Comparing the osteogenic effects of sputtered titanium- and strontium titanate (STO)-modified polyetheretherketone

Ikuta, Masato; Harumningtyas, Anjar Anggraini; Ito, Tomoko; Fujita, Kenta; Kitahara, Takayuki; Bun, Masayuki; Furuichi, Takuya; Hirai, Hiromasa; Ukon, Yuichiro; Tateiwa, Daisuke; Kanie, Yuya; Furuya, Masayuki; Fujimori, Takahito; Okada, Seiji; Hamaguchi, Satoshi; Kaito, Takashi

doi:https://doi.org/10.1007/s42247-025-01033-8

Comparing the osteogenic effects of sputtered titanium- and strontium titanate (STO)-modified polyetheretherketone

Ikuta, Masato; Harumningtyas, Anjar Anggraini; Ito, Tomoko et al.

Emergent Materials, 2025

Number of Access:1,733（2025-07-24 02:21 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/101002

Link to primary information

File	Format	Terms of use	Size	Views	Date.Available	Description	information
EmergMater	pdf	None	2.79 MB	21	2025.04.17

Creative Commons : Attribution

Item Information

Output File Export EndNote Basic Export Mendeley

Title	Comparing the osteogenic effects of sputtered titanium- and strontium titanate (STO)-modified polyetheretherketone
Creator	CreatorName Ikuta, Masato
	CreatorName Harumningtyas, Anjar Anggraini
	NRID 1000010724784 1000010724784 researchmap permalink plasma0326 plasma0326 CreatorName Ito, Tomoko
	CreatorName Fujita, Kenta
	CreatorName Kitahara, Takayuki
	CreatorName Bun, Masayuki
	CreatorName Furuichi, Takuya
	CreatorName Hirai, Hiromasa
	NRID 1000050964334 1000050964334 ORCID 0000-0002-0747-8854 0000-0002-0747-8854 researchmap permalink yuichiro.ukon yuichiro.ukon CreatorName Ukon, Yuichiro
	CreatorName Tateiwa, Daisuke
	NRID 1000010896377 1000010896377 researchmap permalink ykanie1985 ykanie1985 CreatorName Kanie, Yuya
	NRID 1000020987466 1000020987466 researchmap permalink furuya1019 furuya1019 CreatorName Furuya, Masayuki
	NRID 1000080546888 1000080546888 researchmap permalink fujimori_takahito fujimori_takahito Scopus Author ID 35271904600 35271904600 CreatorName Fujimori, Takahito
	NRID 1000030448435 1000030448435 ORCID 0000-0002-5107-8209 0000-0002-5107-8209 researchmap permalink okadaseiji okadaseiji Scopus Author ID 35079139100 35079139100 CreatorName Okada, Seiji
	NRID 1000060301826 1000060301826 ORCID 0000-0001-6580-8797 0000-0001-6580-8797 researchmap permalink satoshi_hamaguchi satoshi_hamaguchi Scopus Author ID 55220082400 55220082400 CreatorName Hamaguchi, Satoshi
	NRID 1000070623982 1000070623982 ORCID 0000-0003-4882-2997 0000-0003-4882-2997 researchmap permalink 911_0 911_0 Scopus Author ID 25824322100 25824322100 CreatorName Kaito, Takashi
Subject	Magnetron sputtering
	Osseointegration
	Polyetheretherketone
	Strontium titanate
	Surface modification
Description	The version of record of this article, first published in Emergent Materials, is available online at Publisher’s website: https://doi.org/10.1007/s42247-025-01033-8
Abstract	Polyetheretherketone (PEEK) is widely used as an interbody cage due to its elastic modulus closely resembles that of human bone. However, its biological inertness is considered a major weakness, as it cannot directly bond with bone (lack of osseointegration capacity). Surface modification can impart bioactivity to PEEK while maintaining its mechanical properties. In this study, the surface of PEEK was modified with titanium or strontium titanate thin films formed by magnetron sputtering deposition. We evaluated the bone formation activity of strontium titanate-modified PEEK (PEEK-STO) by comparing three groups: unmodified PEEK (PEEK), titanium-modified PEEK (PEEK-Ti), and strontium titanate-modified PEEK (PEEK-STO). Osteogenic differentiation of cells, assessed by ALP activity, bone-related gene expression, and mineralization ability, demonstrated that PEEK-STO has the highest osteogenic activity. Furthermore, the evaluation of mineral deposition by non-cellular mechanisms using simulated body fluid showed that PEEK-Ti and PEEK-STO have higher calcium phosphate deposition capacity than PEEK. In vivo implantation of the materials into the rat femur demonstrated that bone-to-implant contact ratio (BIC%) and bone area ratio (BA%) in the proximity zone from the implant were significantly larger in PEEK-STO compared to PEEK-Ti and PEEK at 4 weeks post-surgery. This study demonstrates that surface modification of PEEK with strontium titanate through magnetron sputtering is an attractive option for solving the problems of PEEK’s biological inertness while making the most of the advantages of PEEK as a spinal fusion device.
