Serial Change and Clinical Impact of Irregular Protrusion in Lesions With Chronic Coronary Syndrome

Okamoto, Naotaka; Mizote, Isamu; Ishihara, Takayuki; Nakamura, Daisuke; Shiraki, Tatsusya; Itaya, Naoki; Tsujimura, Takuya; Takahara, Mitsuyoshi; Hikosou, Shungo; Mano, Toshiaki; Ueno, Takahumi; Nishino, Masami; Nanto, Shinsuke; Sakata, Yasushi

doi:https://doi.org/10.1002/ccd.31430

Serial Change and Clinical Impact of Irregular Protrusion in Lesions With Chronic Coronary Syndrome

Okamoto, Naotaka; Mizote, Isamu; Ishihara, Takayuki et al.

Catheterization and Cardiovascular Interventions, 2025

Number of Access:95（2025-05-24 16:41 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/100545

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Title	Serial Change and Clinical Impact of Irregular Protrusion in Lesions With Chronic Coronary Syndrome
Creator	CreatorName Okamoto, Naotaka
	NRID 1000010584609 1000010584609 researchmap permalink mizoteisamu mizoteisamu Scopus Author ID 8266113500 8266113500 CreatorName Mizote, Isamu
	CreatorName Ishihara, Takayuki
	NRID 1000030869970 1000030869970 researchmap permalink daifromn0525 daifromn0525 CreatorName Nakamura, Daisuke
	NRID 1000060784056 1000060784056 CreatorName Shiraki, Tatsusya
	CreatorName Itaya, Naoki
	CreatorName Tsujimura, Takuya
	NRID 1000000751067 1000000751067 researchmap permalink takahara-mitsuyoshi takahara-mitsuyoshi Scopus Author ID 35933605700 35933605700 CreatorName Takahara, Mitsuyoshi
	NRID 1000030423164 1000030423164 researchmap permalink hikoso_osakauniv hikoso_osakauniv CreatorName Hikosou, Shungo
	CreatorName Mano, Toshiaki
	CreatorName Ueno, Takahumi
	CreatorName Nishino, Masami
	CreatorName Nanto, Shinsuke
	NRID 1000000397671 1000000397671 ORCID 0000-0002-5618-4721 0000-0002-5618-4721 researchmap permalink C4589 C4589 Scopus Author ID 35395964700 35395964700 CreatorName Sakata, Yasushi
Subject	chronic coronary syndrome
	irregular protrusion
	optical coherence tomography
Description	Okamoto N., Mizote I., Ishihara T., et al. Serial Change and Clinical Impact of Irregular Protrusion in Lesions With Chronic Coronary Syndrome. Catheterization and Cardiovascular Interventions, (2025); https://doi.org/10.1002/ccd.31430.
Abstract	Background: The changes over time and effects on long-term clinical outcomes beyond 1 year of irregular protrusion (IP) in chronic coronary syndrome (CCS) remains unclear. Aims: This study aimed to assess the time-dependent change and long-term clinical impact of IP in CCS lesions. Methods: This study was a post hoc analysis of COLLABORATION study, which was a multicenter, prospective, observational study conducted from July 2018 to February 2020, assessing 1- and 12-month serial vessel responses after stent implantation using OCT and coronary angioscopy. Time-dependent change in the presence of IP was evaluated using the serial OCT examinations. The cumulative 3-year incidence of TLR was compared between the lesions with and without IP, as well as between those with and without residual IP at 1 month. Results: Among 107 lesions, IP was detected in post-OCT pullbacks in 38 (35.5%) lesions. Out of the 38 lesions, IP remained in 9 (23.7%) lesions at 1 month and existed in 2 (5.3%) lesions at 12 months. The cumulative 3-year incidence of TLR was significantly higher in IP group than in non-IP group (13.6% vs. 3.0%, p = 0.04). Similarly, it was significantly higher in lesions with residual IP at 1 month than those without (33.3% vs. 4.3%, p < 0.01). All residual IP at 1 month were composed of angioscopic yellow plaques and red thrombi. Conclusions: The presence of IP decreased over time, but approximately one-fourth of IP remained at 1 month. IP and residual IP at 1 month were important post-stent OCT findings leading to long-term TLR in patients with CCS.
Publisher	John Wiley and Sons Inc
Source Title	Catheterization and Cardiovascular Interventions
Date of Issued	2025-02-03
Language	English
Handle URL	https://hdl.handle.net/11094/100545
PISSN	15221946
eISSN	1522726X
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1002/ccd.31430
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

