Association of Aortic Root and Valve Morphology With De Novo Aortic Valve Regurgitation After Implantation of Left Ventricular Assist Device

Murakami, Takashi; Misumi, Yusuke; Yoshioka, Daisuke et al.

Artificial Organs, 2025

Number of Access:1,013（2025-07-22 20:36 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/100961

Link to primary information 

File Format Terms of use Size Views Date.Available Description information
ArtifOrgans pdf None 714 KB 21 2025.04.15  
Creative Commons : Attribution

Item Information

Output File Export EndNote Basic Export Mendeley

Title
Association of Aortic Root and Valve Morphology With De Novo Aortic Valve Regurgitation After Implantation of Left Ventricular Assist Device
Creator
CreatorName
Murakami, Takashi
NRID
1000020631477 1000020631477
researchmap permalink
yusukemisumi yusukemisumi
CreatorName
Misumi, Yusuke
CreatorName
Yoshioka, Daisuke
NRID
1000060839398 1000060839398
researchmap permalink
takuji-kawamura takuji-kawamura
Scopus Author ID
55331768500 55331768500
ORCID
0000-0003-2985-0036 0000-0003-2985-0036
CreatorName
Kawamura, Takuji
NRID
1000010838923 1000010838923
researchmap permalink
a-kawamura a-kawamura
Scopus Author ID
56414159900 56414159900
CreatorName
Kawamura, Ai
CreatorName
Yajima, Shin
CreatorName
Saito, Shunsuke
NRID
1000020527999 1000020527999
CreatorName
Yamauchi, Takashi
NRID
1000070544237 1000070544237
ORCID
0000-0003-0015-6569 0000-0003-0015-6569
researchmap permalink
s-miyagawa3154 s-miyagawa3154
Scopus Author ID
55560624700 55560624700
CreatorName
Miyagawa, Shigeru
Subject
aortic root morphology
continuous-flow left ventricular assist device
de novo aortic valve insufficiency
Description
Murakami T., Misumi Y., Yoshioka D., et al. Association of Aortic Root and Valve Morphology With De Novo Aortic Valve Regurgitation After Implantation of Left Ventricular Assist Device. Artificial Organs , (2025); https://doi.org/10.1111/aor.14987.
Abstract
Background: The development of aortic valve regurgitation (AR) negatively affects the survival of patients with continuous-flow left ventricular assist device (LVAD) support. Although several risk factors have been identified, little is known about the effect of preoperative aortic root and valve morphology on the development of de novo AR after LVAD implantation. Methods: Between April 2018 and September 2023, 87 patients underwent durable LVAD implantation at our department. Of these, the 15 eligible patients who underwent preoperative electrocardiography-synchronized cardiac contrast-enhanced computed tomography were included in this study. Baseline aortic root and valve morphology and its relationship with the postoperative development of AR were retrospectively reviewed. Results: The mean duration of LVAD support was 1208 ± 618 days. At 60 months postsurgery, 10 patients had mild or greater AR (Group I) and the others did not (Group N). The measurement of baseline aortic root morphology showed that the ratio of virtual basal ring diameter to geometric height (VBD/GH) was significantly larger for Group I (1.70 ± 0.024 vs. 1.48 ± 0.034; p = 0.0001). Conclusions: A large preoperative VBD/GH is a significant risk factor for de novo AR. This finding may assist in determining the surgical indications for concomitant aortic valve procedures with durable LVAD implantation.
Publisher
John Wiley and Sons Inc
Source Title
Artificial Organs
Date of Issued
2025-03-12
Language
English
Handle URL
https://hdl.handle.net/11094/100961
PISSN
0160564X
eISSN
15251594
Relation.isIdenticalTo
DOI (Publisher Version)
https://doi.org/10.1111/aor.14987
Access Rights
open access
CopyRight
This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version
Version of Record
Category
学術雑誌論文 Journal Article