Publisher	Springer Nature
Source Title	Emergent Materials
Date of Issued	2025-02-25
Language	English
Handle URL	https://hdl.handle.net/11094/101002
PISSN	25225731
eISSN	2522574X
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1007/s42247-025-01033-8
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCTERMS.bibliographicCitation	Emergent Materials. 2025
DC.title	Comparing the osteogenic effects of sputtered titanium- and strontium titanate (STO)-modified polyetheretherketone
DC.creator	Ikuta, Masato
	Harumningtyas, Anjar Anggraini
	Ito, Tomoko
	Fujita, Kenta
	Kitahara, Takayuki
	Bun, Masayuki
	Furuichi, Takuya
	Hirai, Hiromasa
	Ukon, Yuichiro
	Tateiwa, Daisuke
	Kanie, Yuya
	Furuya, Masayuki
	Fujimori, Takahito
	Okada, Seiji
	Hamaguchi, Satoshi
	Kaito, Takashi
DC.publisher	Springer Nature
DC.language' scheme='DCTERMS.RFC1766	English
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-02-25
DC.identifier	https://doi.org/10.1007/s42247-025-01033-8
DC.subject	Magnetron sputtering
	Osseointegration
	Polyetheretherketone
	Strontium titanate
	Surface modification
DC.description	The version of record of this article, first published in Emergent Materials, is available online at Publisher’s website: https://doi.org/10.1007/s42247-025-01033-8
DCTERMS.abstract	Polyetheretherketone (PEEK) is widely used as an interbody cage due to its elastic modulus closely resembles that of human bone. However, its biological inertness is considered a major weakness, as it cannot directly bond with bone (lack of osseointegration capacity). Surface modification can impart bioactivity to PEEK while maintaining its mechanical properties. In this study, the surface of PEEK was modified with titanium or strontium titanate thin films formed by magnetron sputtering deposition. We evaluated the bone formation activity of strontium titanate-modified PEEK (PEEK-STO) by comparing three groups: unmodified PEEK (PEEK), titanium-modified PEEK (PEEK-Ti), and strontium titanate-modified PEEK (PEEK-STO). Osteogenic differentiation of cells, assessed by ALP activity, bone-related gene expression, and mineralization ability, demonstrated that PEEK-STO has the highest osteogenic activity. Furthermore, the evaluation of mineral deposition by non-cellular mechanisms using simulated body fluid showed that PEEK-Ti and PEEK-STO have higher calcium phosphate deposition capacity than PEEK. In vivo implantation of the materials into the rat femur demonstrated that bone-to-implant contact ratio (BIC%) and bone area ratio (BA%) in the proximity zone from the implant were significantly larger in PEEK-STO compared to PEEK-Ti and PEEK at 4 weeks post-surgery. This study demonstrates that surface modification of PEEK with strontium titanate through magnetron sputtering is an attractive option for solving the problems of PEEK’s biological inertness while making the most of the advantages of PEEK as a spinal fusion device.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	101002
citation_title	Comparing the osteogenic effects of sputtered titanium- and strontium titanate (STO)-modified polyetheretherketone
citation_author	Ikuta, Masato
	Harumningtyas, Anjar Anggraini
	Ito, Tomoko
	Fujita, Kenta
	Kitahara, Takayuki
	Bun, Masayuki
	Furuichi, Takuya
	Hirai, Hiromasa
	Ukon, Yuichiro
	Tateiwa, Daisuke
	Kanie, Yuya
	Furuya, Masayuki
	Fujimori, Takahito
	Okada, Seiji
	Hamaguchi, Satoshi
	Kaito, Takashi
citation_publisher	Springer Nature
citation_language	English
citation_date	2025-02-25
citation_journal_title	Emergent Materials
citation_doi	https://doi.org/10.1007/s42247-025-01033-8
citation_public_url	https://hdl.handle.net/11094/101002

Comparing the osteogenic effects of sputtered titanium- and strontium titanate (STO)-modified polyetheretherketone

Link to primary information

Item Information

Show details