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Resource Type	journal article
Local Type	Journal Article
DCTERMS.bibliographicCitation	Catheterization and Cardiovascular Interventions. 2025
DC.title	Serial Change and Clinical Impact of Irregular Protrusion in Lesions With Chronic Coronary Syndrome
DC.creator	Okamoto, Naotaka
	Mizote, Isamu
	Ishihara, Takayuki
	Nakamura, Daisuke
	Shiraki, Tatsusya
	Itaya, Naoki
	Tsujimura, Takuya
	Takahara, Mitsuyoshi
	Hikosou, Shungo
	Mano, Toshiaki
	Ueno, Takahumi
	Nishino, Masami
	Nanto, Shinsuke
	Sakata, Yasushi
DC.publisher	John Wiley and Sons Inc
DC.language' scheme='DCTERMS.RFC1766	English
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-02-03
DC.identifier	https://doi.org/10.1002/ccd.31430
DC.subject	chronic coronary syndrome
	irregular protrusion
	optical coherence tomography
DC.description	Okamoto N., Mizote I., Ishihara T., et al. Serial Change and Clinical Impact of Irregular Protrusion in Lesions With Chronic Coronary Syndrome. Catheterization and Cardiovascular Interventions, (2025); https://doi.org/10.1002/ccd.31430.
DCTERMS.abstract	Background: The changes over time and effects on long-term clinical outcomes beyond 1 year of irregular protrusion (IP) in chronic coronary syndrome (CCS) remains unclear. Aims: This study aimed to assess the time-dependent change and long-term clinical impact of IP in CCS lesions. Methods: This study was a post hoc analysis of COLLABORATION study, which was a multicenter, prospective, observational study conducted from July 2018 to February 2020, assessing 1- and 12-month serial vessel responses after stent implantation using OCT and coronary angioscopy. Time-dependent change in the presence of IP was evaluated using the serial OCT examinations. The cumulative 3-year incidence of TLR was compared between the lesions with and without IP, as well as between those with and without residual IP at 1 month. Results: Among 107 lesions, IP was detected in post-OCT pullbacks in 38 (35.5%) lesions. Out of the 38 lesions, IP remained in 9 (23.7%) lesions at 1 month and existed in 2 (5.3%) lesions at 12 months. The cumulative 3-year incidence of TLR was significantly higher in IP group than in non-IP group (13.6% vs. 3.0%, p = 0.04). Similarly, it was significantly higher in lesions with residual IP at 1 month than those without (33.3% vs. 4.3%, p < 0.01). All residual IP at 1 month were composed of angioscopic yellow plaques and red thrombi. Conclusions: The presence of IP decreased over time, but approximately one-fourth of IP remained at 1 month. IP and residual IP at 1 month were important post-stent OCT findings leading to long-term TLR in patients with CCS.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
DC.format	100545
citation_title	Serial Change and Clinical Impact of Irregular Protrusion in Lesions With Chronic Coronary Syndrome
citation_author	Okamoto, Naotaka
	Mizote, Isamu
	Ishihara, Takayuki
	Nakamura, Daisuke
	Shiraki, Tatsusya
	Itaya, Naoki
	Tsujimura, Takuya
	Takahara, Mitsuyoshi
	Hikosou, Shungo
	Mano, Toshiaki
	Ueno, Takahumi
	Nishino, Masami
	Nanto, Shinsuke
	Sakata, Yasushi
citation_publisher	John Wiley and Sons Inc
citation_language	English
citation_date	2025-02-03
citation_journal_title	Catheterization and Cardiovascular Interventions
citation_doi	https://doi.org/10.1002/ccd.31430
citation_public_url	https://hdl.handle.net/11094/100545