Association between oxidative stress and postoperative delirium in joint replacement using diacron-reactive oxygen metabolites and biological antioxidant potential tests

Yuba, Tomoo; Koyama, Yoshihisa; Takahashi, Ayako; Fujino, Yuji; Shimada, Shoichi

doi:https://doi.org/10.1038/s41598-024-80739-x

Association between oxidative stress and postoperative delirium in joint replacement using diacron-reactive oxygen metabolites and biological antioxidant potential tests

Yuba, Tomoo; Koyama, Yoshihisa; Takahashi, Ayako et al.

Scientific Reports, 2024, 14, 29854

Number of Access:739（2025-08-16 03:17 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/100428

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Title	Association between oxidative stress and postoperative delirium in joint replacement using diacron-reactive oxygen metabolites and biological antioxidant potential tests
Creator	CreatorName Yuba, Tomoo
	NRID 1000040397667 1000040397667 researchmap permalink koyamayoshihisa koyamayoshihisa Scopus Author ID 49761644100 49761644100 CreatorName Koyama, Yoshihisa
	NRID 1000070444544 1000070444544 researchmap permalink takahashi_a takahashi_a Scopus Author ID 56720024400 56720024400 CreatorName Takahashi, Ayako
	NRID 1000050252672 1000050252672 researchmap permalink y_fujino y_fujino Scopus Author ID 19134445600 19134445600 CreatorName Fujino, Yuji
	NRID 1000020216063 1000020216063 ORCID 0000-0001-5369-1069 0000-0001-5369-1069 researchmap permalink 556shimada 556shimada Scopus Author ID 35452177800 35452177800 CreatorName Shimada, Shoichi
Subject	Biological antioxidant potential test
	Diacron-reactive oxygen metabolites test
	Joint replacement surgery
	Oxidative stress
	Postoperative delirium
Description	Yuba T., Koyama Y., Takahashi A., et al. Association between oxidative stress and postoperative delirium in joint replacement using diacron-reactive oxygen metabolites and biological antioxidant potential tests. Scientific Reports 14, 29854 (2024); https://doi.org/10.1038/s41598-024-80739-x.
Abstract	Postoperative delirium (POD) is a significant complication of surgery that most severely affects older adults and patients with cognitive impairment. This study investigated the relationship between POD and oxidative stress, hypothesizing that increased oxidative stress, measured using diacron-reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP) tests, is associated with the incidence of POD. This prospective cohort study, involving female patients who underwent unilateral or bilateral joint replacement, was conducted at the Osaka University Graduate School of Medicine from June 2022 to July 2023. Blood samples were collected preoperatively and postoperatively to measure oxidative stress markers using the REDOXLIBRA system. The primary endpoint was the association between changes in oxidative stress markers and the occurrence of POD as diagnosed using the Confusion Assessment Method for the Intensive Care Unit and Richmond Agitation–Sedation Scale. Of the 144 patients screened, 60 were eligible, of which 5 developed POD (8.3%). Analysis of oxidative stress markers revealed no significant changes between preoperative and postoperative values of d-ROMs (mean increase + 6.3 ± 54.2 U CARR) and BAP (mean decrease − 37.4 ± 322.9 µM) tests, or BAP/d-ROMs ratio (mean decrease − 0.4 ± 1.7). Further, no significant differences were observed in oxidative stress markers between patients who underwent unilateral and bilateral procedures. However, patients with POD exhibited a significantly higher increase in d-ROMs than those without complications (p = 0.015), whereas changes in BAP and BAP/d-ROM ratios were not statistically significant. Although general oxidative stress markers do not significantly change postoperatively, increased d-ROM levels are associated with POD occurrence, indicating that oxidative stress could be a contributing factor to its development. This study underscores the need for further research into specific oxidative markers that may predict POD and guide the development of targeted interventions to prevent this debilitating condition.
Publisher	Nature Research
Source Title	Scientific Reports
Volume (Issue)	14
Page	29854
Date of Issued	2024-12-02
Language	English
Handle URL	https://hdl.handle.net/11094/100428
eISSN	20452322
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1038/s41598-024-80739-x
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCTERMS.bibliographicCitation	Scientific Reports. 2024, 14, p. 29854
DC.title	Association between oxidative stress and postoperative delirium in joint replacement using diacron-reactive oxygen metabolites and biological antioxidant potential tests
DC.creator	Yuba, Tomoo
	Koyama, Yoshihisa
	Takahashi, Ayako
	Fujino, Yuji
	Shimada, Shoichi
DC.publisher	Nature Research
DC.language' scheme='DCTERMS.RFC1766	English
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-12-02
DC.identifier	https://doi.org/10.1038/s41598-024-80739-x
DC.subject	Biological antioxidant potential test
	Diacron-reactive oxygen metabolites test
	Joint replacement surgery
	Oxidative stress
	Postoperative delirium
DC.description	Yuba T., Koyama Y., Takahashi A., et al. Association between oxidative stress and postoperative delirium in joint replacement using diacron-reactive oxygen metabolites and biological antioxidant potential tests. Scientific Reports 14, 29854 (2024); https://doi.org/10.1038/s41598-024-80739-x.
DCTERMS.abstract	Postoperative delirium (POD) is a significant complication of surgery that most severely affects older adults and patients with cognitive impairment. This study investigated the relationship between POD and oxidative stress, hypothesizing that increased oxidative stress, measured using diacron-reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP) tests, is associated with the incidence of POD. This prospective cohort study, involving female patients who underwent unilateral or bilateral joint replacement, was conducted at the Osaka University Graduate School of Medicine from June 2022 to July 2023. Blood samples were collected preoperatively and postoperatively to measure oxidative stress markers using the REDOXLIBRA system. The primary endpoint was the association between changes in oxidative stress markers and the occurrence of POD as diagnosed using the Confusion Assessment Method for the Intensive Care Unit and Richmond Agitation–Sedation Scale. Of the 144 patients screened, 60 were eligible, of which 5 developed POD (8.3%). Analysis of oxidative stress markers revealed no significant changes between preoperative and postoperative values of d-ROMs (mean increase + 6.3 ± 54.2 U CARR) and BAP (mean decrease − 37.4 ± 322.9 µM) tests, or BAP/d-ROMs ratio (mean decrease − 0.4 ± 1.7). Further, no significant differences were observed in oxidative stress markers between patients who underwent unilateral and bilateral procedures. However, patients with POD exhibited a significantly higher increase in d-ROMs than those without complications (p = 0.015), whereas changes in BAP and BAP/d-ROM ratios were not statistically significant. Although general oxidative stress markers do not significantly change postoperatively, increased d-ROM levels are associated with POD occurrence, indicating that oxidative stress could be a contributing factor to its development. This study underscores the need for further research into specific oxidative markers that may predict POD and guide the development of targeted interventions to prevent this debilitating condition.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	100428
citation_title	Association between oxidative stress and postoperative delirium in joint replacement using diacron-reactive oxygen metabolites and biological antioxidant potential tests
citation_author	Yuba, Tomoo
	Koyama, Yoshihisa
	Takahashi, Ayako
	Fujino, Yuji
	Shimada, Shoichi
citation_publisher	Nature Research
citation_language	English
citation_date	2024-12-02
citation_journal_title	Scientific Reports
citation_volume	14
citation_firstpage	29854
citation_doi	https://doi.org/10.1038/s41598-024-80739-x
citation_public_url	https://hdl.handle.net/11094/100428

Association between oxidative stress and postoperative delirium in joint replacement using diacron-reactive oxygen metabolites and biological antioxidant potential tests

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