d-Alanine, a Circadian Metabolite that Regulates Glucose Metabolism and Viral Infection

Kimura, Tomonori; Sakai, Shinsuke; Isaka, Yoshitaka

ChemBioChem, 2025, e202500018

Number of Access:469（2025-09-12 06:38 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/100962

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Title
d-Alanine, a Circadian Metabolite that Regulates Glucose Metabolism and Viral Infection
Creator
NRID
1000000631300 1000000631300
ORCID
0000-0001-8186-094X 0000-0001-8186-094X
researchmap permalink
KimuraUNM KimuraUNM
Scopus Author ID
57199363473 57199363473
CreatorName
Kimura, Tomonori
NRID
1000060817360 1000060817360
CreatorName
Sakai, Shinsuke
NRID
1000000379166 1000000379166
researchmap permalink
isaka-handai3857 isaka-handai3857
Scopus Author ID
16207611100 16207611100
ORCID
0000-0002-0820-7167 0000-0002-0820-7167
CreatorName
Isaka, Yoshitaka
Subject
Circadian rhythm
d-Alanine
d-Amino acids
Glucose metabolism
Viral infection
Description
Kimura T., Sakai S., Isaka Y.. d-Alanine, a Circadian Metabolite that Regulates Glucose Metabolism and Viral Infection. ChemBioChem , (2025); https://doi.org/10.1002/cbic.202500018.
Abstract
d-Alanine, a rare d-amino acid, exhibits a clear circadian rhythm and is present in organs associated with glucose metabolism. Recent findings have revealed that d-alanine acts on the circadian rhythm, thereby regulating physiological processes related to circadian cycles that are essential for maintaining body homeostasis. The regulation of circadian rhythm by d-alanine is vital for correcting blood glucose levels in diabetic conditions. In viral infections, d-alanine serves as a sensitive biomarker that reflects the severity of the infection, as its level drastically decreases due to consumption. Supplementation with d-alanine is effective to alleviate the progression of viral infections, potentially through the maintenance of the circadian rhythm and its associated immune responses. In addition to its role as a circadian biomarker, d-alanine also functions as a circadian regulator and exerts a wide range of physiological effects. This review summarizes the physiological roles of d-alanine as a circadian metabolite.
Publisher
John Wiley and Sons Inc
Source Title
ChemBioChem
Page
e202500018
Date of Issued
2025-02-18
Language
English
Handle URL
https://hdl.handle.net/11094/100962
PISSN
14394227
eISSN
14397633
Relation.isIdenticalTo
DOI (Publisher Version)
https://doi.org/10.1002/cbic.202500018
Access Rights
open access
CopyRight
This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
oaire:version
Version of Record
Category
学術雑誌論文 Journal Article