Highly soluble and well-defined polysaccharide-based micelle in aqueous media: Decyl succinic anhydride-modified pullulan

Suenaga, Risa; Komuro, Yuzu; Terao, Ken

Carbohydrate Polymers, 2025, 358, 123504

Number of Access:117（2025-12-08 16:59 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/100612

Link to primary information 

File Format Terms of use Size Views Date.Available Description information
CarbohydratePolymers_358_123504 pdf None 6.77 MB 87 2025.03.24  
Creative Commons : Attribution

Item Information

Output File Export EndNote Basic Export Mendeley

Title
Highly soluble and well-defined polysaccharide-based micelle in aqueous media: Decyl succinic anhydride-modified pullulan
Creator
CreatorName
Suenaga, Risa
CreatorName
Komuro, Yuzu
NRID
1000060334132 1000060334132
ORCID
0000-0001-7363-4491 0000-0001-7363-4491
researchmap permalink
kenterao kenterao
Scopus Author ID
7101653015 7101653015
CreatorName
Terao, Ken
Subject
Amphiphilic polysaccharide derivative
Pullulan
Flower micelle
Small-angle X-ray scattering
Light scattering
Description
Suenaga Risa, Komuro Yuzu, Terao Ken. Highly soluble and well-defined polysaccharide-based micelle in aqueous media: Decyl succinic anhydride-modified pullulan. Carbohydrate Polymers 358, 123504 (2025); https://doi.org/10.1016/j.carbpol.2025.123504.
Abstract
A pullulan-based polymeric micelle was obtained by modifying pullulan with decyl succinic anhydride (PulDS) to achieve a degree of substitution ranging from 0.46 to 0.72. SEC-MALS, static and dynamic light scattering, small angle X-ray scattering (SAXS), and fluorescence measurements were performed to characterize the micelle structure of PulDS in 25 mM aqueous NaCl at two different pH of 7 and 10. The scattering and fluorescence data clearly showed that the PulDS is molecularly dispersed as flower necklace micelles in the aqueous solvents. The size distribution of the unit micelles is significantly narrower than that of the previously investigated succinic anhydride modified pullulan. The resulting unit micelle size was found to depend less on chain length and degree of substitution, but the unit flower micelle was larger at pH 7 than at pH 10, suggesting that excess ionized OH groups on the glycosidic ring provide repulsive forces between the polymer chains. These features, namely the well-defined micelle structure and high solubility in aqueous media without large aggregates, indicate potential applications in drug delivery systems and as food additives.
Publisher
Elsevier BV
Source Title
Carbohydrate Polymers
Volume (Issue)
358
Page
123504
Date of Issued
2025-06-15
Language
English
Handle URL
https://hdl.handle.net/11094/100612
PISSN
01448617
Relation.isIdenticalTo
DOI (Publisher Version)
https://doi.org/10.1016/j.carbpol.2025.123504
Access Rights
open access
CopyRight
This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version
Version of Record
Category
学術雑誌論文 Journal Article