Hormonal mechanisms in the paraventricular nuclei associated with hyperalgesia in Parkinson's disease model rats

Yang, Shengsen; Usami, Nayuka; Lu, Shiou-Ling et al.

Biochemical and Biophysical Research Communications, 2025, 744, 151178

Number of Access:712（2025-08-15 06:45 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/100384

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Title
Hormonal mechanisms in the paraventricular nuclei associated with hyperalgesia in Parkinson's disease model rats
Creator
CreatorName
Yang, Shengsen
CreatorName
Usami, Nayuka
NRID
1000080830083 1000080830083
researchmap permalink
sally711017 sally711017
Scopus Author ID
39863311300 39863311300
CreatorName
Lu, Shiou-Ling
NRID
1000010964869 1000010964869
CreatorName
Oda, Wakana
NRID
1000010711012 1000010711012
researchmap permalink
maega maega
Scopus Author ID
36604752300 36604752300
CreatorName
Maegawa, Hiroharu
NRID
1000030218250 1000030218250
researchmap permalink
19580710 19580710
Scopus Author ID
24351577000 24351577000
CreatorName
Niwa, Hitoshi
NRID
1000020533110 1000020533110
researchmap permalink
chihokudo chihokudo
Scopus Author ID
6701693347 6701693347
CreatorName
Kudo, Chiho
Description
Yang S., Usami N., Lu S.L., et al. Hormonal mechanisms in the paraventricular nuclei associated with hyperalgesia in Parkinson's disease model rats. Biochemical and Biophysical Research Communications 744, 151178 (2025); https://doi.org/10.1016/j.bbrc.2024.151178.
Abstract
Pain is a major non-motor symptom of Parkinson's disease (PD). The relationship between hyperalgesia and neuropeptides originating from paraventricular nucleus (PVN) in 6-hydroxydopamine (6-OHDA) rats has already been investigated for oxytocin (OXT), but not yet for arginine vasopressin (AVP) and corticotropin-releasing hormone (CRH). The present study aimed to investigate the alterations in these neuropeptides following nociceptive stimulation in PD model rats and to examine the mechanisms of hyperalgesia. Dopaminergic nigrostriatal lesions were induced by injecting 6-OHDA into the medial forebrain bundle. Subcutaneous formalin injection into the vibrissa pad was performed in rats as a nociceptive stimulus in the orofacial region. Dopamine depletion's effect on nociception was assessed by counting the p-ERK-immunoreactive (-IR) cells in the trigeminal spinal subnucleus caudalis (Vc). The PD model rats induced by 6-OHDA injection (6-OHDA rats) showed a significantly higher number of p-ERK-IR cells in the Vc than the sham rats, confirming hyperalgesia in 6-OHDA rats. Then, we investigated the immunohistochemical responses to OXT, AVP, and CRH cells in the PVN and examined the changes in blood levels of these neuropeptides. As a result, formalin injection increased neuronal activity and blood levels of OXT and CRH in sham rats, but these were suppressed in the 6-OHDA rats. Contrarily, neuronal activity and blood level of AVP were unaffected by nociceptive stimuli and were significantly lower in 6-OHDA rats than in sham rats. Our findings suggest that OXT and CRH suppression is linked to hyperalgesia in PD, whereas AVP does not directly influence the observed hyperalgesia.
Publisher
Elsevier B.V.
Source Title
Biochemical and Biophysical Research Communications
Volume (Issue)
744
Page
151178
Date of Issued
2025-01-01
Language
English
Handle URL
https://hdl.handle.net/11094/100384
PISSN
0006291X
eISSN
10902104
Relation.isIdenticalTo
DOI (Publisher Version)
https://doi.org/10.1016/j.bbrc.2024.151178
Access Rights
open access
CopyRight
This article is licensed under a Creative Commons Attribution 4.0 International License.
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Category
学術雑誌論文 Journal Article