Spatial transcriptome analysis of lung squamous cell carcinoma arising from interstitial pneumonia provides insights into tumor heterogeneity

Ukon, Koto; Nojima, Satoshi; Motooka, Daisuke; Takashima, Tsuyoshi; Kohara, Masaharu; Kiyokawa, Hiroki; Kimura, Kenji; Fukui, Eriko; Tahara, Shinichiro; Kido, Kansuke; Matsui, Takahiro; Shintani, Yasushi; Okuzaki, Daisuke; Morii, Eiichi

doi:https://doi.org/10.1016/j.prp.2024.155805

Spatial transcriptome analysis of lung squamous cell carcinoma arising from interstitial pneumonia provides insights into tumor heterogeneity

Ukon, Koto; Nojima, Satoshi; Motooka, Daisuke et al.

Pathology - Research and Practice, 2025, 266, 155805

Number of Access:2,135（2025-07-18 12:29 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/100394

Link to primary information

File	Format	Terms of use	Size	Views	Date.Available	Description	information
Pathology-ResearchandPractice_266_155805	pdf	None	9.53 MB	36	2025.02.20

Creative Commons : Attribution - NonCommercial

Item Information

Output File Export EndNote Basic Export Mendeley

Title	Spatial transcriptome analysis of lung squamous cell carcinoma arising from interstitial pneumonia provides insights into tumor heterogeneity
Creator	CreatorName Ukon, Koto
	NRID 1000040528791 1000040528791 ORCID 0000-0002-5124-0026 0000-0002-5124-0026 researchmap permalink snojima snojima Scopus Author ID 16224082000 16224082000 CreatorName Nojima, Satoshi
	NRID 1000010636830 1000010636830 researchmap permalink daisukem daisukem Scopus Author ID 35315737900 35315737900 CreatorName Motooka, Daisuke
	CreatorName Takashima, Tsuyoshi
	ORCID 0009-0006-7636-5833 0009-0006-7636-5833 CreatorName Kohara, Masaharu
	NRID 1000090973785 1000090973785 researchmap permalink hiroki_kiyokawa hiroki_kiyokawa CreatorName Kiyokawa, Hiroki
	NRID 1000050795325 1000050795325 researchmap permalink kenkimurathoracic kenkimurathoracic CreatorName Kimura, Kenji
	NRID 1000090814591 1000090814591 researchmap permalink ef90814591 ef90814591 Scopus Author ID 57205560883 57205560883 CreatorName Fukui, Eriko
	NRID 1000020792584 1000020792584 ORCID 0000-0001-6134-3275 0000-0001-6134-3275 researchmap permalink s_tahara s_tahara Scopus Author ID 57189030096 57189030096 CreatorName Tahara, Shinichiro
	researchmap permalink kansukekido kansukekido CreatorName Kido, Kansuke
	NRID 1000050747037 1000050747037 ORCID 0000-0002-6753-1688 0000-0002-6753-1688 researchmap permalink takahiromatsui takahiromatsui Scopus Author ID 35176152500 35176152500 CreatorName Matsui, Takahiro
	NRID 1000090572983 1000090572983 researchmap permalink shintani6384 shintani6384 Scopus Author ID 7103142734 7103142734 CreatorName Shintani, Yasushi
	NRID 1000000346131 1000000346131 ORCID 0000-0002-4552-783X 0000-0002-4552-783X researchmap permalink read0092307 read0092307 Scopus Author ID 6506703054 6506703054 CreatorName Okuzaki, Daisuke
	NRID 1000010283772 1000010283772 ORCID 0000-0001-8490-3650 0000-0001-8490-3650 researchmap permalink read0046454 read0046454 Scopus Author ID 7003914326 7003914326 CreatorName Morii, Eiichi
Description	Ukon Koto, Nojima Satoshi, Motooka Daisuke, et al. Spatial transcriptome analysis of lung squamous cell carcinoma arising from interstitial pneumonia provides insights into tumor heterogeneity. Pathology - Research and Practice 266, 155805 (); https://doi.org/10.1016/j.prp.2024.155805.
Abstract	Interstitial pneumonia (IP) is a refractory disease that causes severe inflammation and fibrosis in the interstitium of the lungs, often resulting in the development of lung cancer (LC) during treatment. Previous studies have demonstrated that the prognosis of LC complicated by IP is inferior to that of LC without IP. It is therefore of the utmost importance to gain a deeper understanding of the heterogeneity of such tumors. In the present study, we conducted spatial transcriptome analysis of squamous cell carcinoma arising from IP. The results suggested involvement of the glucocorticoid receptor pathway in treatment resistance. Immunostaining of squamous cell carcinoma specimens from patients with IP demonstrated that the tumors expressed NR3C1 to varying degrees. Furthermore, higher NR3C1 expression levels were associated with a significantly increased risk of recurrence. Our results point to a novel subtype of lung squamous cell carcinoma. Further analysis of the molecular mechanisms associated with this subtype may facilitate the development of novel diagnostic criteria and therapeutic approaches.
