Transmembrane voltage-gated nanopores controlled by electrically tunable in-pore chemistry

Tsutsui, Makusu; Hsu, Wei-Lun; Hsu, Chien; Garoli, Denis; Weng, Shukun; Daiguji, Hirofumi; Kawai, Tomoji

doi:https://doi.org/10.1038/s41467-025-56052-0

Transmembrane voltage-gated nanopores controlled by electrically tunable in-pore chemistry

Tsutsui, Makusu; Hsu, Wei-Lun; Hsu, Chien et al.

Nature Communications, 2025, 16, 1089

Number of Access:517（2025-09-04 09:48 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/100438

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Title	Transmembrane voltage-gated nanopores controlled by electrically tunable in-pore chemistry
Creator	NRID 1000050546596 1000050546596 ORCID 0000-0002-4552-1163 0000-0002-4552-1163 researchmap permalink makusu makusu Scopus Author ID 8978905800 8978905800 CreatorName Tsutsui, Makusu
	NRID 1000050771549 1000050771549 CreatorName Hsu, Wei-Lun
	CreatorName Hsu, Chien
	CreatorName Garoli, Denis
	CreatorName Weng, Shukun
	NRID 1000010302754 1000010302754 CreatorName Daiguji, Hirofumi
	NRID 1000020092546 1000020092546 researchmap permalink read0014173 read0014173 CreatorName Kawai, Tomoji
Description	Tsutsui M., Hsu W.L., Hsu C., et al. Transmembrane voltage-gated nanopores controlled by electrically tunable in-pore chemistry. Nature Communications 16, 1089 (2025); https://doi.org/10.1038/s41467-025-56052-0.
Abstract	Gating is a fundamental process in ion channels configured to open and close in response to specific stimuli such as voltage across cell membranes thereby enabling the excitability of neurons. Here we report on voltage-gated solid-state nanopores by electrically tunable chemical reactions. We demonstrate repetitive precipitation and dissolution of metal phosphates in a pore through manipulations of cation flow by transmembrane voltage. Under negative voltages, precipitates grow to reduce ionic current by occluding the nanopore, while inverting the voltage polarity dissolves the phosphate compounds reopening the pore to ionic flux. Reversible actuation of these physicochemical processes creates a nanofluidic diode of rectification ratio exceeding 40000. The dynamic nature of the in-pore reactions also facilitates a memristor of sub-nanowatt power consumption. Leveraging chemical degrees of freedom, the present method may be useful for creating iontronic circuits of tunable characteristics toward neuromorphic systems.
Publisher	Nature Research
Source Title	Nature Communications
Volume (Issue)	16
Page	1089
Date of Issued	2025-02-05
Language	English
Handle URL	https://hdl.handle.net/11094/100438
eISSN	20411723
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1038/s41467-025-56052-0
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCTERMS.bibliographicCitation	Nature Communications. 2025, 16, p. 1089
DC.title	Transmembrane voltage-gated nanopores controlled by electrically tunable in-pore chemistry
DC.creator	Tsutsui, Makusu
	Hsu, Wei-Lun
	Hsu, Chien
	Garoli, Denis
	Weng, Shukun
	Daiguji, Hirofumi
	Kawai, Tomoji
DC.publisher	Nature Research
DC.language' scheme='DCTERMS.RFC1766	English
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-02-05
DC.identifier	https://doi.org/10.1038/s41467-025-56052-0
DC.description	Tsutsui M., Hsu W.L., Hsu C., et al. Transmembrane voltage-gated nanopores controlled by electrically tunable in-pore chemistry. Nature Communications 16, 1089 (2025); https://doi.org/10.1038/s41467-025-56052-0.
DCTERMS.abstract	Gating is a fundamental process in ion channels configured to open and close in response to specific stimuli such as voltage across cell membranes thereby enabling the excitability of neurons. Here we report on voltage-gated solid-state nanopores by electrically tunable chemical reactions. We demonstrate repetitive precipitation and dissolution of metal phosphates in a pore through manipulations of cation flow by transmembrane voltage. Under negative voltages, precipitates grow to reduce ionic current by occluding the nanopore, while inverting the voltage polarity dissolves the phosphate compounds reopening the pore to ionic flux. Reversible actuation of these physicochemical processes creates a nanofluidic diode of rectification ratio exceeding 40000. The dynamic nature of the in-pore reactions also facilitates a memristor of sub-nanowatt power consumption. Leveraging chemical degrees of freedom, the present method may be useful for creating iontronic circuits of tunable characteristics toward neuromorphic systems.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
DC.format	100438
citation_title	Transmembrane voltage-gated nanopores controlled by electrically tunable in-pore chemistry
citation_author	Tsutsui, Makusu
	Hsu, Wei-Lun
	Hsu, Chien
	Garoli, Denis
	Weng, Shukun
	Daiguji, Hirofumi
	Kawai, Tomoji
citation_publisher	Nature Research
citation_language	English
citation_date	2025-02-05
citation_journal_title	Nature Communications
citation_volume	16
citation_firstpage	1089
citation_doi	https://doi.org/10.1038/s41467-025-56052-0
citation_public_url	https://hdl.handle.net/11094/100438

Transmembrane voltage-gated nanopores controlled by electrically tunable in-pore chemistry

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