Genetic and epigenetic factors affecting carotid intima-media thickness in monozygotic twins

Mori, Saho; Arakawa, Yuya; Hasegawa, Mika et al.

Gene, 2025, 936, 149093

Number of Access:808（2025-10-31 07:06 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/100203

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Title
Genetic and epigenetic factors affecting carotid intima-media thickness in monozygotic twins
Creator
CreatorName
Mori, Saho
NRID
1000030733175 1000030733175
researchmap permalink
ara-y ara-y
CreatorName
Arakawa, Yuya
CreatorName
Hasegawa, Mika
CreatorName
Kato, Shiho
CreatorName
Hashimoto, Hinako
CreatorName
Yoshioka, Saki
NRID
1000030865746 1000030865746
researchmap permalink
hiromichiueda hiromichiueda
CreatorName
Ueda, Hiromichi
CreatorName
Research Group, Osaka Twin
NRID
1000050294088 1000050294088
ORCID
0000-0001-5971-9296 0000-0001-5971-9296
researchmap permalink
watanabemikio watanabemikio
Scopus Author ID
55793188612 55793188612
CreatorName
Watanabe, Mikio
Subject
Carotid ultrasonography
DNA methylation
Intima-media thickness
RNA sequencing
Single nucleotide polymorphisms
Subclinical atherosclerosis
Twin study
Description
Mori S., Arakawa Y., Hasegawa M., et al. Genetic and epigenetic factors affecting carotid intima-media thickness in monozygotic twins. Gene 936, 149093 (2025); https://doi.org/10.1016/j.gene.2024.149093.
Abstract
Background and aims: The intima-media thickness (IMT) of the carotid artery, an indicator of subclinical atherosclerosis, varies in close association with various factors such as diabetes and immune response. The extent of changes in IMT varies among individuals owing to both genetic and epigenetic factors. In this study, we aimed to identify single nucleotide polymorphisms (SNPs) and DNA methylation patterns that affect carotid IMT in monozygotic (MZ) twins. Methods: We measured the maximum IMT (IMT-Cmax) and the mean IMT in the common carotid artery wall using ultrasonography in 107 pairs of MZ twins recruited from the Osaka University Twin Registry. The genotyping of SNPs and the measurement of methylation levels were performed using a beads array, and the expression of each gene was determined by RNA sequencing. Linear regression analysis was performed on each of the two groups: one group consisted of twins randomly selected from each pair, and the other group consisted of co-twins. Results: We identified a CpG site (cg02432467) on HS3ST6 as a significant epigenetic factor in both IMT-Cmax and mean IMT analyses. The methylation level at another site (cg07927379) was negatively correlated with LINC01006 expression and IMT-Cmax. Furthermore, there were significant differences in AP2A2 expression and mean IMT among individuals with each genotype of the rs10902263 polymorphism. Conclusions: We identified genetic and epigenetic factors associated with carotid IMT that may be useful for individualized assessments.
Publisher
Elsevier B.V.
Source Title
Gene
Volume (Issue)
936
Page
149093
Date of Issued
2025-02-05
Language
English
Handle URL
https://hdl.handle.net/11094/100203
PISSN
03781119
eISSN
18790038
Relation.isIdenticalTo
DOI (Publisher Version)
https://doi.org/10.1016/j.gene.2024.149093
Access Rights
open access
CopyRight
This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
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Version of Record
Category
学術雑誌論文 Journal Article