Publisher	Elsevier BV
Source Title	Pathology - Research and Practice
Volume (Issue)	266
Page	155805
Date of Issued	2025-02-01
Language	English
Handle URL	https://hdl.handle.net/11094/100394
PISSN	03440338
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1016/j.prp.2024.155805
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCTERMS.bibliographicCitation	Pathology - Research and Practice. 2025, 266, p. 155805
DC.title	Spatial transcriptome analysis of lung squamous cell carcinoma arising from interstitial pneumonia provides insights into tumor heterogeneity
DC.creator	Ukon, Koto
	Nojima, Satoshi
	Motooka, Daisuke
	Takashima, Tsuyoshi
	Kohara, Masaharu
	Kiyokawa, Hiroki
	Kimura, Kenji
	Fukui, Eriko
	Tahara, Shinichiro
	Kido, Kansuke
	Matsui, Takahiro
	Shintani, Yasushi
	Okuzaki, Daisuke
	Morii, Eiichi
DC.publisher	Elsevier BV
DC.language' scheme='DCTERMS.RFC1766	English
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-02-01
DC.identifier	https://doi.org/10.1016/j.prp.2024.155805
DC.description	Ukon Koto, Nojima Satoshi, Motooka Daisuke, et al. Spatial transcriptome analysis of lung squamous cell carcinoma arising from interstitial pneumonia provides insights into tumor heterogeneity. Pathology - Research and Practice 266, 155805 (); https://doi.org/10.1016/j.prp.2024.155805.
DCTERMS.abstract	Interstitial pneumonia (IP) is a refractory disease that causes severe inflammation and fibrosis in the interstitium of the lungs, often resulting in the development of lung cancer (LC) during treatment. Previous studies have demonstrated that the prognosis of LC complicated by IP is inferior to that of LC without IP. It is therefore of the utmost importance to gain a deeper understanding of the heterogeneity of such tumors. In the present study, we conducted spatial transcriptome analysis of squamous cell carcinoma arising from IP. The results suggested involvement of the glucocorticoid receptor pathway in treatment resistance. Immunostaining of squamous cell carcinoma specimens from patients with IP demonstrated that the tumors expressed NR3C1 to varying degrees. Furthermore, higher NR3C1 expression levels were associated with a significantly increased risk of recurrence. Our results point to a novel subtype of lung squamous cell carcinoma. Further analysis of the molecular mechanisms associated with this subtype may facilitate the development of novel diagnostic criteria and therapeutic approaches.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
DC.format	100394
citation_title	Spatial transcriptome analysis of lung squamous cell carcinoma arising from interstitial pneumonia provides insights into tumor heterogeneity
citation_author	Ukon, Koto
	Nojima, Satoshi
	Motooka, Daisuke
	Takashima, Tsuyoshi
	Kohara, Masaharu
	Kiyokawa, Hiroki
	Kimura, Kenji
	Fukui, Eriko
	Tahara, Shinichiro
	Kido, Kansuke
	Matsui, Takahiro
	Shintani, Yasushi
	Okuzaki, Daisuke
	Morii, Eiichi
citation_publisher	Elsevier BV
citation_language	English
citation_date	2025-02-01
citation_journal_title	Pathology - Research and Practice
citation_volume	266
citation_firstpage	155805
citation_doi	https://doi.org/10.1016/j.prp.2024.155805
citation_public_url	https://hdl.handle.net/11094/100394

Spatial transcriptome analysis of lung squamous cell carcinoma arising from interstitial pneumonia provides insights into tumor heterogeneity

Link to primary information

Item Information

Show details