Association between choroid plexus volume and cognitive function in community-dwelling older adults without dementia: a population-based cross-sectional analysis

Hidaka, Yosuke; Hashimoto, Mamoru; Suehiro, Takashi; Fukuhara, Ryuji; Ishikawa, Tomohisa; Tsunoda, Naoko; Koyama, Asuka; Honda, Kazuki; Miyagawa, Yusuke; Yoshiura, Kazuhiro; Yuuki, Seiji; Kajitani, Naoto; Boku, Shuken; Ishii, Kazunari; Ikeda, Manabu; Takebayashi, Minoru

doi:https://doi.org/10.1186/S12987-024-00601-0

Association between choroid plexus volume and cognitive function in community-dwelling older adults without dementia: a population-based cross-sectional analysis

Hidaka, Yosuke; Hashimoto, Mamoru; Suehiro, Takashi et al.

Fluids and Barriers of the CNS, 2024, 21, 101

Number of Access:1,624（2025-08-15 01:10 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/100422

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Title	Association between choroid plexus volume and cognitive function in community-dwelling older adults without dementia: a population-based cross-sectional analysis
Creator	NRID 1000020973895 1000020973895 researchmap permalink yosukehidaka yosukehidaka Scopus Author ID 57206726738 57206726738 CreatorName Hidaka, Yosuke
	NRID 1000020452881 1000020452881 CreatorName Hashimoto, Mamoru
	NRID 1000030866611 1000030866611 researchmap permalink suehiro-takashi suehiro-takashi Scopus Author ID 57190874433 57190874433 CreatorName Suehiro, Takashi
	NRID 1000060346682 1000060346682 CreatorName Fukuhara, Ryuji
	NRID 1000060419512 1000060419512 CreatorName Ishikawa, Tomohisa
	CreatorName Tsunoda, Naoko
	NRID 1000050710670 1000050710670 CreatorName Koyama, Asuka
	CreatorName Honda, Kazuki
	CreatorName Miyagawa, Yusuke
	NRID 1000030748067 1000030748067 CreatorName Yoshiura, Kazuhiro
	CreatorName Yuuki, Seiji
	NRID 1000060755742 1000060755742 CreatorName Kajitani, Naoto
	NRID 1000060455665 1000060455665 CreatorName Boku, Shuken
	NRID 1000050534103 1000050534103 CreatorName Ishii, Kazunari
	NRID 1000060284395 1000060284395 researchmap permalink manabu_ikeda manabu_ikeda Scopus Author ID 7404692889 7404692889 CreatorName Ikeda, Manabu
	NRID 1000060304440 1000060304440 CreatorName Takebayashi, Minoru
Subject	Cerebrospinal fluid
	Choroid plexus
	Cognitive impairment
Description	Hidaka Y., Hashimoto M., Suehiro T., et al. Association between choroid plexus volume and cognitive function in community-dwelling older adults without dementia: a population-based cross-sectional analysis. Fluids and Barriers of the CNS 21, 101 (2024); https://doi.org/10.1186/S12987-024-00601-0.
Abstract	Background: An increase in choroid plexus (CP) volume may be associated with cognitive decline in older individuals without dementia. In this study, we aimed to clarify whether CP volume can serve as an imaging marker of cognitive decline, determine how strongly CP volume is associated with cognitive decline, and explore factors associated with CP volume in older adults. Methods: We measured CP volume, brain parenchyma, and cerebrospinal fluid (CSF) spaces associated with disproportionately enlarged subarachnoid space hydrocephalus (DESH), an imaging feature of normal-pressure hydrocephalus, in community-dwelling older adults aged ≥ 65 years without dementia. Results: In 1,370 participants, lower Mini-Mental State Examination (MMSE) scores were significantly associated with higher CP volume, even after adjusting for DESH-related CSF space and brain parenchymal volume. CP volume was more strongly associated with MMSE scores than DESH-related CSF space and brain parenchymal volume. History of smoking, white matter hyperintensity, enlarged perivascular spaces, age, body mass index, and diabetes mellitus were also associated with increased CP volume. Conclusions: CP volume may be a highly sensitive imaging marker of cognitive decline in community-dwelling older adults without dementia, as it is linked to cognitive decline independently of brain parenchyma and CSF volumes. Our findings emphasize the importance of investigating CP volume increase to maintain cognitive function in older individuals. Accordingly, further longitudinal studies are required.
