Changes in swallowing response on patients undergoing chemoradiotherapy for head and neck cancer

Hashida, Nao; Suzuki, Motoyuki; Hosokawa, Kiyohito; Takenaka, Yukinori; Fukusumi, Takahito; Takemoto, Norihiko; Tanaka, Hidenori; Kitamura, Koji; Eguchi, Hirotaka; Umatani, Masanori; Kitayama, Itsuki; Nozawa, Masayuki; Kato, Chieri; Okajima, Eri; Inohara, Hidenori

doi:https://doi.org/10.1007/s00520-024-09134-6

Changes in swallowing response on patients undergoing chemoradiotherapy for head and neck cancer

Hashida, Nao; Suzuki, Motoyuki; Hosokawa, Kiyohito et al.

Supportive care in cancer, 2025, 33, 97

Number of Access:2,054（2025-08-14 12:35 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/100328

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Title	Changes in swallowing response on patients undergoing chemoradiotherapy for head and neck cancer
Creator	CreatorName Hashida, Nao
	NRID 1000050632329 1000050632329 researchmap permalink motoyukisuzuki motoyukisuzuki Scopus Author ID 55505806400 55505806400 CreatorName Suzuki, Motoyuki
	NRID 1000060625896 1000060625896 ORCID 0000-0002-5169-1038 0000-0002-5169-1038 researchmap permalink drink drink Scopus Author ID 55914870000 55914870000 CreatorName Hosokawa, Kiyohito
	NRID 1000040598398 1000040598398 ORCID 0000-0002-3135-5635 0000-0002-3135-5635 researchmap permalink yukinoritakenaka yukinoritakenaka Scopus Author ID 7102054128 7102054128 CreatorName Takenaka, Yukinori
	NRID 1000070623734 1000070623734 ORCID 0009-0002-1857-7548 0009-0002-1857-7548 researchmap permalink 2933 2933 Scopus Author ID 54893429600 54893429600 CreatorName Fukusumi, Takahito
	NRID 1000020636485 1000020636485 CreatorName Takemoto, Norihiko
	NRID 1000000804379 1000000804379 ORCID 0000-0002-7516-9180 0000-0002-7516-9180 researchmap permalink hidenoritanaka hidenoritanaka CreatorName Tanaka, Hidenori
	NRID 1000040804365 1000040804365 researchmap permalink kitamura1009 kitamura1009 CreatorName Kitamura, Koji
	researchmap permalink eguchi-hirotaka eguchi-hirotaka Scopus Author ID 57203344374 57203344374 CreatorName Eguchi, Hirotaka
	NRID 1000000804353 1000000804353 researchmap permalink muma_osaka muma_osaka CreatorName Umatani, Masanori
	ORCID 0009-0006-6551-2818 0009-0006-6551-2818 researchmap permalink itkktym itkktym CreatorName Kitayama, Itsuki
	CreatorName Nozawa, Masayuki
	CreatorName Kato, Chieri
	CreatorName Okajima, Eri
	NRID 1000000273657 1000000273657 researchmap permalink read0046473 read0046473 Scopus Author ID 7004501837 7004501837 CreatorName Inohara, Hidenori
Subject	Acute side effect
	Delayed swallowing initiation
	Swallowing response
Description	The version of record of this article, first published in Supportive care in cancer, is available online at Publisher’s website: https://doi.org/10.1007/s00520-024-09134-6.
Abstract	PURPOSE: Chemoradiotherapy (CRT) for head and neck cancer (HNC) often causes dysphagia. The risk of dysphagia increases during CRT tends to become more severe after finishing CRT, and persists for a few weeks thereafter. Thus, understanding the changes in swallowing physiology during and immediately after CRT is essential. This study aimed to clarify the changes in the swallowing response during and early after CRT and identify associated factors. METHODS: This retrospective study enrolled 107 patients with HNC who underwent CRT. We measured pharyngeal delay time (PDT) and laryngeal elevation delay time (LEDT) as indicators of the timing of the swallowing response at three time points: at CRT initiation (baseline), at 40-Gy irradiation during CRT (mid-CRT) and within 2 weeks following the completion of CRT (early post-CRT) as primary outcomes; and subgroup analyses based on clinical parameters, such as tumor sites, T stage, N stage, and opioid use at 40-Gy irradiation as secondary outcomes. RESULTS: Both PDT and LEDT were significantly prolonged between baseline and mid-CRT (PDT: p = 0.003, LEDT: p = 0.002) and between baseline and early post-CRT (PDT, p = 0.001; LEDT, p < 0.001). N2c/N3 and opioid use at 40-Gy irradiation showed prolonged PDT and LEDT at mid-CRT and early post-CRT. CONCLUSION: PDT and LEDT were prolonged at mid-CRT irradiation and further extended at early post-CRT. Additionally, N2c/N3 involvement, which typically necessitates bilateral neck irradiation fields and opioid use at mid-CRT, may constitute as risk factors for a delayed swallowing response.
