Predictive value of enhanced corneal biomechanical parameters for ectasia progression

Koh, Shizuka; Ambrósio, Renato; Inoue, Ryota et al.

Japanese Journal of Ophthalmology, 2025

Number of Access:473（2025-08-19 00:56 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/100321

Link to primary information 

File Format Terms of use Size Views Date.Available Description information
JpnJOphthalmol_s10384-024-01149-0 pdf None 1.97 MB 16 2025.02.14  
Creative Commons : Attribution

Item Information

Output File Export EndNote Basic Export Mendeley

Title
Predictive value of enhanced corneal biomechanical parameters for ectasia progression
Creator
NRID
1000000570590 1000000570590
ORCID
0000-0002-5402-3051 0000-0002-5402-3051
researchmap permalink
skoh skoh
Scopus Author ID
7202061578 7202061578
CreatorName
Koh, Shizuka
CreatorName
Ambrósio, Renato
CreatorName
Inoue, Ryota
CreatorName
Belin, W. Michael
NRID
1000000273623 1000000273623
researchmap permalink
read0185086 read0185086
CreatorName
Maeda, Naoyuki
NRID
1000040244610 1000040244610
ORCID
0000-0001-9069-3610 0000-0001-9069-3610
researchmap permalink
read0131487 read0131487
Scopus Author ID
57211973404 57211973404
CreatorName
Nishida, Kohji
Description
The version of record of this article, first published in Japanese Journal of Ophthalmology, is available online at Publisher’s website: https://doi.org/s10384-024-01149-0.
Abstract
Purpose: To determine whether corneal biomechanical parameters can predict ectasia progression. Study design: Retrospective observational study. Methods:The baseline corneal biomechanical parameters of 64 eyes of 41 young patients (age, < 25 years at the first visit) who were diagnosed with keratoconus (KC) or suspected KC at Osaka University Hospital and followed up for more than two years were reviewed. Suspected KC was defined as borderline cases with no definitive clinical or topographical abnormalities in both eyes. The eyes were divided into progressed (P) and non-progressed (NP) groups using the ABCD grading system of Scheimpflug-based tomography. The Scheimpflug-based corneal biomechanical parameters evaluated included deformation amplitude ratio within 2 mm, integrated radius, Ambrósio relational thickness to the horizontal profile, stiffness parameter at the first applanation, stress–strain index, E-staging, and Corvis Biomechanical Index. The optimized tomographic/biomechanical index (TBIv2), Belin/Ambrósio Enhanced Ectasia Deviation (BAD-D), and inferior-superior axial steepening values from Scheimpflug-based tomography were also evaluated.Results: Twenty-three and 41 eyes were categorized into the P and NP groups, respectively. Logistic regression analysis showed that age, BAD-D, and TBIv2 could predict ectasia progression. The specificity, sensitivity, and area under the receiver operating characteristic curve (AUROC) values for BAD-D combined with age were 0.82, 0.60, and 0.83, respectively, whereas those for TBIv2 combined with age were 0.65, 0.82, and 0.82, respectively.Conclusions: Baseline TBIv2 is a potentially useful predictive marker for ectasia progression in young patients, whereas baseline BAD-D could be used for establishing a definitive diagnosis.
Publisher
Springer Science and Business Media LLC
Source Title
Japanese Journal of Ophthalmology
Date of Issued
2025-01-20
Language
English
Handle URL
https://hdl.handle.net/11094/100321
PISSN
00215155
eISSN
16132246
Relation.isIdenticalTo
DOI (Publisher Version)
https://doi.org/10.1007/s10384-024-01149-0
Access Rights
open access
CopyRight
This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version
Version of Record
Category
学術雑誌論文 Journal Article