Comparison of Vessel Responses Following Combined Sirolimus-Eluting and Endothelial Progenitor Cell Stent and Ultra-Thin Sirolimus-Eluting Stent Implantation by Serial Optical Coherence Tomography and Coronary Angioscopy: A Multicenter Observational Study

Nakamura, Daisuke; Mizote, Isamu; Ishihara, Takayuki; Matsuhiro, Yutaka; Okuno, Shota; Shiraki, Tatsuya; Tsujimura, Takuya; Okamoto, Naotaka; Itaya, Naoki; Nakayoshi, Takaharu; Kikuchi, Atsushi; Kawai, Tsutomu; Nojima, Yuhei; Takahara, Mitsuyoshi; Morita, Takashi; Hikosou, Shungo; Nakatani, Daisaku; Mano, Toshiaki; Yamada, Takahisa; Ueno, Takahumi; Nishino, Masami; Nanto, Shinsuke; Sakata, Yasushi

doi:https://doi.org/10.1016/j.amjcard.2025.01.009

Comparison of Vessel Responses Following Combined Sirolimus-Eluting and Endothelial Progenitor Cell Stent and Ultra-Thin Sirolimus-Eluting Stent Implantation by Serial Optical Coherence Tomography and Coronary Angioscopy: A Multicenter Observational Study

Nakamura, Daisuke; Mizote, Isamu; Ishihara, Takayuki et al.

American Journal of Cardiology, 2025, 241, 26-36

Number of Access:37（2025-04-30 13:14 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/100575

