The heterodimer of 2-amino-1,8-naphthyridine and 3-aminoisoquinoline binds to the CTG/CTG triad via hydrogen bonding

Sakurabayashi, Shuhei; Yamada, Takeshi; Nakatani, Kazuhiko

Bioorganic and Medicinal Chemistry Letters, 2024, 114, 129985

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Identifier to cite or link to this item: https://hdl.handle.net/11094/100201

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Title
The heterodimer of 2-amino-1,8-naphthyridine and 3-aminoisoquinoline binds to the CTG/CTG triad via hydrogen bonding
Creator
ORCID
0000-0001-6561-2356 0000-0001-6561-2356
researchmap permalink
s-sakurabayashi s-sakurabayashi
CreatorName
Sakurabayashi, Shuhei
NRID
1000080633263 1000080633263
ORCID
0000-0003-3275-415X 0000-0003-3275-415X
researchmap permalink
tayamada tayamada
Scopus Author ID
55724848700 55724848700
CreatorName
Yamada, Takeshi
NRID
1000070237303 1000070237303
researchmap permalink
read0042668 read0042668
CreatorName
Nakatani, Kazuhiko
Subject
CTG repeat
Mismatched base pair
Nuclear Magnetic Resonance (NMR)
Small molecule ligand
Description
Sakurabayashi S., Yamada T., Nakatani K. The heterodimer of 2-amino-1,8-naphthyridine and 3-aminoisoquinoline binds to the CTG/CTG triad via hydrogen bonding. Bioorganic and Medicinal Chemistry Letters 114, 129985 (2024); https://doi.org/10.1016/j.bmcl.2024.129985.
Abstract
Myotonic dystrophy type 1 (DM1) is caused by the aberrant expansion of CTG repeats within the DMPK gene. This study investigated the potential binding of “X-linker-Y” type molecules to the CTG/CTG motif present in CTG repeats, using heterocyclic units X and Y capable of forming complementary hydrogen bonds with nucleobases. Among the tested molecules, the heterodimer of 2-amino-1,8-naphthyridine (X) and 3-aminoisoquinoline (Y) showed significant binding to the CTG/CTG motif. NMR analysis suggested hydrogen-bonded interactions between 3-aminoisoquinoline and thymine.
Publisher
Elsevier Ltd
Source Title
Bioorganic and Medicinal Chemistry Letters
Volume (Issue)
114
Page
129985
Date of Issued
2024-12-01
Language
English
Handle URL
https://hdl.handle.net/11094/100201
PISSN
0960894X
eISSN
14643405
Relation.isIdenticalTo
DOI (Publisher Version)
https://doi.org/10.1016/j.bmcl.2024.129985
Access Rights
open access
CopyRight
This article is licensed under a Creative Commons Attribution 4.0 International License.
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Category
学術雑誌論文 Journal Article