8.7% [1.33%–13.6%], p < 0.001). Stratification of the morphology of donor-transmitted plaques revealed that the Δplaque burden in fibrous plaques (10.6% [7.0%–18.0%]) was similar to that in fibroatheroma (10.3% [8.7%–23.8%]). Serum interleukin-31 levels at baseline correlated with fibrous plaque proliferation (r = 0.73, p = 0.007) even under immunosuppressive conditions, whereas other cytokines (interleukin-1β, interleukin-17, and interferon-gamma) were mostly undetectable. Conclusions: Intimal fibrous proliferation contributed to the progression of donor-transmitted and de novo plaques. Serum interleukin-31 levels at baseline may contribute to intimal fibrous proliferation within 1 year after heart transplantation.
出版者	Elsevier Inc.
収録物名	Journal of Heart and Lung Transplantation
巻(号)	41(7)
ページ	877-885
刊行年月	2022-07-01
言語	英語
ハンドルURL	https://hdl.handle.net/11094/90186
PISSN	10532498
eISSN	15573117
NCID	AA10796579
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1016/j.healun.2022.03.007
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Journal of Heart and Lung Transplantation. 2022, 41(7), p. 877-885
DC.title	Pathophysiological evaluations of initial plaque development after heart transplantation via serial multimodality imaging and cytokine assessments
DC.creator	Shiraki, Tatsuya
	Ichibori, Yasuhiro
	Ohtani, Tomohito
	Mizote, Isamu
	Kioka, Hidetaka
	Tsukamoto, Yasumasa
	Nakamura, Daisuke
	Yokoi, Kensuke
	Ide, Seiko
	Nakamoto, Kei
	Takeda, Yasuharu
	Kotani, Jun-ichi
	Hikoso, Shungo
	Sawa, Yoshiki
	Sakata, Yasushi
DC.publisher	Elsevier Inc.
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2022-07-01
DC.identifier	https://doi.org/10.1016/j.healun.2022.03.007
DC.subject	cardiac allograft vasculopathy
	heart transplantation
	interleukin-31
	intravascular ultrasound
	optical coherence tomography
DC.description	Shiraki T., Ichibori Y., Ohtani T., et al. Pathophysiological evaluations of initial plaque development after heart transplantation via serial multimodality imaging and cytokine assessments. Journal of Heart and Lung Transplantation 41, 877 (2022); https://doi.org/10.1016/j.healun.2022.03.007.
DCTERMS.abstract	Background: Detailed morphological characteristics of de novo and donor-transmitted plaques and the association of serum T-lymphocyte cytokine levels with plaque progression of coronary allograft vasculopathy within 1 year after heart transplantation are unknown. Methods: In this retrospective analysis of data in a prospectively maintained database, 40 heart transplant recipients were included. We performed serial 3 vessel optical coherence tomography and intravascular ultrasound analyses, at the 8 week (baseline) and 12 month post-transplantation follow-ups, and serum cytokine measurements (n = 23). The correlation between serum cytokines and Δplaque burden (between baseline and follow-up) was evaluated depending on plaque morphology. Results: Thirteen de novo plaques (maximum intimal thickness ≥0.5 mm at the 12 month follow-up without plaques at baseline) were identified in 8 recipients, and 31 donor-transmitted plaques (maximum intimal thickness ≥0.5 mm at baseline) were detected in 17 recipients. Compared with donor-transmitted plaques, the Δplaque burden in the de novo plaques, with mainly fibrous morphology, was high (38.8% [29.6%–41.2%] vs 8.7% [1.33%–13.6%], p < 0.001). Stratification of the morphology of donor-transmitted plaques revealed that the Δplaque burden in fibrous plaques (10.6% [7.0%–18.0%]) was similar to that in fibroatheroma (10.3% [8.7%–23.8%]). Serum interleukin-31 levels at baseline correlated with fibrous plaque proliferation (r = 0.73, p = 0.007) even under immunosuppressive conditions, whereas other cytokines (interleukin-1β, interleukin-17, and interferon-gamma) were mostly undetectable. Conclusions: Intimal fibrous proliferation contributed to the progression of donor-transmitted and de novo plaques. Serum interleukin-31 levels at baseline may contribute to intimal fibrous proliferation within 1 year after heart transplantation.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	90186
citation_title	Pathophysiological evaluations of initial plaque development after heart transplantation via serial multimodality imaging and cytokine assessments
citation_author	Shiraki, Tatsuya
	Ichibori, Yasuhiro
	Ohtani, Tomohito
	Mizote, Isamu
	Kioka, Hidetaka
	Tsukamoto, Yasumasa
	Nakamura, Daisuke
	Yokoi, Kensuke
	Ide, Seiko
	Nakamoto, Kei
	Takeda, Yasuharu
	Kotani, Jun-ichi
	Hikoso, Shungo
	Sawa, Yoshiki
	Sakata, Yasushi
citation_publisher	Elsevier Inc.
citation_language	英語
citation_date	2022-07-01
citation_journal_title	Journal of Heart and Lung Transplantation
citation_volume	41
citation_issue	7
citation_firstpage	877
citation_lastpage	885
citation_doi	https://doi.org/10.1016/j.healun.2022.03.007
citation_public_url	https://hdl.handle.net/11094/90186

Pathophysiological evaluations of initial plaque development after heart transplantation via serial multimodality imaging and cytokine assessments

閲覧可能ファイル

論文情報

論文詳細を表示