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Title	Comparison of Vessel Responses Following Combined Sirolimus-Eluting and Endothelial Progenitor Cell Stent and Ultra-Thin Sirolimus-Eluting Stent Implantation by Serial Optical Coherence Tomography and Coronary Angioscopy: A Multicenter Observational Study
Creator	NRID 1000030869970 1000030869970 researchmap permalink daifromn0525 daifromn0525 CreatorName Nakamura, Daisuke
	NRID 1000010584609 1000010584609 researchmap permalink mizoteisamu mizoteisamu Scopus Author ID 8266113500 8266113500 CreatorName Mizote, Isamu
	CreatorName Ishihara, Takayuki
	ORCID 0000-0002-5229-6857 0000-0002-5229-6857 CreatorName Matsuhiro, Yutaka
	researchmap permalink okunoshota okunoshota CreatorName Okuno, Shota
	NRID 1000060784056 1000060784056 CreatorName Shiraki, Tatsuya
	CreatorName Tsujimura, Takuya
	CreatorName Okamoto, Naotaka
	CreatorName Itaya, Naoki
	NRID 1000090511824 1000090511824 CreatorName Nakayoshi, Takaharu
	CreatorName Kikuchi, Atsushi
	CreatorName Kawai, Tsutomu
	CreatorName Nojima, Yuhei
	NRID 1000000751067 1000000751067 researchmap permalink takahara-mitsuyoshi takahara-mitsuyoshi Scopus Author ID 35933605700 35933605700 CreatorName Takahara, Mitsuyoshi
	CreatorName Morita, Takashi
	NRID 1000030423164 1000030423164 researchmap permalink hikoso_osakauniv hikoso_osakauniv CreatorName Hikosou, Shungo
	NRID 1000060444535 1000060444535 researchmap permalink dsyma dsyma Scopus Author ID 6603545219 6603545219 CreatorName Nakatani, Daisaku
	NRID 1000090379165 1000090379165 CreatorName Mano, Toshiaki
	NRID 1000040649844 1000040649844 CreatorName Yamada, Takahisa
	CreatorName Ueno, Takahumi
	CreatorName Nishino, Masami
	CreatorName Nanto, Shinsuke
	NRID 1000000397671 1000000397671 ORCID 0000-0002-5618-4721 0000-0002-5618-4721 researchmap permalink C4589 C4589 Scopus Author ID 35395964700 35395964700 CreatorName Sakata, Yasushi
Subject	Drug-eluting stent
	Multi vessel disease
	Optical coherence tomography
	Stable angina
Description	Nakamura D., Mizote I., Ishihara T., et al. Comparison of Vessel Responses Following Combined Sirolimus-Eluting and Endothelial Progenitor Cell Stent and Ultra-Thin Sirolimus-Eluting Stent Implantation by Serial Optical Coherence Tomography and Coronary Angioscopy: A Multicenter Observational Study. American Journal of Cardiology 241, 26 (2025); https://doi.org/10.1016/j.amjcard.2025.01.009.
Abstract	A dual-therapy sirolimus-eluting and CD34+ antibody–coated Combo Stent (DTS) has been developed to enhance endothelization and capture endothelial progenitor cells; however, vessel responses following DTS implantation remain unclear. Therefore, we evaluated early- and mid-term intravascular characteristics of DTS using intravascular imaging modalities. This multicenter, prospective, observational study enrolled 88 patients (95 lesions) who underwent DTS (43 patients, 48 lesions) or sirolimus-eluting Orsiro stent (SES, 45 patients, 47 lesions) implantation. Serial optical coherence tomography (OCT) and coronary angioscopy (CAS) findings were compared between the groups at 1 and 12 months.The OCT findings were similar between the DTS and SES groups at 1 month, including the covered strut rate (84.21 ± 9.50% versus 80.56 ± 17.68%, p = 0.27). CAS findings were also comparable despite a more severe yellow coloration observed in the DTS group (p = 0.006). At 12 months, OCT findings revealed that the covered and adequate strut coverage (≥40 μm) rates were significantly higher (99.27 ± 0.95% versus 95.46 ± 5.56%, p <0.001 and 88.90 ± 10.15% versus 72.96 ± 16.48%, p <0.001) and neointimal thickness was significantly thicker (152.16 ± 70.31 versus 84.39 ± 29.80 μm, p <0.001) in DTS than in SES. The malapposed strut rate was significantly higher in SES than in DTS (0.04 ± 0.18% versus 0.82 ± 1.87%, p = 0.018). CAS revealed that the yellow coloration (p = 0.049) and subclinical intrastent thrombus (p = 0.019) were less severe in DTS than in SES at 12 months. In conclusion, DTS provided better advantages regarding strut coverage and plaque stabilization compared to SES. However, given the observational nature of this study, further randomized controlled trials are needed to confirm these findings.
Publisher	Elsevier Inc.
Source Title	American Journal of Cardiology
Volume (Issue)	241
Page	26-36
Date of Issued	2025-04-15
Language	English
Handle URL	https://hdl.handle.net/11094/100575
PISSN	00029149
eISSN	18791913
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1016/j.amjcard.2025.01.009
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCTERMS.bibliographicCitation	American Journal of Cardiology. 2025, 241, p. 26-36
