Relation of squamous differentiation in endometrioid carcinoma with MELF pattern to a high ratio of lymph node metastasis

Tahara, Shinichiro; Sato, Kazuaki; Kido, Kansuke et al.

Pathology - Research and Practice, 2025, 266, 155804

Number of Access:652（2025-10-27 22:07 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/100393

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Title
Relation of squamous differentiation in endometrioid carcinoma with MELF pattern to a high ratio of lymph node metastasis
Creator
NRID
1000020792584 1000020792584
ORCID
0000-0001-6134-3275 0000-0001-6134-3275
researchmap permalink
s_tahara s_tahara
Scopus Author ID
57189030096 57189030096
CreatorName
Tahara, Shinichiro
CreatorName
Sato, Kazuaki
researchmap permalink
kansukekido kansukekido
CreatorName
Kido, Kansuke
NRID
1000010283772 1000010283772
ORCID
0000-0001-8490-3650 0000-0001-8490-3650
researchmap permalink
read0046454 read0046454
Scopus Author ID
7003914326 7003914326
CreatorName
Morii, Eiichi
Description
Tahara Shinichiro, Sato Kazuaki, Kido Kansuke, et al. Relation of squamous differentiation in endometrioid carcinoma with MELF pattern to a high ratio of lymph node metastasis. Pathology - Research and Practice 266, 155804 (); https://doi.org/10.1016/j.prp.2024.155804.
Abstract
One of the known histological patterns of endometrioid carcinoma (EC) in uterine corpus cancer is MELF (microcystic, elongated, and fragmented). MELF is associated with lymphovascular invasion and lymph node metastasis. Besides MELF, it is also known that squamous differentiation (SD) often occurs in EC. SD is known to be no significant difference in the frequency of lymph node metastasis in EC. However, there have been no previous reports on the association between MELF and SD. In this research, we investigated the presence of SD in MELF using an antibody to CK5. We examined 28 cases of EC with MELF pattern, in which 15 cases showed SD. Moreover, the relation of lymph node metastasis to SD was examined. Lymph node dissection was performed in 27 out of 28 cases. Among them, 12 cases showed lymph node metastasis. The ratio of lymph node metastasis was significantly higher in EC with SD (64.3 %, 9 in 14 cases) than EC without SD (23.1 %, 3 in 13 cases). In this study, we first showed the association between SD and MELF and that MELF with SD is associated with a high ratio of lymph node metastasis. It is clinically relevant to recognize that MELF with SD is aggressive with a high ratio of lymph node metastasis.
Publisher
Elsevier BV
Source Title
Pathology - Research and Practice
Volume (Issue)
266
Page
155804
Date of Issued
2025-02-01
Language
English
Handle URL
https://hdl.handle.net/11094/100393
PISSN
03440338
Relation.isIdenticalTo
DOI (Publisher Version)
https://doi.org/10.1016/j.prp.2024.155804
Access Rights
open access
CopyRight
This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
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Category
学術雑誌論文 Journal Article