A MULTICENTER, RANDOMIZED, OPEN-LABEL, PLACEBO-CONTROLLED CLINICAL TRIAL OF THE EFFECT OF CETYLPYRIDINIUM CHLORIDE (CPC) MOUTHWASH AND ON-DEMAND AQUEOUS CHLORINE DIOXIDE MOUTHWASH ON SARS-COV-2 VIRAL TITER IN PATIENTS WITH MILD COVID-19

ONOZUKA, DAISUKE; KONISHI, KEIJI; TAKATERA, SATOKO; OSAKI, MASAHIDE; SUMIYOSHI, SHOUGEN; TAKAHASHI, YUSUKE; HAMAGUCHI, SHIGETO; IMOTO, YASUO; KUTSUNA, SATOSHI

doi:https://doi.org/10.1016/j.jebdp.2024.102040

A MULTICENTER, RANDOMIZED, OPEN-LABEL, PLACEBO-CONTROLLED CLINICAL TRIAL OF THE EFFECT OF CETYLPYRIDINIUM CHLORIDE (CPC) MOUTHWASH AND ON-DEMAND AQUEOUS CHLORINE DIOXIDE MOUTHWASH ON SARS-COV-2 VIRAL TITER IN PATIENTS WITH MILD COVID-19

ONOZUKA, DAISUKE; KONISHI, KEIJI; TAKATERA, SATOKO et al.

Journal of Evidence-Based Dental Practice, 2024, 24(4), 102040

Number of Access:127（2025-06-07 13:17 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/100571

