Impact of switching from bisphosphonates to denosumab, teriparatide, or romosozumab in patients with postmenopausal osteoporosis: a case–control study

Yukishima, Toshitaka; Ebina, Kosuke; Etani, Yuki et al.

Osteoporosis International, 2025

Number of Access:1,061（2025-07-24 02:12 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/100329

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Title
Impact of switching from bisphosphonates to denosumab, teriparatide, or romosozumab in patients with postmenopausal osteoporosis: a case–control study
Creator
CreatorName
Yukishima, Toshitaka
NRID
1000070612076 1000070612076
ORCID
0000-0002-2426-1024 0000-0002-2426-1024
researchmap permalink
k-ebina k-ebina
Scopus Author ID
8415453300 8415453300
CreatorName
Ebina, Kosuke
NRID
1000060898930 1000060898930
ORCID
0000-0001-5741-5969 0000-0001-5741-5969
researchmap permalink
Yetani0302 Yetani0302
CreatorName
Etani, Yuki
NRID
1000050812294 1000050812294
researchmap permalink
takaakinoguchi takaakinoguchi
ORCID
0000-0001-9938-6780 0000-0001-9938-6780
CreatorName
Noguchi, Takaaki
CreatorName
Ohmura, Shin-ichiro
NRID
1000000283747 1000000283747
researchmap permalink
ken-nakata ken-nakata
Scopus Author ID
7402151308 7402151308
CreatorName
Nakata, Ken
NRID
1000030448435 1000030448435
ORCID
0000-0002-5107-8209 0000-0002-5107-8209
researchmap permalink
okadaseiji okadaseiji
Scopus Author ID
35079139100 35079139100
CreatorName
Okada, Seiji
CreatorName
Kobayakawa, Tomonori
Subject
Bone mineral density
Bisphosphonates
Denosumab
Teriparatide
Romosozumab
Description
The version of record of this article, first published in Osteoporosis International, is available online at Publisher’s website: https://doi.org/10.1007/s00198-025-07386-4.
Abstract
Summary: This case-control study investigated the impact of switching from bisphosphonates to denosumab, teriparatide, or romosozumab in postmenopausal osteoporosis. Romosozumab demonstrated the most significant improvements in bone mineral density, particularly in the lumbar spine and total hip, by reducing bone resorption and increasing bone formation markers. Purpose: To investigate the impact of switching from bisphosphonates (BP) to denosumab (DMAb), teriparatide (TPTD), or romosozumab (ROMO) in postmenopausal osteoporosis. Methods: This retrospective, case-controlled, multicenter study included 389 patients who switched from BP to DMAb, TPTD, or ROMO due to treatment inefficacy. Propensity score matching was used to align patient backgrounds, resulting in 45 patients per group. Baseline characteristics included a mean age of 73.8 years, prior BP treatment duration of 37.1 months, and bone mineral density (BMD) T-scores of -2.8 in the lumbar spine (LS), -2.5 in the total hip (TH), and -2.7 in femoral neck (FN). BMD and bone turnover markers were assessed over 12 months. Results: Following the switch from BP, the ROMO group demonstrated a dual effect of decreased bone resorption and increased bone formation markers. The TPTD group exhibited the highest increases in both markers, while the DMAb group suppressed both. After 12 months, the ROMO group demonstrated significantly greater BMD increases in the LS (11.4%) compared to the DMAb (6.3%; p < 0.001) and TPTD (5.9%; p < 0.001) groups. Additionally, the ROMO group showed greater increases in the TH (3.3%) than TPTD group (0.8%; p < 0.01). Only the ROMO group showed a significant BMD increase in the FN (2.0%; p < 0.01 from baseline). Conclusion: Significant BMD increases were observed in the LS for all groups, in the TH for the ROMO and DMAb groups, and in the FN for the ROMO group. ROMO showed the most substantial BMD improvements following BP therapy.
Publisher
Springer Science and Business Media LLC
Source Title
Osteoporosis International
Date of Issued
2025-01-16
Language
English
Handle URL
https://hdl.handle.net/11094/100329
PISSN
0937941X
eISSN
14332965
Relation.isIdenticalTo
DOI (Publisher Version)
https://doi.org/10.1007/s00198-025-07386-4
Access Rights
open access
CopyRight
This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
oaire:version
Version of Record
Category
学術雑誌論文 Journal Article