Publisher	Springer Nature
Source Title	Supportive care in cancer
Volume (Issue)	33
Page	97
Date of Issued	2025-02-01
Language	English
Handle URL	https://hdl.handle.net/11094/100328
eISSN	14337339
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1007/s00520-024-09134-6
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCTERMS.bibliographicCitation	Supportive care in cancer. 2025, 33, p. 97
DC.title	Changes in swallowing response on patients undergoing chemoradiotherapy for head and neck cancer
DC.creator	Hashida, Nao
	Suzuki, Motoyuki
	Hosokawa, Kiyohito
	Takenaka, Yukinori
	Fukusumi, Takahito
	Takemoto, Norihiko
	Tanaka, Hidenori
	Kitamura, Koji
	Eguchi, Hirotaka
	Umatani, Masanori
	Kitayama, Itsuki
	Nozawa, Masayuki
	Kato, Chieri
	Okajima, Eri
	Inohara, Hidenori
DC.publisher	Springer Nature
DC.language' scheme='DCTERMS.RFC1766	English
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-02-01
DC.identifier	https://doi.org/10.1007/s00520-024-09134-6
DC.subject	Acute side effect
	Delayed swallowing initiation
	Swallowing response
DC.description	The version of record of this article, first published in Supportive care in cancer, is available online at Publisher’s website: https://doi.org/10.1007/s00520-024-09134-6.
DCTERMS.abstract	PURPOSE: Chemoradiotherapy (CRT) for head and neck cancer (HNC) often causes dysphagia. The risk of dysphagia increases during CRT tends to become more severe after finishing CRT, and persists for a few weeks thereafter. Thus, understanding the changes in swallowing physiology during and immediately after CRT is essential. This study aimed to clarify the changes in the swallowing response during and early after CRT and identify associated factors. METHODS: This retrospective study enrolled 107 patients with HNC who underwent CRT. We measured pharyngeal delay time (PDT) and laryngeal elevation delay time (LEDT) as indicators of the timing of the swallowing response at three time points: at CRT initiation (baseline), at 40-Gy irradiation during CRT (mid-CRT) and within 2 weeks following the completion of CRT (early post-CRT) as primary outcomes; and subgroup analyses based on clinical parameters, such as tumor sites, T stage, N stage, and opioid use at 40-Gy irradiation as secondary outcomes. RESULTS: Both PDT and LEDT were significantly prolonged between baseline and mid-CRT (PDT: p = 0.003, LEDT: p = 0.002) and between baseline and early post-CRT (PDT, p = 0.001; LEDT, p < 0.001). N2c/N3 and opioid use at 40-Gy irradiation showed prolonged PDT and LEDT at mid-CRT and early post-CRT. CONCLUSION: PDT and LEDT were prolonged at mid-CRT irradiation and further extended at early post-CRT. Additionally, N2c/N3 involvement, which typically necessitates bilateral neck irradiation fields and opioid use at mid-CRT, may constitute as risk factors for a delayed swallowing response.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	100328
citation_title	Changes in swallowing response on patients undergoing chemoradiotherapy for head and neck cancer
citation_author	Hashida, Nao
	Suzuki, Motoyuki
	Hosokawa, Kiyohito
	Takenaka, Yukinori
	Fukusumi, Takahito
	Takemoto, Norihiko
	Tanaka, Hidenori
	Kitamura, Koji
	Eguchi, Hirotaka
	Umatani, Masanori
	Kitayama, Itsuki
	Nozawa, Masayuki
	Kato, Chieri
	Okajima, Eri
	Inohara, Hidenori
citation_publisher	Springer Nature
citation_language	English
citation_date	2025-02-01
citation_journal_title	Supportive care in cancer
citation_volume	33
citation_firstpage	97
citation_doi	https://doi.org/10.1007/s00520-024-09134-6
citation_public_url	https://hdl.handle.net/11094/100328

Changes in swallowing response on patients undergoing chemoradiotherapy for head and neck cancer

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