DC.title	Comparison of Vessel Responses Following Combined Sirolimus-Eluting and Endothelial Progenitor Cell Stent and Ultra-Thin Sirolimus-Eluting Stent Implantation by Serial Optical Coherence Tomography and Coronary Angioscopy: A Multicenter Observational Study
DC.creator	Nakamura, Daisuke
	Mizote, Isamu
	Ishihara, Takayuki
	Matsuhiro, Yutaka
	Okuno, Shota
	Shiraki, Tatsuya
	Tsujimura, Takuya
	Okamoto, Naotaka
	Itaya, Naoki
	Nakayoshi, Takaharu
	Kikuchi, Atsushi
	Kawai, Tsutomu
	Nojima, Yuhei
	Takahara, Mitsuyoshi
	Morita, Takashi
	Hikosou, Shungo
	Nakatani, Daisaku
	Mano, Toshiaki
	Yamada, Takahisa
	Ueno, Takahumi
	Nishino, Masami
	Nanto, Shinsuke
	Sakata, Yasushi
DC.publisher	Elsevier Inc.
DC.language' scheme='DCTERMS.RFC1766	English
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-04-15
DC.identifier	https://doi.org/10.1016/j.amjcard.2025.01.009
DC.subject	Drug-eluting stent
	Multi vessel disease
	Optical coherence tomography
	Stable angina
DC.description	Nakamura D., Mizote I., Ishihara T., et al. Comparison of Vessel Responses Following Combined Sirolimus-Eluting and Endothelial Progenitor Cell Stent and Ultra-Thin Sirolimus-Eluting Stent Implantation by Serial Optical Coherence Tomography and Coronary Angioscopy: A Multicenter Observational Study. American Journal of Cardiology 241, 26 (2025); https://doi.org/10.1016/j.amjcard.2025.01.009.
DCTERMS.abstract	A dual-therapy sirolimus-eluting and CD34+ antibody–coated Combo Stent (DTS) has been developed to enhance endothelization and capture endothelial progenitor cells; however, vessel responses following DTS implantation remain unclear. Therefore, we evaluated early- and mid-term intravascular characteristics of DTS using intravascular imaging modalities. This multicenter, prospective, observational study enrolled 88 patients (95 lesions) who underwent DTS (43 patients, 48 lesions) or sirolimus-eluting Orsiro stent (SES, 45 patients, 47 lesions) implantation. Serial optical coherence tomography (OCT) and coronary angioscopy (CAS) findings were compared between the groups at 1 and 12 months.The OCT findings were similar between the DTS and SES groups at 1 month, including the covered strut rate (84.21 ± 9.50% versus 80.56 ± 17.68%, p = 0.27). CAS findings were also comparable despite a more severe yellow coloration observed in the DTS group (p = 0.006). At 12 months, OCT findings revealed that the covered and adequate strut coverage (≥40 μm) rates were significantly higher (99.27 ± 0.95% versus 95.46 ± 5.56%, p <0.001 and 88.90 ± 10.15% versus 72.96 ± 16.48%, p <0.001) and neointimal thickness was significantly thicker (152.16 ± 70.31 versus 84.39 ± 29.80 μm, p <0.001) in DTS than in SES. The malapposed strut rate was significantly higher in SES than in DTS (0.04 ± 0.18% versus 0.82 ± 1.87%, p = 0.018). CAS revealed that the yellow coloration (p = 0.049) and subclinical intrastent thrombus (p = 0.019) were less severe in DTS than in SES at 12 months. In conclusion, DTS provided better advantages regarding strut coverage and plaque stabilization compared to SES. However, given the observational nature of this study, further randomized controlled trials are needed to confirm these findings.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
DC.format	100575
citation_title	Comparison of Vessel Responses Following Combined Sirolimus-Eluting and Endothelial Progenitor Cell Stent and Ultra-Thin Sirolimus-Eluting Stent Implantation by Serial Optical Coherence Tomography and Coronary Angioscopy: A Multicenter Observational Study
citation_author	Nakamura, Daisuke
	Mizote, Isamu
	Ishihara, Takayuki
	Matsuhiro, Yutaka
	Okuno, Shota
	Shiraki, Tatsuya
	Tsujimura, Takuya
	Okamoto, Naotaka
	Itaya, Naoki
	Nakayoshi, Takaharu
	Kikuchi, Atsushi
	Kawai, Tsutomu
	Nojima, Yuhei
	Takahara, Mitsuyoshi
	Morita, Takashi
	Hikosou, Shungo
	Nakatani, Daisaku
	Mano, Toshiaki
	Yamada, Takahisa
	Ueno, Takahumi
	Nishino, Masami
	Nanto, Shinsuke
	Sakata, Yasushi
citation_publisher	Elsevier Inc.
citation_language	English
citation_date	2025-04-15
citation_journal_title	American Journal of Cardiology
citation_volume	241
citation_firstpage	26
citation_lastpage	36
citation_doi	https://doi.org/10.1016/j.amjcard.2025.01.009
citation_public_url	https://hdl.handle.net/11094/100575

Comparison of Vessel Responses Following Combined Sirolimus-Eluting and Endothelial Progenitor Cell Stent and Ultra-Thin Sirolimus-Eluting Stent Implantation by Serial Optical Coherence Tomography and Coronary Angioscopy: A Multicenter Observational Study

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