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Title	A MULTICENTER, RANDOMIZED, OPEN-LABEL, PLACEBO-CONTROLLED CLINICAL TRIAL OF THE EFFECT OF CETYLPYRIDINIUM CHLORIDE (CPC) MOUTHWASH AND ON-DEMAND AQUEOUS CHLORINE DIOXIDE MOUTHWASH ON SARS-COV-2 VIRAL TITER IN PATIENTS WITH MILD COVID-19
Creator	NRID 1000050446829 1000050446829 ORCID 0000-0001-9596-9188 0000-0001-9596-9188 researchmap permalink onozukad onozukad CreatorName ONOZUKA, DAISUKE
	CreatorName KONISHI, KEIJI
	CreatorName TAKATERA, SATOKO
	CreatorName OSAKI, MASAHIDE
	CreatorName SUMIYOSHI, SHOUGEN
	CreatorName TAKAHASHI, YUSUKE
	NRID 1000020735360 1000020735360 ORCID 0000-0003-2560-9982 0000-0003-2560-9982 researchmap permalink shama shama Scopus Author ID 55214104400 55214104400 CreatorName HAMAGUCHI, SHIGETO
	CreatorName IMOTO, YASUO
	researchmap permalink kutsunasatoshi kutsunasatoshi Scopus Author ID 55816237200 55816237200 CreatorName KUTSUNA, SATOSHI
Subject	Cetylpyridinium chloride
	COVID-19
	Epidemiology
	Mouthwash
	On-demand aqueous chlorine dioxide solution
	Randomized controlled trial
Description	ONOZUKA D., KONISHI K., TAKATERA S., et al. A MULTICENTER, RANDOMIZED, OPEN-LABEL, PLACEBO-CONTROLLED CLINICAL TRIAL OF THE EFFECT OF CETYLPYRIDINIUM CHLORIDE (CPC) MOUTHWASH AND ON-DEMAND AQUEOUS CHLORINE DIOXIDE MOUTHWASH ON SARS-COV-2 VIRAL TITER IN PATIENTS WITH MILD COVID-19. Journal of Evidence-Based Dental Practice 24, 102040 (2024); https://doi.org/10.1016/j.jebdp.2024.102040.
Abstract	Objectives: The established effect of cetylpyridinium chloride (CPC) mouthwash on SARS-CoV-2 viral titers is unclear. No clinical trial has examined the impact of on-demand aqueous chlorine dioxide mouthwash on SARS-CoV-2 viral titer. Methods: In this multicenter, 3-armed, randomized, open-label, placebo-controlled clinical trial involving mildly symptomatic COVID-19 patients, we randomly assigned them to receive 20 mL of 0.05% CPC, 10 mL of 0.01% on-demand aqueous chlorine dioxide, or 20 mL of purified water as a placebo mouthwash in a 1:1:1 ratio. The primary measurement was the SARS-CoV-2 viral titer in saliva, evaluated by a mixed-effects linear regression model. Results: 49 patients received CPC mouthwash (n=16), on-demand aqueous chlorine dioxide mouthwash (n=16), and placebo (n=17) between January 14, 2024, and February 20, 2024. 0.05% CPC mouthwash significantly reduced salivary viral titer at 10 minutes postuse (-0.97 log10 PFU/mL; 95% CI, -1.64 to -0.30; P =. 004), while no such effect was observed at 30 minutes (difference vs placebo, -0.26 log10 PFU/mL; 95% CI, -0.92 to 0.40; P =. 435) or 60 minutes (difference vs. placebo, -0.05 log10 PFU/mL; 95% CI, -0.68 to 0.58; P =. 877). 0.01% on-demand chlorine dioxide mouthwash did not reduce salivary viral titer at 10 minutes, 30 minutes, or 60 minutes compared to placebo. Conclusions: 10 minutes after using a 0.05% CPC mouthwash, the salivary viral titer of SARS-CoV-2 decreased compared to placebo. 0.01% on-demand aqueous chlorine dioxide mouthwash and placebo had no significant difference in SARS-CoV-2 viral titers.
Publisher	Elsevier Inc.
Source Title	Journal of Evidence-Based Dental Practice
Volume (Issue)	24(4)
Page	102040
Date of Issued	2024-12-01
Language	English
Handle URL	https://hdl.handle.net/11094/100571
PISSN	15323382
eISSN	15323390
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1016/j.jebdp.2024.102040
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCTERMS.bibliographicCitation	Journal of Evidence-Based Dental Practice. 2024, 24(4), p. 102040
DC.title	A MULTICENTER, RANDOMIZED, OPEN-LABEL, PLACEBO-CONTROLLED CLINICAL TRIAL OF THE EFFECT OF CETYLPYRIDINIUM CHLORIDE (CPC) MOUTHWASH AND ON-DEMAND AQUEOUS CHLORINE DIOXIDE MOUTHWASH ON SARS-COV-2 VIRAL TITER IN PATIENTS WITH MILD COVID-19
DC.creator	ONOZUKA, DAISUKE
	KONISHI, KEIJI
	TAKATERA, SATOKO
	OSAKI, MASAHIDE
	SUMIYOSHI, SHOUGEN
	TAKAHASHI, YUSUKE
	HAMAGUCHI, SHIGETO
	IMOTO, YASUO
	KUTSUNA, SATOSHI
DC.publisher	Elsevier Inc.
DC.language' scheme='DCTERMS.RFC1766	English
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-12-01
DC.identifier	https://doi.org/10.1016/j.jebdp.2024.102040
DC.subject	Cetylpyridinium chloride
	COVID-19
	Epidemiology
	Mouthwash
	On-demand aqueous chlorine dioxide solution
	Randomized controlled trial
DC.description	ONOZUKA D., KONISHI K., TAKATERA S., et al. A MULTICENTER, RANDOMIZED, OPEN-LABEL, PLACEBO-CONTROLLED CLINICAL TRIAL OF THE EFFECT OF CETYLPYRIDINIUM CHLORIDE (CPC) MOUTHWASH AND ON-DEMAND AQUEOUS CHLORINE DIOXIDE MOUTHWASH ON SARS-COV-2 VIRAL TITER IN PATIENTS WITH MILD COVID-19. Journal of Evidence-Based Dental Practice 24, 102040 (2024); https://doi.org/10.1016/j.jebdp.2024.102040.
DCTERMS.abstract	Objectives: The established effect of cetylpyridinium chloride (CPC) mouthwash on SARS-CoV-2 viral titers is unclear. No clinical trial has examined the impact of on-demand aqueous chlorine dioxide mouthwash on SARS-CoV-2 viral titer. Methods: In this multicenter, 3-armed, randomized, open-label, placebo-controlled clinical trial involving mildly symptomatic COVID-19 patients, we randomly assigned them to receive 20 mL of 0.05% CPC, 10 mL of 0.01% on-demand aqueous chlorine dioxide, or 20 mL of purified water as a placebo mouthwash in a 1:1:1 ratio. The primary measurement was the SARS-CoV-2 viral titer in saliva, evaluated by a mixed-effects linear regression model. Results: 49 patients received CPC mouthwash (n=16), on-demand aqueous chlorine dioxide mouthwash (n=16), and placebo (n=17) between January 14, 2024, and February 20, 2024. 0.05% CPC mouthwash significantly reduced salivary viral titer at 10 minutes postuse (-0.97 log10 PFU/mL; 95% CI, -1.64 to -0.30; P =. 004), while no such effect was observed at 30 minutes (difference vs placebo, -0.26 log10 PFU/mL; 95% CI, -0.92 to 0.40; P =. 435) or 60 minutes (difference vs. placebo, -0.05 log10 PFU/mL; 95% CI, -0.68 to 0.58; P =. 877). 0.01% on-demand chlorine dioxide mouthwash did not reduce salivary viral titer at 10 minutes, 30 minutes, or 60 minutes compared to placebo. Conclusions: 10 minutes after using a 0.05% CPC mouthwash, the salivary viral titer of SARS-CoV-2 decreased compared to placebo. 0.01% on-demand aqueous chlorine dioxide mouthwash and placebo had no significant difference in SARS-CoV-2 viral titers.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	100571
citation_title	A MULTICENTER, RANDOMIZED, OPEN-LABEL, PLACEBO-CONTROLLED CLINICAL TRIAL OF THE EFFECT OF CETYLPYRIDINIUM CHLORIDE (CPC) MOUTHWASH AND ON-DEMAND AQUEOUS CHLORINE DIOXIDE MOUTHWASH ON SARS-COV-2 VIRAL TITER IN PATIENTS WITH MILD COVID-19
citation_author	ONOZUKA, DAISUKE
	KONISHI, KEIJI
	TAKATERA, SATOKO
	OSAKI, MASAHIDE
	SUMIYOSHI, SHOUGEN
	TAKAHASHI, YUSUKE
	HAMAGUCHI, SHIGETO
	IMOTO, YASUO
	KUTSUNA, SATOSHI
citation_publisher	Elsevier Inc.
citation_language	English
citation_date	2024-12-01
citation_journal_title	Journal of Evidence-Based Dental Practice
citation_volume	24
citation_issue	4
citation_firstpage	102040
citation_doi	https://doi.org/10.1016/j.jebdp.2024.102040
citation_public_url	https://hdl.handle.net/11094/100571

A MULTICENTER, RANDOMIZED, OPEN-LABEL, PLACEBO-CONTROLLED CLINICAL TRIAL OF THE EFFECT OF CETYLPYRIDINIUM CHLORIDE (CPC) MOUTHWASH AND ON-DEMAND AQUEOUS CHLORINE DIOXIDE MOUTHWASH ON SARS-COV-2 VIRAL TITER IN PATIENTS WITH MILD COVID-19

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