Publisher	BioMed Central Ltd
Source Title	Fluids and Barriers of the CNS
Volume (Issue)	21
Page	101
Date of Issued	2024-12-18
Language	English
Handle URL	https://hdl.handle.net/11094/100422
eISSN	20458118
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1186/S12987-024-00601-0
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCTERMS.bibliographicCitation	Fluids and Barriers of the CNS. 2024, 21, p. 101
DC.title	Association between choroid plexus volume and cognitive function in community-dwelling older adults without dementia: a population-based cross-sectional analysis
DC.creator	Hidaka, Yosuke
	Hashimoto, Mamoru
	Suehiro, Takashi
	Fukuhara, Ryuji
	Ishikawa, Tomohisa
	Tsunoda, Naoko
	Koyama, Asuka
	Honda, Kazuki
	Miyagawa, Yusuke
	Yoshiura, Kazuhiro
	Yuuki, Seiji
	Kajitani, Naoto
	Boku, Shuken
	Ishii, Kazunari
	Ikeda, Manabu
	Takebayashi, Minoru
DC.publisher	BioMed Central Ltd
DC.language' scheme='DCTERMS.RFC1766	English
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-12-18
DC.identifier	https://doi.org/10.1186/S12987-024-00601-0
DC.subject	Cerebrospinal fluid
	Choroid plexus
	Cognitive impairment
DC.description	Hidaka Y., Hashimoto M., Suehiro T., et al. Association between choroid plexus volume and cognitive function in community-dwelling older adults without dementia: a population-based cross-sectional analysis. Fluids and Barriers of the CNS 21, 101 (2024); https://doi.org/10.1186/S12987-024-00601-0.
DCTERMS.abstract	Background: An increase in choroid plexus (CP) volume may be associated with cognitive decline in older individuals without dementia. In this study, we aimed to clarify whether CP volume can serve as an imaging marker of cognitive decline, determine how strongly CP volume is associated with cognitive decline, and explore factors associated with CP volume in older adults. Methods: We measured CP volume, brain parenchyma, and cerebrospinal fluid (CSF) spaces associated with disproportionately enlarged subarachnoid space hydrocephalus (DESH), an imaging feature of normal-pressure hydrocephalus, in community-dwelling older adults aged ≥ 65 years without dementia. Results: In 1,370 participants, lower Mini-Mental State Examination (MMSE) scores were significantly associated with higher CP volume, even after adjusting for DESH-related CSF space and brain parenchymal volume. CP volume was more strongly associated with MMSE scores than DESH-related CSF space and brain parenchymal volume. History of smoking, white matter hyperintensity, enlarged perivascular spaces, age, body mass index, and diabetes mellitus were also associated with increased CP volume. Conclusions: CP volume may be a highly sensitive imaging marker of cognitive decline in community-dwelling older adults without dementia, as it is linked to cognitive decline independently of brain parenchyma and CSF volumes. Our findings emphasize the importance of investigating CP volume increase to maintain cognitive function in older individuals. Accordingly, further longitudinal studies are required.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
DC.format	100422
citation_title	Association between choroid plexus volume and cognitive function in community-dwelling older adults without dementia: a population-based cross-sectional analysis
citation_author	Hidaka, Yosuke
	Hashimoto, Mamoru
	Suehiro, Takashi
	Fukuhara, Ryuji
	Ishikawa, Tomohisa
	Tsunoda, Naoko
	Koyama, Asuka
	Honda, Kazuki
	Miyagawa, Yusuke
	Yoshiura, Kazuhiro
	Yuuki, Seiji
	Kajitani, Naoto
	Boku, Shuken
	Ishii, Kazunari
	Ikeda, Manabu
	Takebayashi, Minoru
citation_publisher	BioMed Central Ltd
citation_language	English
citation_date	2024-12-18
citation_journal_title	Fluids and Barriers of the CNS
citation_volume	21
citation_firstpage	101
citation_doi	https://doi.org/10.1186/S12987-024-00601-0
citation_public_url	https://hdl.handle.net/11094/100422

Association between choroid plexus volume and cognitive function in community-dwelling older adults without dementia: a population-based cross-sectional analysis

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